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Active clinical trials for "Multiple Pulmonary Nodules"

Results 131-140 of 153

Prediction Model for Multiple Pulmonary Nodules

Multiple Pulmonary Nodules

This study compares the sensitivity, specificity and accuracy of radiologists, thoracic surgeons and a predictive model (PKUM model) to discriminate malignancy from benign nodules in patients with multiple pulmonary nodules.

Completed6 enrollment criteria

3-D Reconstruction of CT Scan Images in the Evaluation of Non-Specific Pulmonary Nodules

Undiagnosed Pulmonary NodulesLung Nodules

In recent years, more and more people are having lung CT scans performed to screen for various cancers. Many of them have small abnormalities detected, called "nodules", which - for a variety of reasons - doctors are unable to biopsy. As a result, many patients have their CT scans repeated on a regular basis to see if their nodules grow. This process can last several years. Many patients experience significant anxiety during this process, when they are aware of a spot in the lung, but are not told any specific cause. Researchers at Memorial Sloan-Kettering have developed a new way to look at lung nodules in three dimensions. The purpose of this project is to see if any change in the nodules can be detected sooner by this method than by traditional CT scans.

Completed11 enrollment criteria

Granulomatous Pneumocystis Pneumonia

Pulmonary NoduleInvasive Fungal Infections1 more

The intra-alveolar form of Pneumocystis jiroveci pneumonia (PjP) is a common pathology in immunocompromised patients, particularly those infected with HIV. The diagnosis is based on the detection of Pj in a LBA. Intra-tissue granulomatous form (PGP) is a rare entity observed in non-HIV immunocompromised patients. In this case, the LBA is mostly non-contributory and the diagnosis is based solely on the detection of cysts on histological examination on biopsy of a pulmonary nodule. For many years, it has been clearly demonstrated that the use of a specific PCR clearly improves the biological diagnosis of PcP. However, in case of granulomatous form this method is not implemented because the diagnostic hypothesis is not mentioned. In 2018, two cases of PGP were diagnosed at 3-month intervals at Montpellier University Hospital Center. The diagnostic confirmation was obtained with PCR Pj. In this context the investigators will investigate the interest of implementing PCR Pj on biopsies on pulmonary nodules from hospitalized patients between 2015 and 2018. In all selected patients, histopathological aspect of the nodule was compatible with a PGP and, no other diagnosis has been confirmed (infectious, tumoral, inflammatory ...). Finally, 17 patients were selected to check retrospectively, if the presence of Pj could be at the origin of the pathology.

Completed2 enrollment criteria

Early Diagnosis of Small Pulmonary Nodules by Multi-omics Sequencing

CarcinomaNon-small-cell Lung Cancer1 more

Analyse immune repertoire and genetic mutations of benign and malignant pulmonary nodule,and evaluate peripheral blood detection for identifying nature of pulmonary nodule.

Completed6 enrollment criteria

Prospective Post-market Data Collection for Ion Endoluminal System to Understand CT to Body Divergence...

Lung CancerPulmonary Nodule1 more

The goal of this study is to collect post-market data for the Ion Endoluminal System to understand CT to body divergence.

Completed8 enrollment criteria

GE Healthcare VolumeRAD Lung Nodule Detection Study

Pulmonary NoduleSolitary1 more

To perform a multiple reader, multiple case (MRMC) observer study assessing the detection performance of VolumeRAD tomosynthesis of the chest in detecting lung nodules.

Completed10 enrollment criteria

A Pilot Study of PET-CT in the Assessment of Pulmonary Nodules in Children With Malignant Solid...

Pulmonary Nodules

Because the management of children with solid tumors hinges on the extent of disease, it is crucial to identify metastatic sites. Helical chest computed tomography (CT) is the standard method of excluding pulmonary metastases. However, CT lacks molecular information regarding nodule histology and often biopsy is required to exclude malignancy. Biopsy procedures carry known risks including those associated with anesthesia and sedation, infection, pneumothorax, hemorrhage, pain and other post-procedure and post-operative complications and may also add unnecessary cost to the management of the patient. We found that the ability of three experienced pediatric radiologists to correctly predict nodule histology based on CT imaging features was limited (57% to 67% rate of correct classification). Also, there was only slight to moderate agreement in nodule classification between these reviewers. Furthermore, of 50 children who have undergone pulmonary nodule biopsy at St. Jude in the last five years, 44% (22/50) had only benign nodules. Adult studies have shown that a nuclear medicine scan called fluoro-deoxyglucose (FDG) positron emission tomography (PET) and the fusion modality PET-CT are superior to diagnostic CT in distinguishing benign from malignant pulmonary nodules because FDG PET gives information about the metabolic activity of the nodule. Nodules that are malignant have more metabolic activity, hence more FDG uptake/intensity, than those that are benign. There has been little work done in children to determine the value of PET or PET-CT in the evaluation of pulmonary nodules.

Completed3 enrollment criteria

DECAMP-1: Diagnosis and Surveillance of Indeterminate Pulmonary Nodules

Lung Cancer

The goal is to improve the efficiency of the diagnostic follow-up of patients with indeterminate pulmonary nodules by determining whether biomarkers for lung cancer diagnosis that are measured in minimally invasive biospecimens are able to distinguish malignant from benign pulmonary nodules that are incidentally detected in high-risk smokers.

Completed12 enrollment criteria

Evaluate the Utility of the ProLung China Test in the Diagnosis of Lung Cancer

Solitary Pulmonary NoduleMultiple Pulmonary Nodules

A Study to evaluate the utility of the ProLung China Test as an adjunct to CT scan in the diagnosis of lung cancer.

Unknown status10 enrollment criteria

Clinical Study of ctDNA and Exosome Combined Detection to Identify Benign and Malignant Pulmonary...

Pulmonary Nodules

This study through the detection of EGFR、ALK、ROS1、KRAS、HER2、BARF、NTRG1 seven ctDNA and exosome RNA in the blood and alveolar lavage of lung nodules patients and heavy smoking healthy population. If the results of ctDNA test is positive, the target nodule is malignant; if the reaults of ctDNA teste is negatie but exocome RNA is positive, the target nodule is also malignant. If the results of both tests are negtive, the target nodule is recognized as benign. The purpose is study the sensitivity, specificity and diagnostic accuracy of ctDNA and exosome combined detection in the identification of benign and malignant pulmonary nodules. Besides, the diagnostic efficacy of different specimens including blood and alveolar lavage in the identification of benign and malignant pulmonary nodules is also studied.

Unknown status2 enrollment criteria
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