Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic...
Accelerated Phase Chronic Myelogenous LeukemiaAcute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome53 moreThis study will determine the safety and applicability of experimental forms of umbilical cord blood (UCB) transplantation for patients with high risk hematologic malignancies who might benefit from a hematopoietic stem cell transplant (HSCT) but who do not have a standard donor option (no available HLA-matched related donor (MRD), HLA-matched unrelated donor (MUD)), or single UCB unit with adequate cell number and HLA-match).
18F-NaF PET Imaging for Bone Scintigraphy
Bone Metastases From Breast or Prostate CancerThe purpose of this study is to compare, in patients with prostate or breast cancer, the accuracy of 18F-NaF PET imaging to 99mTc whole body bone scans with single-photon emission computed tomography (SPECT).
Combo of Abraxane, TMZ, Bevacizumab in Metastatic Melanoma With Brain Metastases
Metastatic MelanomaBrain Metastases1.1. Primary Objectives 1. To determine if nab-paclitaxel and temozolomide can be combined with full dose of bevacizumab for the therapy of patients with newly diagnosed brain metastases of metastatic malignant melanoma. To define the MTD of the combination (Phase I component). To determine progression free survival (Phase II component). 1.2. Secondary Objectives To separately evaluate the response rate and duration of both the brain and extra-cranial systemic metastases. To define the toxicity of the regimen. To tabulate the toxicity of the radiotherapy to the brain and compare with known toxicities of radiotherapy to the brain in melanoma and brain metastases. To use the data generated to plan definitive controlled clinical trials of the combination. To determine the overall response rate (Phase II component).
Phase I Dose Escalation in Patients With 1-3 Unresectable Brain Metastases
Brain MetastasesBrain metastases occur in 20-40% of patients with metastatic cancer. The standard treatment is based on whole brain radiation therapy and local treatment of metastases as neurosurgery or radiosurgery. However, many cases can not receive a standard local treatment, and local relapse occurs in almost 50% of cases treated with only whole brain irradiation. There are retrospective studies of increased radiation dose at the site of metastasis with hypofractionated stereotactic radiotherapy (HSRT) with favorable results, but there are no controlled studies regarding the safety of radiation dose in these situations. This study is a phase I study to evaluate the maximum tolerance dose (MTD) with HSRT as a way to increase the dose of radiation after the WBRT for patients with 1-3 brain metastases not eligible for surgery or RS.
Safety of Dabigatran Etexilate in Blood Clot Prevention in Children
Venous ThromboembolismSecondary PreventionThis open-label, single arm prospective cohort study will assess the safety of dabigatran etexilate in secondary prevention of venous thromboembolism in paediatric patients. Children from 0 to less than 18 years of age will be eligible to participate.
Detection Rate of Liver Metastases With Contrast Enhanced Intraoperative Ultrasound Compared to...
Colon Cancer Liver MetastasisContrast Enhances Intraoperative Ultrasound2 moreThe study compares the established imaging techniques (CT, MRT, Contrast Ultrasound) with the new method of intraoperative contrast enhanced ultrasound to compare all methods for their rate of detection of colorectal liver metastasis.
Perioperative Treatment of Resectable Liver Metastases
Colon Cancer Liver MetastasisThis randomized, controlled, multicenter, non-comparative phase II trial compares an intensified perioperative treatment of patients with resectable synchronous or metachronous colorectal liver metastases to primary surgery and adjuvant systemic chemotherapy.
Predictive Value of 99mTc- Albumin Spheres Before 90Y- SIR Therapy
Colorectal CancerLiver MetastasesThe purpose of this study is to assess the predictive value of 99mTechnetium (Tc)- labeled albumin in macroaggregates (MAA) and in microspheres (B20) injected into the common hepatic artery for the distribution of 90Yttrium- Selective Internal Radiotherapy (SIRT)-spheres (SIR- spheres).
Dose Escalation Study to Evaluate the Penetration and Pharmacodynamic Effects of Baminercept in...
Secondary Progressive Multiple SclerosisThis is a prospective, randomized, multicenter, dose escalation study to determine subject safety, pharmacokinetic, and pharmacodynamic responses in patients with SPMS
Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease
Leptomeningeal MetastasesThis pilot clinical trial studies continuous intraventricular methotrexate in treating patients with leptomeningeal disease. Drugs used in chemotherapy, such as methotrexate, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving drugs directly into the ventricles may be an effective treatment for patients with leptomeningeal disease