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Active clinical trials for "Mitral Valve Insufficiency"

Results 31-40 of 367

Early Versus Deferred Aortic Valve Replacement in Patients With Moderate Aortic Stenosis and Mitral...

Aortic Valve Replacement in Patients With Moderate Aortic Stenosis Combined With Mitral Regurgitation

The aim of the present study is to investigate safety and efficacy of early versus deferred aortic valve replacement in patients with moderate aortic stenosis combined with moderate mitral regurgitation.

Recruiting18 enrollment criteria

Transcatheter Mitral Valve Repair for the Treatment of Mitral Valve Regurgitation In Heart Failure...

Ventricular RemodelingLeft

The study compares the effectiveness of treatment with MitraClip to medical therapy in improving the reduction of cardiovascular morbidity and functional capacity at 24 months, in patients with moderate functional mitral regurgitation.

Recruiting53 enrollment criteria

Improving Mitral Repair for Functional Mitral Regurgitation

CardiomyopathyCardiovascular Diseases5 more

The investigators are interested in determining the best surgical technique to correct functional mitral regurgitation, as there is currently not one technique that is established to work better than the other. The technique used in current clinical practice is undersizing mitral annuloplasty (UMA), in which a prosthetic ring is implanted onto the mitral valve to correct the leakage. Though widely adopted, durability of the repair is less, as 58% of the patients present with recurrent FMR within 2 years. There are no specific algorithms to predict who might have UMA failure, but research indicates that some geometric indices might be strong predictors. The investigators are interested in testing the hypothesis that, elevated lateral inter-papillary muscle separation (IPMS) is a predictor of post-UMA recurrence of FMR at 12 months. In the first part of this study, the study team will measure lateral IPMS before surgery, and relate to post-surgery FMR severity at discharge/30 days, 6 months and 12 months. A relatively newer technique is papillary muscle approximation (PMA), in which a suture draws together the two muscles that connect the mitral valve to the heart muscle prior to performing UMA. This reduces the lateral inter-papillary muscle separation (IPMS) and is expected to improve the durability of UMA. In the second part of this study, the investigators will perform PMA and UMA together and determine if FMR severity is reduced at discharge/30 days, 6 months and 12 months.

Recruiting12 enrollment criteria

Multicentre Study of MITRACLIP® Transcatheter Mitral Valve Repair in Patients With Severe Primary...

Mitral Regurgitation

The objective of the study is to demonstrate the non-inferiority for clinical efficacy of an endovascular treatment strategy with the MitraClip® in comparison with a surgical treatment strategy in patients with severe primary mitral regurgitation judged eligible for anatomical repair with the MitraClip® or mitral valve surgery with high surgical risk. This trial is a French and Monegasque, multicenter and randomized trial. Patients enrolled will be clinically followed for 2 years ( clinical visit at 1 month, at 6 months and 12 months, phone call at 18 months and clincial visit at 24 months).

Recruiting33 enrollment criteria

VenTouch OUS Feasibility Study

Functional Mitral Regurgitation

This is a prospective, multi-center, single-arm study to evaluate safety and efficacy of the VenTouch System for treatment of subjects with functional MR.

Recruiting40 enrollment criteria

AltaValve Early Feasibility Study Protocol

Mitral RegurgitationMitral Insufficiency3 more

Prospective, single-arm, multicenter study to evaluate the safety and performance of the AltaValve for the treatment of moderate to severe or severe mitral valve regurgitation in subjects who are considered high risk for mortality and morbidity from conventional open-heart surgery.

Recruiting16 enrollment criteria

An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement...

Mitral Regurgitation

Study to evaluate the feasibility, safety and performance of the HighLife trans-septal Transcatheter Mitral Valve in patients with moderate-severe and severe mitral regurgitation who are at high risk for surgical treatment.

Recruiting17 enrollment criteria

Mi-thos® Transcatheter Mitral Valve Replacement Study

Mitral Valve Regurgitation

To evaluate the safety and performance of the Mi-thos® Mitral Heart Valve with the Mi-thos® Transcatheter Delivery System.

Recruiting24 enrollment criteria

Percutaneous or Surgical Mitral Valve Repair

Mitral Valve Regurgitation

This is a prospective, multicenter, open-label, randomized trial comparing mitral valve (MV) transcatheter edge-to-edge repair (TEER) to surgical repair (1:1 ratio) in patients with primary, degenerative mitral regurgitation (MR). The trial will be conducted in the U.S., Canada, Germany and the United Kingdom, and is designed as a strategy trial. Thus, all devices legally marketed for TEER of primary degenerative MR in a particular country are eligible to be used in this trial.

Recruiting27 enrollment criteria

Valveclip® Transcatheter Mitral Valve Repair Study

Mitral Regurgitation

The purpose of this clinical trial is to evaluate the effectiveness and safety of the transcatheter mitral valve repair system in the treatment of patients with moderate or above degenerative mitral regurgitation.

Recruiting25 enrollment criteria
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