Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis...
Seizure in Participants With Tuberous Sclerosis ComplexSeizure in Participants With Dravet Syndrome1 moreThis study will be conducted to evaluate the safety, pharmacokinetics (PK), and efficacy of adjunctive GWP42003-P in participants < 2 years of age with tuberous sclerosis complex (TSC), Lennox-Gastaut syndrome (LGS), or Dravet syndrome (DS).
Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol)...
Lennox Gastaut SyndromeDravet Syndrome1 moreThis study will monitor for potential chronic liver injury and liver fibrosis, in participants treated with cannabidiol oral solution.
Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy...
Developmental and Epileptic EncephalopathyDravet Syndrome1 moreThe objective of this study is to assess the long-term safety, tolerability, and efficacy of adjunctive therapy of LP352 in subjects with developmental and epileptic encephalopathies who completed participation in Study LP352-201.
A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut...
Dravet Syndrome (DS)Lennox Gastaut Syndrome (LGS)The main aim of the study is to learn if soticlestat, when given as an add-on therapy, reduces the number of seizures in children and adults with Dravet Syndrome (DS) or Lennox-Gastaut Syndrome (LGS). Participants will receive their standard anti-seizure therapy, plus tablets of soticlestat. There will be scheduled visits and follow-up phone calls throughout the study.
EPX-100 (Clemizole Hydrochloride) as Add-on Therapy to Control Convulsive Seizures in Patients With...
Dravet SyndromeThe purpose of this study is to evaluate the safety and efficacy of EPX-100 as adjunctive therapy in children and adult participants with Dravet Syndrome.
A Study of Soticlestat as an Add-on Therapy in Children and Young Adults With Dravet Syndrome
Dravet Syndrome (DS)The main aim of the study is to learn if soticlestat, when given as an add-on therapy, reduces the number of convulsive seizures in children and young adults with DS. Participants will receive their standard antiseizure therapy, plus either a tablet of soticlestat or placebo for 16 weeks. A placebo looks just like soticlestat but will not have any medicine in it. Participants may continue treatment in an extension study, based on the extension study's entry criteria. Those that want to stop treatment will have a gradual dose reduction during 1 week and then be followed up for 2 weeks.
A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome
EpilepsiesMyoclonicThe primary purpose of the study is to demonstrate that lorcaserin has superior efficacy compared to placebo on percent change in frequency of convulsive seizures per 28 days in participants with Dravet syndrome.
An Open-Label Extension Study of STK-001 for Patients With Dravet Syndrome
Dravet SyndromeStoke Therapeutics is evaluating the long-term safety & tolerability of repeated doses of STK-001 in patients with Dravet syndrome who previously participated in studies of STK-001. Change in seizure frequency and overall clinical status, and quality of life will be measured as secondary endpoints in this open-label study.
A Study to Assess the Usability of the Embrace Seizure Detection Watch in Children and Young Adults...
Dravet SyndromeThis is a sub-study to ZX008-1503. Subjects will be fitted with an Embrace seizure detection watch and seizures detected by the watch will be compared to those entered into an electronic seizure diary.
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK
Myoclonus EpilepsiesProgressiveA randomized, double-blind, placebo-controlled, crossover study to assess the safety, tolerability, and pharmacokinetics of single doses of AUT00201 at 100 mg or matching placebo in patients with myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK).