Comparison of CRT-D and CRT-DX Systems (CRT-NEXT)
Heart FailureCardiac Resynchronization TherapyThe principal objective is to test non-inferiority of the CRT-DX system as compared to a conventional CRT-D system, in terms of the combined endpoint of mortality, hospitalizations due cardiovascular causes, any complication leading to loss of lead functionality, in the subset of patients without evidence of sinus dysfunction on optimal therapy.
Influenza Vaccine To Prevent Adverse Vascular Events (RCT-IVVE)
Heart FailureInfluenzaA multi-centre, randomized, placebo controlled, trial. Participants at high-risk for vascular events from the network of INTER- CHF will be randomized to inactivated influenza vaccine or placebo and followed prospectively over three influenza seasons. 5,000 participants will be enrolled prior to influenza season, randomized to either influenza vaccine or saline placebo, either of which they will receive annually for three years and then followed over each of the influenza seasons.
Three-dimensional Assessment of Intraventricular Dyssynchrony Using Fast Dobutamine Gated SPECT...
Heart FailureThe prognosis of patients with heart failure has improved due to recent breakthrough in medical treatment and cardiac resynchronization devices. However, there is no paraclinical parameter to assess response to cardiac resynchronization therapy (CRT). This is a major issue since about a third of implanted patients will not be improved by CRT. CZT SPECT allows to perform myocardial perfusion imaging in less than 4 minutes and is able to study myocardial perfusion, viability, left ventricular function, but also ventricular asynchrony. Using low-dose dobutamine gated SPECT and CZT camera, we aimed to assess left ventricular dyssynchrony in viable segments in patients with heart failure eligible for CRT.
Value of Renal Vascular Doppler Sonography in Management of Decompensated Heart Failure
Cardiorenal SyndromeAlthough the traditional determinant of renal dysfunction in heart failure was suggested as decreased cardiac output and renal hypo perfusion, recent studies have demonstrated the association of persistent systemic venous congestion and kidney dysfunction. Relief of the congestion has demonstrated to improve renal functions in decompensated heart failure. The current trial was set up to investigate the changes of renal venous impedance and renal arteriolar resistivity indices with diuretic therapy, in patients with congestive renal failure. The investigators asked whether measurement of renal venous impedance index or renal arteriolar resistivity index can guide the practice of diuretic therapy.
Role of Cardiac Computed Tomography in Optimising Response to Cardiac Resynchronisation Therapy...
Heart FailureThe purpose of this study is to determine if detailed scanning of the heart before biventricular device insertion will improve outcomes for heart failure patients.
Reducing Sedentary Time in Patients With Heart Failure
Heart FailureTo determine the change in sedentary time and number of steps/day for older patients with heart failure at risk for mobility disability who receive a program to decrease sedentary behavior versus a standard program to increase exercise.
Left Ventricular Dyssynchrony in Multipole Pacing
Heart Failure,CongestiveLeft ventricular dyssynchrony will be assessed by echocardiography using different programming of an implantable cardioverter defibrillator.
Pharmacodynamic Effects of Sacubitril/Valsartan on Natriuretic Peptides, Angiotensin and Neprilysin...
Heart FailureSystolicThe study measure multiple neurohormones in patients with heart failure being treated with Sacubitril/Valsartan in increasing doses over an 8 week period.
More Options Available With a Quadripolar LV Lead pRovidE In-clinic Solutions to CRT Challenges...
Postoperative Cardiac ComplicationHeart Failure3 moreThis investigation is designed with the hypothesis that using a quadripolar left ventricular lead results in less interventions when dealing with high pacing thresholds and Phrenic Nerve Stimulation (PNS), both at implant and during follow-up, compared to standard bipolar left ventricular leads.
The Impact of Exercise Training on Functional Capacity in Heart Failure
Heart Failure With Preserved Ejection FractionThe purpose of this study is to determine whether exercise training will improve functional capacity in patients with heart failure and preserved ejection fraction.