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Active clinical trials for "Mitral Valve Insufficiency"

Results 21-30 of 367

Cardiovalve Transfemoral System - FIM Study

Mitral Regurgitation

The Cardiovalve system is a replacement valve delivered through a transfemoral access and transseptal approach and is intended for symptomatic patients with Mitral regurgitation for whom surgical options are not feasible.

Recruiting37 enrollment criteria

Safety and Effectiveness Study of Dragonfly System for Functional Mitral Regurgitation

Mitral Regurgitation Functional

To confirm the effectiveness and safety of the Dragonfly transcatheter mitral valve repair system for the treatment of chronic moderate to severe (3+) or severe (4+) functional mitral regurgitation (FMR) who remained clinically symptomatic after guideline-directed medical treatment.

Recruiting35 enrollment criteria

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

Mitral Annular CalcificationMitral Stenosis2 more

A prospective multicenter study enrolling high surgical risk patients with severe mitral annular calcification (MAC) and symptomatic mitral valve disease. There are 2 arms in this study: Transseptal Valve-in-MAC (ViMAC) and a control arm of patients treated with medical treatment only which will include patients who can't be treated due to the presence of anatomical exclusion criteria or other exclusion criteria.

Recruiting39 enrollment criteria

Watchman for Patients With Atrial Fibrillation Undergoing Transcatheter Mitral Valve Repair (WATCH-TMVR)...

Nonvalvular Atrial FibrillationSevere Degenerative Mitral Regurgitation

WATCH-TMVR (Watchman for Patients with Atrial Fibrillation Undergoing Transcatheter Mitral Valve) Clinical Trial have the main objective to assess the feasibility of combining clinically indicated MitraClip TMVR and Watchman LAAO in one setting.Mayo Clinic will be the data coordinating center for this trial, which will include up to 3 sites.

Recruiting20 enrollment criteria

Mi-STITCH™ and Mi-KNOT™ Device Technologies - Improvement of Mitral Valve Repair

Mitral RegurgitationMitral Valve Insufficiency

The objective of this study is to analyze the safety and efficacy of a novel device for minimally invasive mitral valve repair. Data of the early and intermediate postoperative period will be collected within routine clinical follow-up in order to assess morbidity and mortality as well as echocardiographic parameters.

Recruiting16 enrollment criteria

TVMR With the Innovalve System Trial - First In Human Israel

Mitral Valve Regurgitation (Degenerative or Functional)

Study to evaluate the safety and performance of the Innovalve mitral valve replacement system

Recruiting6 enrollment criteria

TVMR With the Innovalve System Trial - Pilot in Georgia

Mitral Valve Regurgitation (Degenerative or Functional)

Study to evaluate the safety and performance of the Innovalve mitral valve replacement system

Recruiting6 enrollment criteria

First-In-Human Clinical Study for Treatment of Severe Mitral Valve INsufficiency With Epygon™ TRanscatheter...

Mitral Valve Regurgitation

The EPYGON VALVE is an innovative mitral valve, intended for valve replacement of a native mitral valve through a minimally invasive implant procedure by means of a dedicated implant device. The EPYGON VALVE is a bio prosthesis, composed by a functional assembly of bovine pericardium on a NiTinol stent. The purpose of this trial is to assess the safety and feasibility of the Epygon™ Transcatheter mitral valve and the transapical delivery system, in adult patients with severe, symptomatic mitral regurgitation.

Recruiting37 enrollment criteria

Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following...

Heart FailureMitral Regurgitation

This is an investigator initiated, prospective study to demonstrate the safety and feasibility of implantation of the V-Wave Interatrial Shunt System (herein called the "V-Wave Shunt" in patients immediately following percutaneous mitral valve repair using the MitraClip system.

Recruiting58 enrollment criteria

Cephea Early Feasibility Study

Mitral Regurgitation

The objective of this study is to evaluate the preliminary safety and effectiveness of the Cephea Mitral Valve System for the treatment of symptomatic patients with mitral regurgitation ≥ Grade III in whom transcatheter therapy is deemed more appropriate than open heart surgery.

Recruiting7 enrollment criteria
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