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Active clinical trials for "Multiple Myeloma"

Results 2851-2860 of 3165

Autologous Stem Cell Transplant (ASCT) With Intravenous Busulfan and Melphalan as Conditioning Regimen...

Multiple Myeloma

Analyze the results of ASCT using intravenous Busulfan and Melphalan as conditioning regimen for patients with Multiple Myeloma.

Unknown status17 enrollment criteria

Auto-Allo Tandem Stem Cell Transplantation for Patients With Multiple Myeloma

Multiple Myeloma

The present study will be a multicenter, prospective phase II-study investigating safety and efficacy of the combination of auto-allo tandem stem cell transplantation in patients with multiple myeloma and age of >_60 years, followed by maintenance therapy with low-dose Thalidomide and Donor Lymphocyte Infusions.

Unknown status16 enrollment criteria

Study of Fluphenazine in Relapsed or Relapsed-and-Refractory Multiple Myeloma

Multiple Myeloma

The purpose of this study is to evaluate the safety and tolerability of fluphenazine in patients with advanced multiple myeloma. The study will also describe the efficacy of this drug.

Unknown status30 enrollment criteria

Autologous Bone Marrow Transplantation (BMT) Compared With Allogeneic BMT in Multiple Myeloma

Multiple Myeloma

A prospective, randomized trial of autologous bone marrow transplantation compared with allogeneic bone marrow transplantation in multiple myeloma.

Unknown status24 enrollment criteria

Study of the Best Timing for Plerixafor in Autologous Hematopoietic Stem Cell Collection

Multiple MyelomaNon-Hodgkins Lymphoma

The purpose of this study is to determine whether it is safe and effective to collect peripheral blood hematopoietic stem cells 16 hours rather than the usual 11 hours after administration of plerixafor.

Unknown status37 enrollment criteria

Third-line Therapy of Multiple Myeloma a Prospective Phase I /II Trial

Multiple Myeloma

To investigate the effect of an anti-inflammatory therapy consisting of lenalidomide in combination with pioglitazone, dexamethasone and metronomic low-dose chemotherapy with treosulfan on the response rate in patients with relapsed or refractory or progressive multiple myeloma(MM). Phase I: to determine the lenalidomide dse for the phase II part (5 mg or 10 mg or 15 mg) on the basis of dose-limiting toxicities (DLTs') in the first 4 weeks of treatment. Phase II: to determine response rate (primary objective) time to progression (TTP) time to partial response (TPR) overall survival (OS) quality of life tolerability and safety

Unknown status63 enrollment criteria

Bortezomib and High-dose Melphalan at Myeloma Relapse

Multiple Myeloma

The prognosis after retreating with high-dose melphalan with stem cell support after first relapse after high-dose treatment is dependent on the time to first relapse. Bortezomib can increase chemosensitivity of e.g. melphalan. The trial aims at determining the toxicity of adding bortezomib to high-dose melphalan with stem cell support and evaluating whether the time to a second relapse can be prolonged.

Unknown status17 enrollment criteria

A Pilot Study of the Combination of Melphalan, Bortezomib, Thalidomide and Dexamethasone (MEL-VTD)...

Multiple Myeloma

In this study, researchers want to find out if using the VTD regimen, along with higher doses melphalan, in subjects who have relapsed or progressed after previous transplant(s), can be given safely to subjects who have failed previous transplant(s).

Withdrawn20 enrollment criteria

High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Newly Diagnosed Stage...

Multiple Myeloma and Plasma Cell Neoplasm

RATIONALE: Drugs used in chemotherapy, such as melphalan, use different ways to stop cancer cells from dividing so they stop growing or die. Stem cell transplant using stem cells from the patient may be able to replace immune cells that were destroyed by chemotherapy used to kill cancer cells. Giving colony-stimulating factors, such as G-CSF or pegfilgrastim, helps stem cells move from the bone marrow to the blood so they can be collected. It is not yet known which regimen is more effective in treating multiple myeloma. PURPOSE: This randomized phase II trial is studying how well high-dose chemotherapy followed by stem cell transplant works in treating patients with newly diagnosed stage I, stage II, or stage III multiple myeloma.

Unknown status33 enrollment criteria

VELCADE as Maintenance Treatment in Patients With Multiple Myeloma Following Autologous Peripheral...

Multiple Myeloma

Protocol DSMM VIII is a multi-center, open-label study evaluating the safety and tolerability, as well as the efficacy, of maintenance treatment with VELCADE (bortezomib) in patients with multiple myeloma with detectable disease activity following tandem high-dose chemotherapy and autologous SCT. The time from SCT to the initiation of VELCADE treatment will be 3 to 6 months.

Unknown status19 enrollment criteria
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