Inflammation and the Host Response to Injury (Trauma)
TraumaBurns1 moreThe purpose of this study is to help improve our understanding of the biology involved in the body's response to serious trauma or burn injury. The host response to trauma and burns is a collection of physiological and pathophysiological processes that depend critically upon the regulation of the human innate immune system, with particular emphasis on the inflammatory component of that system. No single research center or small group of centers has the capacity to delineate the integrated response of this complex biological system, which involves multiple molecular and genetic interactions that vary in time. Our proposal promotes the identification of important dynamic relationships that regulate the integration of this complex biological system, with the expectation that this understanding will ultimately impact the diagnosis, prognosis, and treatment of the hospitalized, severely injured patient.
Autologous Stem Cells in Newborns With Oxygen Deprivation
Apgar; 0-3 at 1 MinuteMetabolic Acidosis3 moreThe purpose of this study is to determine whether the plasticity of autologous intravenous application of cord blood stem cells would improve the clinical course of asphyxiated newborns.
The Pharmacokinetics of Fentanyl in Intensive Care Patients
Multiple Organ FailureCritical Care1 moreThis study is part of a project intended to develop guidelines to optimise the dosing of fentanyl in intensive care patients. This study will focus on determining: Whether the pharmacokinetics of fentanyl change during the ICU stay. To what extent / the degree of change in fentanyl pharmacokinetics in ICU patients. Which factors (e.g. physiological variables) that cause such a change. Based on simulations, determine context-sensitive half-times of fentanyl in ICU patients.
Evaluation of the Efficacy and Safety of Extracorporeal Support With Hemoperfusion in Critical Patients...
HemoperfusionMultiorgan Failure1 moreLow-level interventional clinical trial to evaluate the effectiveness and safety of extracorporeal support with hemoperfusion in critical patients with multiorgan dysfunction syndrome by septic origin.
DNA Damage in Critically Ill COVID-19 Patients
Covid19Organ Failure2 moreCritically ill patients with COVID-19 are exposed to high oxidative stress which is potential harm to the DNA. Peripheral lymphocytes' DNA will be investigated using the comet assay on changes in oxidative damage to the purine and pyrimidine bases and single-stranded DNA breaks.
ProAdrenomedullin Assessment of Multi-Organ Failure in COvid-19 Sepsis
Covid19COVID-19 is a worldwide pandemic. Around 5% of infected patients are admitted in ICU, mainly for respiratory failure. Outcome of these patients is linked to other organ failures. Optimal therapies are not defined so far. The sponsor want to assess the role of MR-ProADM as prognostic biomarker, and the impact of treatments (including supportive treatments) on MOF occurrence and outcome.
NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock
SIRSSepsis3 moreThe purpose of this study is to determine the course of NT-proBNP plasma concentrations in the context of confounding parameters in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
Evaluation of Corrected Carotid Flow Time Variations During Passive Leg Lift to Predict Response...
Organ FailureMultiplePatients hospitalized in intensive care often require intravenous administration of fluid in order to optimize the functioning of the heart and thus ensure perfusion of vital organs such as the kidneys, the brain or the digestive tract. However, it is necessary to find the right balance in fluid intake because it has been shown that excessive administration has a negative impact on patient survival, the length of their stay in intensive care or the duration of invasive mechanical ventilation.The passive leg lifting maneuver is regularly used to determine which patients should be infused with these large volumes (the patient's chest is placed in a horizontal position and the legs are elevated at 30 ° by tilting the bed for 2 minutes ). To be interpreted, this maneuver requires the presence of invasive devices (bloody arterial pressure catheter, PICCO monitor) or an operator experienced in cardiac ultrasound.Our study aims to evaluate an easy-to-use, non-invasive tool widely available in intensive care and emergency departments (carotid vascular doppler ultrasound) to assess the response to a passive leg lifting maneuver. . The measurements are taken before and after a passive leg lifting maneuver and then before and after a filling decided before inclusion by the doctor responsible for the patient.
PROOF: Pancreatitis-associated Risk Of Organ Failure
PancreatitisOrgan Failure1 moreThis is a prospective case control study that compares the initial immune response with severity and outcome in patients with acute pancreatitis.
Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks.
Critical IllnessMultiple Organ Failure2 moreCritical illness in the ICU setting has high medical and socioeconomic importance. Critically ill patients frequently develop severe neurologic impairment during their course of disease, typically presenting as critical-illness-polyneuropathy (CIP), which is associated with an increased mortality rate. To date neither strategies are available to predict nor to specifically treat CIP. Diagnostic tests to determine CIP during the course of critical illness are available through nerve conduction studies. Further research is needed to find diagnostic tools to identify patients who are on high risk to develop CIP, which could encourage the evolution of new therapeutic strategies for CIP patients. The aims of the study are: An early detection of changes in intramural neuronal networks of human colon samples induced by human blood serum from critically ill patients in order to predict the development of CIP The comparison of different diagnostic tests to diagnose and monitor CIP during the course of critical illness (neurologic examination versus nerve conduction study versus neuromyosonography)