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Active clinical trials for "Motor Neuron Disease"

Results 441-450 of 760

Efficacy and Safety of Plasma Exchange With Albumin in Patients With Amyotrophic Lateral Sclerosis...

Amyotrophic Lateral Sclerosis

Pilot, phase II, prospective, open-label, uncontrolled study of plasma exchange with 5% albumin in 10 subjects having a definite, possible, or probable diagnosis of Amyotrophic Lateral Sclerosis (ALS).

Completed19 enrollment criteria

Influence of G-CSF and EPO on Associative Learning and Motor Skills

Chronic StrokeAmyotrophic Lateral Sclerosis

In the study we want to prove whether the subcutaneous application of granulocyte-stimulating factor (G-CSF) and erythropoetin (EPO) influence associative learning and/or motor skills of patients, who suffer from chronic stroke or amyotrophic lateral sclerosis. The study hypothesis is that G-CSF and EPO improve associative learning and/or motor skills.

Completed14 enrollment criteria

Insulin-like Growth Factor-1 in Amyotrophic Lateral Sclerosis (ALS) Trial

Amyotrophic Lateral Sclerosis

The purpose of this multicenter study is to determine if insulin-like growth factor-1 (IGF-I) slows the progressive weakness in amyotrophic lateral sclerosis (ALS) patients. Study participants will be followed for 2 years once enrolled. They will receive either placebo or the active IGF-I. Examinations will take place at approximately 6-month intervals.

Completed21 enrollment criteria

Frequency of SOD1 and C9orf72 Gene Mutations in French ALS

Amyotrophic Lateral Sclerosis

The purpose of the study is to determine the frequency of mutations in the C9orf72 and SOD1 genes in the incident population of ALS patients followed in the FILSLAN centres

Active7 enrollment criteria

Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II)

Amyotrophic Lateral Sclerosis

This study will try to understand the difference in brain structure between ALS patients and healthy people of similar age. ALS is a condition affecting the nervous system with disruption of the brain networks. This study aims to understand these disruptions and determine their significance in ALS.

Active8 enrollment criteria

R(+) Pramipexole in Early Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

The hypothesis of this study is that treatment with R(+) pramipexole at 30 mg/day will alter the slope of decline in ALS functional rating scale over the course of 6 months. ALS patients at an early stage of disease will be observed for 3 months after enrollment and then treated with drug for 6 months.

Completed2 enrollment criteria

Placebo Controlled Study of ONO2506PO in the Presence of Riluzole in Patients With Amyotrophic Lateral...

Amyotrophic Lateral Sclerosis (ALS)

The purpose of this study is to determine if oral treatment with ONO-2506PO in patients diagnosed with ALS, who have had onset of muscle weakness within 14 months of randomization, could lead to the slowing of decline in respiratory function, functional status, muscle strength, quality of life and survival compared with placebo group.

Completed5 enrollment criteria

"New Perspectives of Adaptation to NIV in ALS"

Amyotrophic Lateral Sclerosis (ALS)

The purpose of this study is to demonstrate that the adaptation to the Non Invasive Ventilation (NIV) at home is not worse when compared with an adaptation performed in inpatient settings.

Completed10 enrollment criteria

PRE-Symptomatic Studies in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

The goal of PRESS-ALS is to study the earliest manifestations of disease in people with early ALS in whom some areas of the body are not yet affected.

Active14 enrollment criteria

Polysomnography-directed Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis (ALS)

Use of noninvasive ventilation (NIV, also known colloquially as "Bipap") has been associated in some studies with improvement in pulmonary function, quality of life and survival. NIV is typically applied during sleep, and without the benefit of sleep study to determine the optimal settings. The investigators have shown that when NIV is used in this fashion, failure of nocturnal oxygenation and ventilation is prominent. This study is randomizing patients to standard application of NIV vs application guided by use of sleep study data to determine the effect of titrated therapy on pulmonary function, quality of life and survival.

Terminated7 enrollment criteria
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