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Active clinical trials for "Mitral Valve Insufficiency"

Results 221-230 of 367

Beating Versus Arrested Heart for Mitral Valve Replacement

Mitral StenosisMitral Insufficiency

The purpose of this study is to evaluate the immediately clinic and ultramicroscopic myocardial cellular ischemia and reperfusion to replace of the mitral valve using arrested heart versus on-pump empty beating heart surgical techniques.

Completed10 enrollment criteria

Genomic Investigation of Cardiovascular Diseases

Coronary Artery DiseaseMyocardial Infarction4 more

This proposal puts forward a research plan to initiate a genetic databank, henceforth referred to as The Genebank at Scripps Clinic Registry. This database will usher in genomic research at Scripps as we strive to stay at the forefront of cardiovascular research in the new century. Human subject donation allows for the creation of the proposed genebank.

Active66 enrollment criteria

Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With...

Mitral Valve InsufficiencyCoronary Artery Disease

People with coronary artery disease (CAD) or people who have had a heart attack may develop a leak in the mitral valve of their heart and may therefore need to undergo surgery to fix the valve. The best way to fix the mitral valve remains undetermined. This study will evaluate whether it is better for people with severe mitral valve leakage to undergo a mitral valve replacement procedure or a mitral valve repair procedure.

Completed19 enrollment criteria

CG Future® Annuloplasty Ring/Band Clinical Trial

Mitral Valve Insufficiency

The primary goal of the study is to document the number of patients that are successfully implanted and benefit from the implantation of both a CG Future Annuloplasty ring or a band.

Completed8 enrollment criteria

CARDINAL Adjustable Annuloplasty Ring System For Treatment of Mitral Regurgitation

Mitral Valve Insufficiency

Annuloplasty device for repair of mitral valve regurgitation with option to adjust device post implant off pump, to optimize correction of mitral regurgitation. Unlike conventional annuloplasty ring, the Cardinal system offers the clinician the opportunity to make adjustments after weaning from cardiopulmonary bypass. Adjustability is expected to reduce the number of patients leaving the operating room with residual regurgitation after mitral valve repair.

Completed14 enrollment criteria

Incidence of Significant Mitral Regurgitation in Acute Heart Failure Patients

Acute Heart FailureMitral Regurgitation

The purpose of this study is to determine the prevalence of moderate-to-severe Mitral Regurgitation (MR) in acute Heart Failure (HF) patients requiring hospital admission.

Completed3 enrollment criteria

Safety and Performance of the AccuCinch® System

Heart FailureMitral Valve Insufficiency

This is a single-arm, multi-center, open-label controlled study that will assess the safety and performance of the Accucinch System to induce left ventricular reverse remodeling and reduce the severity of functional mitral regurgitation in symptomatic adult patients with mitral regurgitation and left ventricular remodeling due to dilated cardiomyopathy (ischemic or non-ischemic etiology), who are of high operative risk.

Withdrawn37 enrollment criteria

Feasibility Study of Patients With Severe MR Treated With the Cardiovalve TMVR System

Mitral Regurgitation

The study will test the safety and performance of the Cardiovalve transfemoral mitral valve replacement system in treating patients with severe mitral regurgitation who are at high risk for open chest surgery. The system is comprised of comprised of: 1) an Implant; 2) a Delivery System (DS); and 3) Accessories that are required for the implantation procedure. the procedure is performed under general anesthesia.

Withdrawn38 enrollment criteria

Effects of Mitral Valve Repair With the Geoform Ring on Cardiomyopathy

Mitral Valve RegurgitationCongestive Heart Failure1 more

The primary aim of this study is to assess the changes on the shape and function of the left ventricle in patients with severe mitral valve regurgitation due to congestive heart failure and cardiomyopathy who undergo mitral valve reconstruction with a Geoform ring. Three-dimensional echocardiogram will be used for precise evaluation of the shape and function of the ventricle.

Withdrawn16 enrollment criteria

Early Feasibility Study of the CardiAQ™ TMVI System (Transfemoral and Transapical DS)

Mitral InsufficiencyHeart Valve Disease2 more

The purpose of the study is to generate early US feasibility data of the CardiAQ™ Transcatheter Mitral Valve Implant System. The study will enroll patients with moderate to severe mitral valve regurgitation who are considered high risk for mortality and morbidity from conventional open-heart surgery.

Withdrawn6 enrollment criteria
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