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Active clinical trials for "Lung Neoplasms"

Results 1091-1100 of 6521

A Trial of Integrating SBRT With Targeted Therapy in Stage IV Oncogene-driven NSCLC

Non-small Cell Lung Cancer MetastaticTargetable Oncogenes (EGFR2 more

This research study is studying a type of radiation therapy called Stereotactic Body Radiation Therapy (SBRT) as a possible treatment for stage IV non-small cell lung cancer (NSCLC) that has a mutated epidermal growth factor receptor (EGFR) or or displaced anaplastic lymphoma receptor tyrosine kinase (ALK) or ROS proto-oncogene 1 (ROS1) gene (= oncogene-driven NSCLC) and for which the subject has been receiving treatment with a targeted biological agent such as erlotinib, crizotinib, or other drugs.

Active21 enrollment criteria

Phase II Study of Pembrolizumab After Curative Intent Treatment for Oligometastatic Non-Small Cell...

Oligometastatic Non-small Cell Lung Cancer (NSCLC)

The main purpose of this study is to see how well the experimental drug pembrolizumab (MK-3475) works in people with oligometastatic NSCLC who have already had treatment for their disease. All patients will receive 200 mg of pembrolizumab intravenously on Day 1 of each 21-day cycle. Patients will receive the study drug for up to 8 cycles, and then if their disease is doing well and the study doctor thinks they will benefit patients may receive pembrolizumab for up to 8 more cycles.

Active42 enrollment criteria

Image-Guided Hypofractionated Radiation Therapy With Stereotactic Body Radiation Therapy Boost and...

Adenocarcinoma of the LungAdenosquamous Cell Lung Cancer7 more

This clinical trial studies image-guided hypofractionated radiation therapy (RT) when given together with hypofractionated RT boost and combination chemotherapy in treating patients with stage II-III non-small cell lung cancer (NSCLC) that cannot be removed by surgery. RT uses high energy x-rays to kill tumor cells. Hypofractionated RT may be able to send x-rays directly to the tumor and cause less damage to normal tissue. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving RT together with combination chemotherapy may kill more tumor cells and allow doctors to save the part of the body where the cancer started

Active11 enrollment criteria

Surgery and/or Radiation Therapy or Standard Therapy and/or Clinical Observation in Treating Patients...

Recurrent Lung Non-Small Cell CarcinomaStage IV Non-Small Cell Lung Cancer AJCC v7

This randomized phase II trial studies how well surgery and/or radiation therapy or standard therapy and/or clinical observation works in treating patients with previously treated stage IV non-small cell lung cancer. Radiation therapy uses high energy x-rays to kill tumor cells. Giving surgery and/or radiation therapy may be more effective than standard therapy and/or clinical observation in patients with previously treated non-small cell lung cancer.

Active24 enrollment criteria

LDK378 Versus Chemotherapy in Previously Untreated Patients With ALK Rearranged Non-small Cell Lung...

Non-Small Cell Lung Cancer

The primary purpose of the study was to compare the antitumor activity of LDK378 versus reference chemotherapy. Patients in the chemotherapy arm were allowed to cross-over to LDK378 after confirmed progressive disease (PD).

Active6 enrollment criteria

Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant...

Unresectable Pleural or Peritoneal Malignant Mesothelioma

This is a Phase 2b, randomized, double-blind, parallel-group study. Subjects with unresectable pleural or peritoneal malignant mesothelioma will be randomized in a 2:1 ratio to receive either tremelimumab or placebo. Approximately 564 subjects will be enrolled at study centers in multiple countries. The study consists of a screening period, a treatment period, a 90-day follow-up period for safety, and a long-term survival follow-up period.

Active31 enrollment criteria

Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd...

Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV

The purpose of this study is to assess the efficacy of selumetinib in combination with docetaxel (75mg/m2) vs placebo in combination with docetaxel (75mg/m2) in patients with locally advance or metastatic NSCLCs that harbor mutations of KRAS. This study will also assess the PK, safety, patient reported outcomes (PRO) and tolerability profile of the selumetinib/docetaxel combination, compared to placebo in combination with docetaxel

Active11 enrollment criteria

PALBOCICLIB + PD-0325901 for NSCLC & Solid Tumors

KRAS Mutant Non-Small Cell Lung CancerSolid Tumors

This research study is evaluating the experimental drug palbociclib in combination with another experimental drug PD-0325901 as a possible treatment for cancers with KRAS mutations, particularly for those which started in the lung.

Active25 enrollment criteria

Lung Cancer Exercise Training Study

Lung Cancer

The purpose of the study is look at the effects of different types of exercise training with a stretching group and its effect on lung cancer patients. Subjects will take part in a 16 week training intervention that can consist of aerobic, resistance, aerobic & resistance, or a control group. Pre and Post testing will include stress tests, echos, blood, and urine samples.

Active38 enrollment criteria

Effect of Pulmonary Rehabilitation on Surgical Outcomes in the Cancer Setting

Lung Cancer

The goal of this clinical research study is to see if pulmonary rehabilitation can improve patients' lung function, which would increase their chances of becoming eligible for surgery. The health of pulmonary rehabilitation participants after surgery will also be examined.

Active8 enrollment criteria
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