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Active clinical trials for "Acidosis"

Results 141-150 of 172

Lactic Acidosis During and After Seizures

Epilepsy

This project looks at the time course of lactic acid rise (if any) after seizures. Salivary and capillary lactic acid are tested. This type of measurement may be useful in signalling the occurrence or recent history of a seizure.

Completed10 enrollment criteria

Correction of Metabolic Acidosis in End Stage Renal Disease (ESRD)

Metabolic Acidosis

The investigators want to evaluate whether an original action based on the administration of alkali (mainly sodium bicarbonate) is able to significantly modify renal death and to reduce mortality due to cardiovascular events. Methods: This is a proposal of Multicentric, prospective, cohort, randomized, open-label and controlled study. The investigators will Randomize 728 patients with Chronic Kidney Disease(CKD) stage 3b (CKD-3b) and CKD stage 4: 364 of these patients will be included in the study group called Bicarbonate Group (Bic), in which levels of bicarbonate should be kept > 24 mEq/l; the other 364 patients will included in the Usual Treatment Group (no-Bic). Results: The aim of the Research Protocol is to demonstrate if that the optimal correction of uremic acidosis (with administration of sodium bicarbonate or of any other alkalinizing agent, e.g. sodium citrate) reduces renal and cardiovascular mortality. Conclusions. In conclusion the Work Group of the Conservative Therapy for Chronic Renal Insufficiency proposes this cohort, randomized, controlled, prospective, multicentric study to evaluate the effects of correction of acidosis on the progression of the kidney disease considered as renal death in End-Stage Renal Disease (ESRD) patients.

Unknown status10 enrollment criteria

Risk Potential for Organ Dysfunction Associated With Sodium Bicarbonate Therapy (SBT) in Critically...

Metabolic Acidosis; Critically Ill Patients; Organ Dysfunction

This study aimed to investigate whether hemodynamic status before SBT contributed to the effect of sodium bicarbonate infusion on the risk of neonatal organ dysfunction and mortality in critically ill patients with early metabolic acidosis in ICU.

Completed2 enrollment criteria

Perioperative Fluid Management in Patients Receiving Cadaveric Renal Transplants

Hyperkalaemia Requiring Postoperative DialysisMetabolic Acidosis

In this study we want to show that the choice of a balanced type fluid solution for the perioperative fluid management of patients receiving cadaveric renal transplantation results in less occurrence of intra- and postoperative hyperkalemia, and thus the need for postoperative dialysis. Additionally, we aim to determine whether the use of a balanced infusion solution leads to less occurrence of metabolic acidosis and electrolyte disorders than the use of isotonic saline. Furthermore we want to evaluate whether perioperative fluid management with balanced infusion solutions results in a higher frequency of primary graft function than with administration of isotonic saline. We will test the hypothesis that the use of "Elomel isoton"(Fresenius Kabi Austria GmbH) a balanced infusion solution will result in less occurrence of hyperkalemia and consequent post-transplant dialysis, less occurrence of metabolic acidosis, decreased incidence of electrolyte disorders and higher incidence of primary graft function when compared to isotonic saline for perioperative fluid management in patients receiving cadaveric renal transplantation.

Completed3 enrollment criteria

Substitution of Propofol by Sevoflurane During Pediatric Cardiopulmonary Bypass

Metabolic Acidosis

Propofol has been routinely used for general anesthesia during pediatric cardiopulmonary bypass at our institution without complications. However, propofol may cause propofol infusion syndrome (PRIS), a rare, but often fatal complication mainly defined by bradycardia with progress to asystolia. Metabolic acidosis is regarded as an early warning sign of PRIS. Due to the preconditioning effects of sevoflurane and its availability for cardiopulmonary bypass, propofol has recently been substituted by sevoflurane during pediatric cardiopulmonary bypass at our institution. In this study the effect of substituting propofol by sevoflurane on metabolic acidosis and outcome are examined.

Completed1 enrollment criteria

Evaluation of Respiratory Function in Fibromyalgia

FibromyalgiaRespiratory Alkalosis and Metabolic Acidosis1 more

This study will evaluate respiratory function in people with fibromyalgia and whether or not breathing patterns in this patient group can be explained by stress, emotional or biomechanical variables. In addition, examine the relationship between physical ability and lactate values.

Completed9 enrollment criteria

Pharmacotoxicology of Trichloroethylene Metabolites

Congenital Lactic Acidosis

To establish the relationship between human MAAI haplotype and DCA and tyrosine metabolism. This aim test the postulates that MAAI haplotype determines, and thus can predict,1) dose-dependent DCA kinetics and biotransformation.

Completed5 enrollment criteria

A Study Of Mircera In Patients With Kidney Disease Who Are Not On Dialysis

Renal Tubular AcidosisDistal1 more

This open-label, non-randomized, retrospective-prospective, non-interventional study will evaluate the efficacy and safety of Mircera in patients with stage III-IV chronic kidney disease (CKD) not on dialysis. Patients will receive open-label treatment with Mircera for 12 months at a dose to be determined by the investigator.

Completed10 enrollment criteria

Renal Tubular Acidosis is Highly Prevalent in Critically Ill Patients

AcidosisRenal Tubular

The aim of this study was to investigate the prevalence, type, and possible risk factors of RTA in critically ill patients using a physical-chemical approach.

Completed5 enrollment criteria

Autologous Stem Cells in Newborns With Oxygen Deprivation

Apgar; 0-3 at 1 MinuteMetabolic Acidosis3 more

The purpose of this study is to determine whether the plasticity of autologous intravenous application of cord blood stem cells would improve the clinical course of asphyxiated newborns.

Unknown status7 enrollment criteria
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