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Active clinical trials for "Head and Neck Neoplasms"

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A Prospective Observational Study to Evaluate Acute Kidney Injury Biomarkers In Patients Receiving...

Head and Neck Cancer

The project is designed to test new biomarkers that are more sensitive than the current standard in detecting injury to the proximal kidney tubule and will establish better criteria for when kidney safety concerns may halt further testing of a drug in humans.

Unknown status20 enrollment criteria

Mucin Glycosylating Enzymes in Head and Neck Cancers

Glycosyltion Enzymes and Function Abnormalities

Head and neck squamous cell carcinoma(HNSCC) is the fourth common malignancy in Taiwan. It accounts for 5.8% of all cancers and causes 2,463 deaths per year. Aberrant glycosylation is the hallmark of most human cancers, including HNSCC, and affects many cellular properties. This study is aimed at exploring the role of mucin glycosylating enzymes in HNSCC.

Unknown status2 enrollment criteria

Acquisition of 3D Facial Geometry of Patients' Scheduled for Radiotherapy Treatment

Head and Neck Cancer

This study investigates the feasibility of using 3D-Printing to manufacture masks used to immobilize patients undergoing radiotherapy treatment for tumors affecting the head and neck.

Unknown status3 enrollment criteria

Serum Immunological Profiles in Head and Neck Cancer Patients Receiving Curative Radiotherapy

Head and Neck Cancers Patients

The purpose of the study is to investigate the clinical usefulness of serum levels of immunologic profiles including pro/anti-inflammatory interleukins, other detectable serum biomarkers including transforming growth factor b1 (TGFb1) or soluble major histocompatibility complex Class I chain-related peptide A (sMICA), and leukocyte subpopulations in head and neck cancers patients receiving curative radiotherapy, as prognostic biomarkers for disease recurrence and survival.

Unknown status2 enrollment criteria

Transoral Robotic Surgery for rECurrent Tumours of the Upper Aerodigestive Tract

Recurrent Head and Neck Cancer

transoral Robotic surgery for rECurrent tumours of the Upper aerodigestive Tract

Unknown status6 enrollment criteria

The SEA CHANGE Study: A Self Management Intervention for Head and Neck Cancer Survivors

Head and Neck Cancer

This study aims to test the feasibility of implementing the Self-Management after Cancer of the Head and Neck Group Intervention (SEA-CHANGE), designed to promote quality of life and participation in life activities and reduce distress in people who have completed primary treatment for head and neck cancer as compared to usual care.

Unknown status9 enrollment criteria

Cetuximab Therapeutic Drug Monitoring in Squamous Cell Carcinoma Head and Neck Cancer Patients:...

Head and Neck Cancer

Only about 30 percent of cancer patients have a clinical benefit upon cetuximab administration. Pilot studies in colorectal and head and neck cancer patients have suggested that cetuximab pharmacokinetics (PK), i.e. clearance values, could impact on clinical outcomes such as survival. Determining cetuximab plasma clearance requires sophisticated PK modeling using population approaches, thus making it difficult to implement in routine clinical practice. In addition, all the preliminary studies with cetuximab were based upon Elisa determination of cetuximab plasma levels, an analytical method that fails to meet the requirements of daily practice in laboratories performing therapeutic drug monitoring. This pilot study aimed at evaluating the mass spec method analytical performance as part of a " real life " study, evaluating the inter-patient variability of exposure levels in head and neck cancer patients, and establishing a putative link between those exposure levels and clinical outcome. Results from 25 patients fully confirmed the analytical performance of the mass spec method (e.g., lack of matrix effect, acceptable sensitivity to monitor trough levels, lack of impact of sampling processing or freezing/thawing cycles). In addition, a large inter-individual variability (Superior at 50 percent) was observed, both in the peak concentrations (Cmax) and in trough levels (Cmin). Most interestingly, despite the limited number of patients enrolled, a statistically significant association was shown between exposure levels (i.e. calculated AUC) and clinical outcome (DCR). This difference was even more significant on Cmin, thus suggesting that simple trough levels monitoring could help to predict efficacy. Further analysis on survival showed that although not statistically significant, a trend towards longer both progression-free survival and overall survival was observed in the subgroup of patients with higher trough levels. In particular, 3-year survival was 29 percent and 0 percent in the subgroups with high and low trough concentrations, respectively (unpublished data). Beyond tumoral factors, these preliminary data suggest that cetuximab Cmin levels could be a predictive marker of therapeutic efficacy and that simple therapeutic drug monitoring could help to forecast clinical outcome or enable dosage adaptation.

Unknown status8 enrollment criteria

RGD-K5 in Head and Neck Cancer Patients

Head and Neck Neoplasms

Primary endpoint(s): To determine the relationship between the drug distribution and angiogenesis in head and neck cancer patients. Secondary endpoint(s): To expand the safety database of [F-18]RGD-K5 and to correlate the parameters from the image study to clinical treatment response and prognosis.

Unknown status8 enrollment criteria

Total Body Composition in Detection of Nutrition Depletion in Head and Neck Patients

Head and Neck NeoplasmsDual-Energy X-Ray Absorptiometry1 more

The purpose of this study is to define the role of total body composition in the guidance of nutritional support and treatment monitoring in head and neck patients. Furthermore, the second aim of this study is to compare the clinical performance of dual energy X-ray absorptiometry as compared to CT in evaluating total body composition of patients.

Unknown status21 enrollment criteria

ALDH2 Mutation in Taiwanese Head and Neck Cancer

DermatitisMucositis

The purpose of this study is to evaluate the effect of ALDH2 mutation in radiation associating dermatitis or mucositis in head and neck cancer patients who accept chemoradiation therapy

Unknown status10 enrollment criteria
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