Robotic-Assisted Surgery in Treating Patients With Spine Tumors
Adult Spinal Cord NeoplasmSpinal Bone Metastases1 moreThis pilot clinical trial studies robotic-assisted surgery in treating patients with spine tumors. Robotic-assisted surgery is a less invasive type of surgery for spine tumors and may have fewer side effects and improve recovery
Four Week, Pharmacodynamic/Pharmacokinetic, Efficacy, and Safety Study of Lunacalcipol (CTA018)...
Stage 5 Chronic Kidney Disease (CKD)Secondary Hyperparathyroidism (SHPT)1 moreOpen-label, pharmacodynamic, safety, pharmacokinetic and efficacy study of Lunacalcipol Injection.
Genistein in Treating Patients Undergoing External-Beam Radiation Therapy for Bone Metastases
Breast CancerKidney Cancer5 moreRATIONALE: Genistein may increase the effectiveness of radiation therapy in treating pain caused by bone metastases. PURPOSE: This phase I/II trial is studying the side effects of genistein and to see how well it works in treating patients undergoing external-beam radiation therapy for pain caused by bone metastases.
Screening Non Small Cell Lung Cancer With Bone Metastasis and Efficacy and Safety Research of Receiving...
Non-small Cell Lung CancerBone MetastasesA multicenter Prospective Study to assess the screening methods, parameter of NTX and the efficacy and safety of zoledronic acid treatment in addition to anti-tumor therapy in patients of non-small cell cancer with bone metastasis in china.
Study Comparing Radio Frequency Ablation Plus Chemotherapy and Chemotherapy Alone in Patients With...
Metastatic Liver CancerSecondary Liver Cancer1 moreThe purpose of this study is to determine whether patients treated with Radiofrequency Ablation (RFA) in conjunction with chemotherapy have a better overall survival rate than patients treated with chemotherapy alone.
Magnetic Resonance Imaging in Measuring the Effect of Cabozantinib in Patients With Castrate Resistant...
Bone MetastasesCastrate-resistant Prostate Cancer2 moreThis study is being done to help researchers understand more about prostate cancer that has spread to the bones by using the newest magnetic resonance imaging (MRI) techniques and to better understand the effect of an experimental drug called XL184 (or cabozantinib) on bone disease. The other purposes of the study are to better understand the effect of XL184 on prostate cancer progression, bone pain, and on any cancer cells that patients may have circulating within the blood (called circulating tumor cells)
Treatment of Patients With Donor Lymphocytes Sensitized by Antigens Expressed by the Host
Hematological MalignancyNeoplasm MetastasisAllogeneic stem cell transplantation is the only effective treatment to patients resistant to conventional chemotherapy. Donor lymphocytes infusion (DLI) serve as a routine treatment of choice for patients relapsing following allogeneic stem cell transplantation. The present proposal is presented for introducing the use of immune rather than naive donor lymphocytes for patients with resistant relapse and resistant to DLI. DLI primed in-vitro against tumor cells of host origin or against host alloantigens presented by parental alloantigens in one way mixed lymphocytes culture can induce much more than potent graft-vs-leukemia and graft-vs-tumor effects, while down-regulating graft-vs-host disease (GVHD).
Prediction of Drug Response Using an Ex Vivo Organ Culture (EVOC) on Fresh Human Tumour Samples...
Advanced CancerMetastatic CancerThe primary objective of this study is to determine how sensitive and specific the Curesponse Ex Vivo Organ Culture (EVOC) model is at predicting a patient's clinical response to a specific cancer therapy. 248 patients from participating UK hospitals will have a biopsy for the development of an Ex-vivo organ culture at the Curesponse Laboratory. Patients will have standard of care anticancer therapy after the biopsy and be followed up for 6 months following their biopsy. The combined results of the study will show whether the EVOC has potential to be useful for future patients prospectively in determining whether a certain clinical treatment is likely to benefit them.
Changes in Coagulation in Colorectal Cancer Patients Undergoing Surgical Treatment
Peritoneal MetastasesPeritoneal Carcinomatosis13 moreCytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) has prolonged the survival substantially for selected patients with peritoneal metastases from colorectal cancer.Bleeding and thromboembolic disease have been reported as postoperative complications related to this advanced open surgical treatment. However, perioperative changes in coagulation and fibrinolysis are only sparsely reported in the literature.The mainstay of treatment with curative intend of none-advanced colorectal cancer is minimally invasive laparoscopic surgery followed by adjuvant chemotherapy. The approach is considered associated with a lower risk of thromboembolic disease than open surgery. Despite differences in extent of surgery and thromboembolic risk the same extended thromboprophylaxis regimen for 28 days is currently prescribed to patients undergoing cytoreductive surgery with HIPEC as well as minimally invasive rectal cancer resection. This study aims to investigate all parts of the coagulation system and fibrinolysis, and thereby thromboembolic risk and potential bleeding in two groups of patients with different extent of surgical trauma: 1) Colorectal cancer patients undergoing cytoreductive surgery with HIPEC and 2) rectal cancer patients undergoing minimal invasive rectal cancer resection. Our hypothesis is that patients undergoing cytoreductive surgery with HIPEC are exposed to more aggravated alterations of coagulation and fibrinolysis than patients undergoing minimally invasive rectal cancer resection.
Validation of a Multitask Deep Learning System at Spine Metastasis CT
To Evaluate the Spinal Instability Detection Performance of the DLSThe multitask deep learning system (DLS) with five algorithms detecting five quantitative factors of Spinal Instability Neoplastic Score (SINS) was developed. Radiologists and oncologists from multicenter will be recruited to read the CT scans in picture archiving and communication system (PACS) independently, comparing with the DLS. One month after reading the CT scans in PACS, the participants will also asked to perform a web-based test in the DLS website using the same CT scans. Area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of the DLS were calculated with professional graders as the reference standard.