search

Active clinical trials for "Neoplasms, Germ Cell and Embryonal"

Results 51-60 of 284

Molecular Epidemiology of Pediatric Germ Cell Tumors

Germ Cell TumorGerminoma7 more

A Non-Therapeutic Study that aims to establish a cohort of GCT survivors to understand short term and long-term adverse effects of treatment and to conduct molecular analyses to improve risk stratification.

Recruiting7 enrollment criteria

MAGESTIC Trial: MiRNA in Detecting Active Germ Cell Tumors in Early Suspected and MetastaTIC Disease...

Malignant Testicular Germ Cell Tumor

This study evaluates the accuracy of blood-based biomarker testing to predict the presence of active testicular cancer.

Recruiting18 enrollment criteria

Embryonal Tumors of Infancy & Childhood: South Egypt Cancer Institute Experience

NeoplasmsEmbryonal1 more

The aim of this study is to investigate demographic & disease characteristics of pediatric cancer patients diagnosed with one of embryonal tumors to identify the prevalence, the spectrum of these disease entities & treatment outcomes in these patients.

Recruiting3 enrollment criteria

Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors

Adenocarcinoma of the BladderSquamous Cell Carcinoma of the Bladder1 more

Background: Many cancers of the testicles and urinary tract are rare diseases; these are diseases that affect less than 200,000 people in the United States. It can be hard to study treatments for these diseases. One combination of drugs-enfortumab vedotin (EV) and pembrolizumab-has already been approved to treat some urinary cancers. Researchers want to see if they can help people with other types of testicle and urinary cancers. Objective: To test EV, with or without pembrolizumab, in patients with rarer cancers of the testicles or urinary tract. Eligibility: People aged 18 and older with rarer cancers of the testicles or urinary tract. Design: Participants will be screened. They will have a physical exam with blood and urine tests. Their ability to perform normal daily activities will be tested. They will have exams of their skin and eyes. They will have imaging scans. A biopsy may be needed: A sample of tissue will be removed from the tumor. The study drugs are both given through a tube attached to a needle inserted into a vein in the arm. Some participants will receive treatments 3 times during 28-week cycles; others will receive treatments 2 times during 21-day cycles. All participants may continue to receive treatments for up to 5 years. Imaging scans and other tests will be repeated. Participants who stop taking the drugs will have follow-up visits every 3 to 4 weeks until the disease gets worse. They will have imaging scans and blood tests. After that, follow-up visits will continue by phone every 3 months for up to 5 years after study therapy is finished.

Not yet recruiting38 enrollment criteria

Follow-up After Surgery for Testicular Cancer

Testicular CancerTesticular Germ Cell Tumor1 more

The currently developed implementation study aims to evaluate if a patient-led home-based follow-up approach is successful, improves quality of life, reduces anxiety and lessens fear of cancer recurrence during the years after treatment of certain types of testicular cancer.

Recruiting19 enrollment criteria

Nab-PTX, Ifosfamide and Cisplatin in the Treatment of Pediatric Extracranial Germ Cell Tumor.

Extracranial Germ Cell TumorPediatric

The purpose is to evaluate the effectiveness and safety of albumin-bound paclitaxel (nab-PTX), ifosfamide and cisplatin in the treatment of children patients with advanced, recurrent or refractory extracranial germ cell tumor.

Not yet recruiting29 enrollment criteria

Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

Breast CancerNOS21 more

The purpose of this study is to evaluate feasibility and acceptability of completing PROs among AYAs randomized to Choice PRO vs Fixed PRO.

Recruiting5 enrollment criteria

Computer Aided Diagnostic Tool on Computed Tomography Images for Diagnosis of Retroperitoneal Tumor...

Wilms' TumorNeuroblastoma4 more

The aim of this study was to evaluate the diagnostic efficacy of computer aided diagnostic tool for retroperitoneal tumor using machine learning and deep learning techniques on computed tomography images in children.

Recruiting6 enrollment criteria

Morbidity, Long-term Side Effects and Quality of Life in Germ-cell Tumor Long Survivors Treated...

Germ Cell Tumor

Intensified chemotherapy is an effective treatment in 30-70% of patients with refractory germ cell tumor. Since most cases are diagnosed before the age of 40, survivors can expect to live another 30 to 50 years after being successfully treated. Long-term side effects and physical and emotional consequences can therefore have a significant impact on daily life. To date, no data of this type is available in France. This study will help clinicians better understand the long-term consequences for relapsed patients receiving high-dose chemotherapy.

Recruiting11 enrollment criteria

Toxicity Attributed to Genetic Polymorphisms in Testicular Germ Cell Tumor Survivors

Germ Cell Cancer

The purpose of this study is to identify genetic variations in survivors of testicular cancer and connect these variations to differences in risks of late effects.

Recruiting5 enrollment criteria
1...567...29

Need Help? Contact our team!


We'll reach out to this number within 24 hrs