Evaluation of the Effect of AVE0657 in Cheynes-Stokes Breathing Syndrome Patients
Heart FailureSleep Apnea Syndromes1 moreThe primary objective of this study is to assess the activity on breathing parameters of 4 escalating doses of AVE0657 in comparison to placebo in patients with Cheynes-Stokes Breathing Syndrome.
Cardiovascular and Neurohormonal Effects of Faster Atrial Pacing Rate
Heart FailureMany patients with heart failure are unable to increase their heart rate appropriately when their body needs increased blood flow. As a result, they may be unable to mobilize excess fluid that their body retains. We hypothesize that we can provide assistance to their body in mobilizing this fluid by artificially increasing their heart rate using a pacemaker. We plan to conduct a prospective clinical trial to evaluate this hypothesis. We will use a cross over design to study patients who already have biventricular pacemakers implanted or a narrow QRS and volume overload. We will screen them using a blood test that is a rough estimate of volume overload. Patients who meet the inclusion criteria will be randomly assigned to have their pacemakers adjusted or to have no intervention during the first of 2 visits. They will be unaware of which group they are in. Following adjustment, they will be monitored for six hours. Prior to the pacemaker adjustment, several tests will be performed to evaluate heart function and the levels of hormones related that are affected by heart failure. These tests will be repeated at the end of the six hour intervention period in each visit. At the end of the visit patients who had their pacemakers adjusted will have it reset to their original settings.
Oral Tonapofylline (BG9928) in Patients With Heart Failure and Renal Insufficiency
Renal InsufficiencyHeart FailureThe main purpose of this study is to determine the safety and tolerability of tonapofylline (BG9928) when given at different doses to patients with heart failure and renal insufficiency. This study will also explore: Disease related quality-of-life Exercise capacity Renal function Concomitant medications
Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated...
HyponatremiaAcute Decompensated Heart FailureThis study will evaluate the safety and effectiveness of Conivaptan, a vasopressin antagonist, in the treatment of hyponatremic subjects having symptomatic acute decompensated heart failure (ADHF).
Investigating the Role of Impella 2.5 System in Acutely Decompensated Chronic Heart Failure Patients...
Heart FailureThe primary objective of this study is to assess safety and feasibility of IMPELLA 2.5 in Acute Decompensated Heart Failure patients.
Investigational Device Exemption (IDE) Study for the Approval of Closed Loop Stimulation (CLS) and...
Atrial FibrillationCongestive Heart FailureThe purpose of this study is to demonstrate the safety and effectiveness of biventricular pacing over conventional right ventricular pacing in patients with persistent or permanent, symptomatic atrial fibrillation undergoing atrioventricular (AV) node ablation and permanent pacing therapy.
Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in...
Acute Decompensated Heart FailureThe purpose of this prospective, randomized, open-label study is to compare two diuretic strategies in patients with acute decompensated heart failure (ADHF): the addition of an oral thiazide diuretic to intravenous bolus (IVB) loop diuretic will be compared to transition from IVB to continuous infusion (CI) loop diuretic.
Evaluation of Resynchronization Therapy for Heart Failure
Heart FailureHeart failure is a major health problem in Canada. Recent advances in medical and device therapy have helped to reduce the morbidity and mortality of patients with this problem. Among these treatments, cardiac resynchronization therapy (CRT) has very recently been shown to be effective to improve functional class, quality of life and exercise tolerance of the patients with the most severe symptoms of heart failure and a prolonged duration of the QRS on the 12-lead Electrocardiography (ECG).
Dopamine in Acute Decompensated Heart Failure II
Acute Decompensated Heart FailureThe aim of this study is to compare the effects of 1) high-dose furosemide, 2) low-dose furosemide, and 3) low-dose furosemide combined with low-dose dopamine on diuresis, clinical status, renal function, electrolyte balance, length of stay, and 60-day post-discharge outcomes in patients hospitalized with acute decompensated heart failure.
Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV)...
Heart FailureCardiac Failure1 moreThe purpose of the research is to determine if patients have fewer Heart Failure (HF) events after receiving Aquapheresis (AQ) therapy compared to intravenous (IV) diuretics up to 90 days of discharge from the hospital. Heart Failure events are defined as returning to the hospital, clinic or emergency department (ED) for treatment of HF symptoms.