PET/CT Guided Robotic Arm-assisted Pain Palliation in Chronic Nociceptive Low Backache
Chronic Low-back PainNociceptive PainA study to investigate the role of F-18 sodium fluoride in localizing the pain generator in participants with chronic nociceptive musculoskeletal low back ache and to study the use of PET/CT guided robotic arm assisted injection for targeted injection of a combination of corticosteroid and local anesthetic for pain palliation.
The Impact of Esmolol Administration on Postoperative Recovery
PainAcute8 moreThe aim of this study will be to investigate the effect of a continuous infusion of low dose esmolol on intraoperative and postoperative opioid consumption, as well as on postoperative recovery and chronic pain
Opioid Sparing Anesthesia in Cervical Spine Surgery
PainPostoperative11 moreThe aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of lidocaine and ketamine in the same syringe versus remifentanyl analgesia in cervical spine surgery.
Opioid Sparing Anesthesia in Lumbar Spine Surgery
PainPostoperative12 moreThe aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus remifentanil analgesia in lumbar spine surgery
A Study of the Effects of Intravenous Magnesium Sulphate on Anaesthesia and Analgesia in Elective...
PainPostoperative6 moreThe aim of this double-blind randomized study will be to evaluate the effect an intravenous infusion of magnesium has on recovery outcomes after elective laparoscopic cholecystectomy
Opioid-free Anesthesia in Thyroidectomies
PainPost Operative15 moreThe aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective thyroidectomies. Recovery parameters and nociception levels throughout the operation will be evaluated
NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane
Nociceptive PainAnesthesiaThe purpose of this prospective randomized controlled study is to compare the analgesic properties of propofol and sevoflurane using variation of the NOL index and standard monitoring (Heart Rate and Mean Arterial Blood Pressure) when patients under general anaesthesia with either agents are subjected to a standardized painful stimulus (a tetanic stimulation over the ulnar nerve at 70 mA, 100 Hz for 30 seconds).
Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine
PainPostoperative15 moreThe aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective laparoscopic gynecological surgery
Correlation Between NOL Index After Stimulus and Post-operative Opioid, Pain, Pre-operative Phenotype...
PainPostoperative3 moreThis study evaluates the correlation between NoL index response to standardized stimulus under general anesthesia and the post-operative pain, assessed by opioid consumption and numerical pain scores after video-assisted thoracoscopy (VATS).
PET/MRI in the Diagnosis of Chronic Pain
Neuropathic PainNociceptive Pain5 moreSeveral studies have implicated involvement of sigma-1 receptors (SR1s) in the generation of chronic pain, while others are investigating anti SR1 drugs for treatment of chronic pain. Using [18F]-FTC-146 and positron emission tomography/magnetic resonance imaging (PET/MRI), the investigators hope to identify the source of pain generation in patients with chronic pain. The purpose of this study is to compare the uptake of [18F]FTC-146 in healthy volunteers to that of individuals suffering from chronic pain.