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Active clinical trials for "Migraine Disorders"

Results 261-270 of 1206

Non-invasive Neurostimulation for the Relief of Migraine

Migraine

The purpose of this feasibility study is to gather preliminary information on the safety and effectiveness of patient self-administration of a noninvasive neurostimulation of the vagus nerve using the GammaCore device for the treatment of pain and allodynia symptoms associated with acute migraine in adults.

Terminated26 enrollment criteria

A Research Study Examining the Use of Olanzapine for the Prevention of Migraine

Migraine

Olanzapine (o-lan-zah-peen) is a medication that has been approved by the Food and Drug Administration (FDA) for the treatment of patients with schizophrenia and/ or bipolar disorder. The trade name for this drug is Zyprexa®. Olanzapine has not been approved by the FDA for the prevention of migraine and is experimental for the purposes of this research study. The Jefferson Headache Center at Thomas Jefferson University has developed this clinical study to evaluate the safety and effectiveness of Olanzapine in preventing migraine headaches.

Terminated17 enrollment criteria

Safety and Efficacy of Nerivio™ for the Acute Treatment of Migraine in Adolescents

Acute Migraine

Nerivio™ is an FDA-authorized remote electrical neuromodulation (REN) device for the acute treatment of migraine with or without aura in patients 18 years old or above who do not have chronic migraine. The device delivers transcutaneous electrical stimulation to the upper arm to induce conditioned pain modulation (CPM) that activates a descending endogenous analgesic mechanism. This is a prospective, single arm, open label, multicenter trial of the safety and efficacy of Nerivio™ for the acute treatment of migraine in adolescents The study will be conducted in three phases: Phase I - Run-in: Phase II - Treatment phase: Phase III (optional) - Free-use

Terminated17 enrollment criteria

Feasibility of Using a Mobile Device Controlled Micro-pressure Pulse Insufflator for Acute Migraine...

Migraine

Evaluate the feasibility of using a mobile interface to control the insufflator device administering treatment for aborting (stopping) an acute episode of migraine. The patient, under clinical supervision, will use the mobile interface to "self administer" the treatment when experiencing an acute episode of migraine. The supervising clinician will monitor the patient and the device to make sure that no harm could come to the patient and will be ready to intervene if any adverse effects were suspected to or in the process of happening.

Terminated3 enrollment criteria

Treatments of Migraine With Triptans in Individuals With Elevated Cardiovascular Risk and in Pregnant...

MigraineCardiovascular Diseases1 more

Researchers are evaluating the safety of triptan treatment of migraine in individuals with elevated cardiovascular risk and in pregnant women.

Active15 enrollment criteria

Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the...

HeadacheMigraine

Metoclopramide (Reglan) is a common agent used for relief of headaches in the emergency department (ED).In this study the investigators seek to explore another option for treatment of headaches in the ED, one that may be more efficacious and efficient. Haloperidol (Haldol), a butyrophenone class of medication, is thought to act by affecting the dopamine 2 receptor in the brain. By exploring haloperidol as an option for treatment, the investigators hope to discover a more efficient and effective medication for the treatment of non-traumatic headaches, thereby decreasing a patient's length of stay in the department and decreasing the rate of return visits for continued discomfort from the same headache. This study could lead to the increased usage of haloperidol as a first line agent in the treatment of prolonged headaches presenting to the ED.

Terminated14 enrollment criteria

A Non-Invasive Neuromodulation Device for Prevention of Episodic Migraine Headache

Intervention

This study will assess the efficacy of a neuromodulation device for the treatment of episodic migraine headache.

Terminated29 enrollment criteria

Spectacle Tints and Thin-Films for Migraine

Headache Migraine Chronic

Nearly all migraine sufferers report sensitivity to light during a headache and a significant proportion of sufferers report light sensitivity between attacks. Light is also a common trigger for migraine headaches. Spectacle lenses that have been treated with tints and spectacle lenses that have been treated with thin-films have both been shown to reduce light sensitivity and headache in patients with migraine. At this time, it is not clear which spectacle lens treatment is superior. The purpose of this trial is to determine if there's a significant, therapeutic advantage to either spectacle lens treatment. Both treatments could be a novel, non-invasive adjuvant in the treatment of migraine.

Terminated7 enrollment criteria

Study of Occipital Nerve Stimulation for Drug Refractory Migraine

Migraine

The purpose of this study is to evaluate the safety and effectiveness of an implantable device to treat migraine. There are a significant number of patients who have drug refractory migraine and alternative therapies are needed.

Terminated16 enrollment criteria

Occipital Nerve Stimulation (ONS) for Migraine: OPTIMISE

Migraine Disorders

The primary objective of this study is to evaluate the safety and efficacy of occipital nerve stimulation (ONS) using the Boston Scientific Corporation (BSC) Precision™ System in the management of intractable chronic migraine, when used in conjunction with anti-migraine medications.

Terminated16 enrollment criteria
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