A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide),...
Symptomatic Decompensated Congestive Heart FailureCongestive Heart Failure in Acute Coronary SyndromeThe purpose of this study is to compare the hemodynamic (blood flow) and clinical effects of the study drug, Natrecor (nesiritide, a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure) to those of intravenous nitroglycerin or placebo, when added to the standard care therapy that is usually administered in the treatment of patients with worsening congestive heart failure.
A Study of Short-Term Outcomes and Economic Impact For Patients With Worsening Congestive Heart...
CardiomyopathiesHeart Failure3 moreThe purpose of this pilot study is to compare the clinical effects, safety profile, and economic impact of standard therapy plus Natrecor® (nesiritide, a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure) to standard therapy plus placebo in patients who present to the Emergency Department with worsening congestive heart failure (CHF) and are treated in the Emergency Department /Observation Unit.
A Safety Study Comparing Natrecor (Nesiritide) Versus Dobutamine Therapy for Worsening Congestive...
Heart FailureCongestiveThe purpose of this study is to compare the effects on heart rate and ventricular arrhythmias (irregular heart beats) of two doses of Natrecor® (a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure) versus dobutamine, during the first 24 hours of treatment of decompensated congestive heart failure (CHF).
EASYTRAK 4 Steerable LV Lead
Heart FailureThe primary objective of this clinical investigation is to evaluate the safety and effectiveness of the EASYTRAK 4 STEERABLE LV lead.
Peroral Levosimendan in Chronic Heart Failure
Chronic Heart FailureHeart DiseasesThe study will investigate the efficacy of oral levosimendan in patients with chronic New York Heart Association (NYHA) IIIb-IV heart failure (HF) using a composite end-point evaluating patient symptoms, morbidity and mortality. The patients are on treatment for at least 6 months.
Ultrafiltration Versus Intravenous (IV) Diuretics for Patients Hospitalized for Acute Decompensated...
Congestive Heart FailureThe purpose of this study is to compare patients who are suffering from heart failure and who are fluid overloaded to determine if ultrafiltration (UF) can remove more of the extra fluid as measured by weight loss while in the hospital and improve the patient's breathing.
Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function
Cardiovascular DiseasesHeart Diseases2 moreThe purpose of this study is to evaluate the effectiveness of aldosterone antagonist therapy in reducing cardiovascular mortality, aborted cardiac arrest, and heart failure hospitalization in patients who have heart failure with preserved systolic function.
A Study of the Safety and Efficacy of Follow-up Serial Infusions of Natrecor(Nesiritide) for the...
Heart FailureCongestiveThe purpose of this study is to evaluate the efficacy and safety of Nesiritide administered as serial infusions to heart failure (HF) patients in the outpatient setting.
Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH)...
Cardiovascular DiseasesHeart Diseases3 moreTo conduct a randomized, unblinded clinical trial comparing the left ventricular assist device (LVAD) with maximum medical management in patients with end-stage heart failure who were not candidates for heart transplantation.
Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
ArrhythmiaCardiovascular Diseases7 moreTo compare conventional treatment of congestive heart failure (CHF) with two experimental interventions: amiodarone and an implantable cardioverter-defibrillator (ICD).