Whack-a-Mole: Testing an Intervention to Increase Melanoma Identification
Diagnoses DiseaseThe purpose of this study is to evaluate an interactive game designed to increase people's ability to identify cancerous moles.
Suction Drain in Axillary Lymph Node Dissection for Malignant Melanoma
Malignant MelanomaPostoperative complications like seroma formation and wound site infection readily occur following completion axillary lymph node dissection (ALND) for malignant melanoma. We analyzed the impact of time-to-drain removal and drainage volume on seroma formation after ALND.
Exploring Unmet Needs and Attitudes to Skin Self-examination in Melanoma Survivors
MelanomaStage I3 moreThis is a prospective, multi-centred cohort study whereby the EUNASS Study questionnaire will be administered electronically to identify needs of melanoma survivors, the extent to which these needs are being met, and identify areas which have the greatest need for development. It will also evaluate behaviour in relation to sun protection and skin self-examination (SSE). It will be a self-completed questionnaire. Qualitative work using semi-structured interviews will explore the needs of melanoma survivors in greater depth, will present examples of potential interventions to improve SSE and explore factors that determine the likelihood of engaging in an intervention which can address unmet needs, such as improving SSE. Taken together, the data will provide the evidence base to inform the development of an intervention to improve SSE, which can subsequently be tested in secondary care services.
Ipilimumab-induced Lung Toxicity: Observational Study
Metastatic MelanomaSerial spirometries and measurements of CO-diffusion capacity (DLCO) in patients with MM before and during treatment with ipilimumab are performed. A reduction from baseline of forced vital capacity (FVC) of ≥10%, or ≥15% of DLCO was defined clinically meaningful, thus indicative for pulmonary toxicity.
Circulating Tumor Material in Colorectal Cancer and Melanoma
Colorectal Cancer and MelanomaObservational study to allow the collection of blood and medical information to evaluate the role of circulating tumor material in patients with colorectal cancer and melanoma
Expanded Access Study of Talimogene Laherparepvec for Treatment of Subjects With Unresected Stage...
Unresected Stage IIIB to IVM1c MelanomaThe study is a phase 3b, multicenter, open-label, single-arm study designed to provide expanded access of Talimogene Laherparepvec for the treatment of subjects with unresected stage IIIB to IVM1c melanoma. The study will also evaluate the safety and tolerability of Talimogene Laherparepvec.
Feasibility Study of Genomic Profiling Methods and Timing in Tumor Samples
Colorectal CancerBreast Cancer4 moreThis is a feasibility study to look for genetic alterations in tissue and blood samples that may be useful in determining what treatments may be useful in the patient's cancer care.
Clinical and Histopathologic Characteristics of BAP1 Mutations
Malignant Pleural Mesothelioma (MPM)Choroidal Nevus4 moreThe goal of this protocol is to determine the prevalence of somatic and germline mutations in BAP1 (BRCA associated protein-1) among patients with mesothelioma , choroidal nevus, primary uveal melanoma (UM), or metastatic UM seen at our institution.
A Translational Systems Medicine Approach to Provide Predictive Capacity for Therapy Response in...
Advanced MelanomaMetastatic MelanomaThis is an exploratory prospective translational multicentre study. Melanoma is the 5th most common cancer diagnosed in Ireland and its incidence among women and men is above the European average. Following treatment the elimination of cancer cells ultimately occurs by the activation of apoptotic cell death pathways. The SYS-ACT approach builds on a combination of mathematical systems of modelling, quantitative biochemistry and cell biology, and specifically predicts the drug responsiveness of melanoma cell lines to various apoptosis-inducing treatments. The investigators propose to validate the SYS-ACT approach and application in a translational systems medicine study.
Vascular Response to Brachytherapy Using Functional OCT
Uveal MelanomaThe purpose of this study is to learn how blood flows to tumors in patients treated with I-125 plaque brachytherapy for uveal melanoma.