search

Active clinical trials for "Acidosis"

Results 111-120 of 172

Phase 2c Dose Comparison Study of MP4OX in Trauma

TraumaHemorrhagic Shock1 more

MP4OX is being developed as an ischemic rescue therapy to perfuse and oxygenate tissues at risk during hemorrhagic shock. MP4OX is a pegylated hemoglobin-based colloid designed to improve perfusion and target delivery of oxygen to ischemic tissues. This study will evaluate safety and efficacy of MP4OX treatment, in addition to standard therapy, in trauma patients suffering from lactic acidosis due to severe hemorrhagic shock.

Withdrawn14 enrollment criteria

Anti-IL-1 Treatment in Children Diabetic Keto-Acidosis (DKA) at Diagnosis of Type 1 Diabetes

Type I Diabetes

This is a randomized, double-blind, placebo-controlled phase 2 study. Specific aim is to evaluate feasibility and safety of anti-IL-1 (interleukin 1) treatment in the course of standard therapy for diabetic ketoacidosis in children and its effect on intracranial pressure.

Withdrawn27 enrollment criteria

Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast...

Diabetes MellitusLactic Acidosis

The purpose of this study is to determine whether metformin causes lactic acidosis in diabetic patients with preserved kidney function, undergoing coronary angiography or angioplasty with new contrast media. In other words is it necessary to discontinue metformin before these procedures, even when Iodixanol is used as contrast media, which is isosmolar agent and much more safer than urografin which was the main agent in the previous studies that were the base of present guidelines?

Completed8 enrollment criteria

Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate

Urea Cycle DisordersInborn4 more

Hyperammonemia, which can cause brain damage, occurs in many different kinds of inborn errors of metabolism. The investigators propose to determine if short-term (3 day) treatment with N-carbamylglutamate can diminish hyperammonemia by enhancing ureagenesis in these patients. The investigators propose here a short-term (3 day) trial. If it succeeds, the investigators would consider more extensive long-term studies of the drug.

Withdrawn11 enrollment criteria

The Effect of the Cognitive Orientation to Daily Occupational Performance Approach for Children...

Organic AcidemiaCognitive Orientation

The aim of this study is to research the effect of Cognitive Orientation to daily Occupational Performance (the CO-OP Approach) on daily life activities, quality of life and participation in children with organic acidemia. The hypotheses of the study are as follows: Cognitive Orientation to daily Occupational Performance (the CO-OP Approach) applied to children with organic acidemia has no effect on daily life activities. Cognitive Orientation to daily Occupational Performance (the CO-OP Approach) applied to children with organic acidemia has no effect on quality of life. Cognitive Orientation to daily Occupational Performance (the CO-OP Approach) applied to children with organic acidemia has no effect on participation.

Completed7 enrollment criteria

Effect of Propofol and Sevoflurane on Lactate During Anesthesia for Pediatric Heart Catheterisation...

Metabolic Acidosis

Propofol is routinely used for general anesthesia during pediatric heart catheterisation. Propofol infusion syndrome (PRIS) is a rare, but often fatal complication mainly defined by bradycardia with progress to asystolia during propofol infusion. Metabolic acidosis is regarded as an early warning sign of PRIS. In this study the effect of propofol and sevoflurane on serum base excess, pH and lactate are examined during pediatric heart catheterisation.

Completed4 enrollment criteria

Prevention of Dichloroacetate Toxicity

AcidosisLactic1 more

This is a study to determine the safety of dichloroacetate (DCA) with a low-tyrosine diet given with or without nitisinone (NTBC) in children with chronic lactic acidosis (CLA).

Completed14 enrollment criteria

Risk Factors and Outcomes of Acute Kidney Injury in Patients With Diabetic Ketoacidosis at Sohag...

Diabetic KetoacidosisAcute Kidney Injury

Diabetic ketoacidosis (DKA), a severe complication of diabetes mellitus (DM), is the leading cause of hospitalization, morbidity and mortality in patients with DM (1). DKA is associated with hyperglycemic crises and featured by metabolic acidosis, the production of ketoacids, volume depletion, and electrolyte imbalance. Due to glucose-induced osmotic polyuria and even emesis, volume depletion is a major cause of acute kidney injury (AKI) in DKA patients (2).

Not yet recruiting2 enrollment criteria

High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement...

Metabolic AcidosisAcute Kidney Injury1 more

Researchers are trying to determine which dialysis solution, low bicarbonate fluid (22 mmol/L) or high bicarbonate fluid (32 mmol/L), is better in subjects with acute kidney injury (acute kidney failure) and metabolic acidosis that are admitted to the intensive care unit and require continuous renal replacement therapy (also known as continuous dialysis).

Withdrawn15 enrollment criteria

Management in Intensive Care Unit of Life-threatening Keto-Acidosis

Ketoacidosis

Patients hospitalized in intensive care between January 2014 and September 2021 for ketoacidosis complicated by organ failure in participating departments.

Not yet recruiting11 enrollment criteria
1...111213...18

Need Help? Contact our team!


We'll reach out to this number within 24 hrs