SENSOR: Study to Investigate Cinacalcet Treatment in Haemodialysis Patients With Secondary Hyperparathyroidism...
Secondary HyperparathyroidismEnd Stage Renal DiseaseThe purpose of this study is to demonstrate that the efficacy of cinacalcet when co-administered with the first meal after dialysis is comparable (non-inferior) to the efficacy of cinacalcet when administered during the dialysis study visit.
Cetuximab in Neoadjuvant Treatment of Non-Resectable Colorectal Liver Metastases (CELIM)
Colorectal CancerLiver MetastasesGeneral Objectives: To test the feasibility of neoadjuvant treatment with cetuximab/chemotherapy followed by liver resection To determine the optimal combination (cetuximab/FOLFOX versus cetuximab/FOLFIRI) for further trials in preoperative chemotherapy
Tarceva and Capecitabine for Pancreatic Cancer
Pancreatic CancerNeoplasm MetastasisThis phase II trial is designed to investigate the effectiveness of Tarceva (OSI-774) combined with capecitabine in treating patients with metastatic pancreatic cancer.
Brain Metastases Study: Radiotherapy Fractionation Schemes in the Treatment of Brain Metastases...
Neoplasm MetastasisBrain NeoplasmsThis is a comparison of radiotherapy fractionation schemes for brain metastasis.
Radioactive Holmium Microspheres for the Treatment of Liver Metastases
Liver MetastasisLiver TumorsThe HEPAR study is aimed at determining the safety of radioactive holmium containing microspheres for the treatment of tumors in the liver. These microspheres will be administered by infusion in the liver artery using a arterial catheter in the femoral artery.
Study of Fractionated Stereotactic Radiosurgery to Treat Large Brain Metastases
Brain CancerNeoplasm Metastasis2 moreThe maximum tolerated dose of 3-session (ie, treatment) stereotactic radiosurgery (SRS) to treat brain metastases greater than 4.2 cm³ in size will be determined. This study investigates if increasing radiation dose improves outcome for patients without greater toxicity (side effects).
Drug-Eluting Bead, Irinotecan (DEBIRI) Therapy of Liver Metastasis From Colon Cancer With Systemic...
Colon Cancer With Metastases to the LiverThis is a multicentre, open labeled, controlled phase study designed to assess effectiveness of chemoembolization with LC Beads, both with and without systemic chemotherapy, in the treatment of unresectable liver metastases in patients with colorectal cancer.
A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel Group Trial to Investigate...
Partial Seizures With or Without Secondary GeneralizationMale and female patients between 16 and 70 years of age who are diagnosed with epilepsy with partial seizures and are taking up to 3 medications for this medical condition will take part in this research study at approximately 80 different locations in Australia and Europe. The purpose of this study is to evaluate the effectiveness, safety and tolerability of consistent dosages of study drug (lacosamide) taken orally twice a day for about 4 months. Each patient who qualifies and chooses to participate in the study will receive placebo (inactive drug) or gradually increasing doses of lacosamide (SPM 927) up to the target dose of 200mg/day or 400mg/day. The target dose or placebo will be maintained for 12 weeks. The study clinic visits will include a medical history and physical exam, ECG, blood and urine sample collection, and completion of a seizure diary. Patients who complete the study may enroll in an extension trial and receive active study drug.
Study of Patupilone in Patients With Brain Metastasis From Non-small Cell Lung Cancer
Brain MetastasisNon-small Cell Lung CancerThe study objective is to evaluate the safety and efficacy of patupilone with respect to early progression and response of patients with non-small cell lung cancer (NSCLC) metastatic to the brain, who have progressed after chemotherapy, surgery and/or radiation.
Treatment of Unresectable Colorectal Metastases by Radiofrequency Ablation Combined or Not With...
Colorectal CancerThe hypothesis is that radiofrequency ablation combined or not with resection may allow a local control (the liver) in patients suffering from unresectable colorectal liver metastases. Patients may have benefit or not from a preoperative (neoadjuvant) chemotherapy.