Non-invasive Biomarkers of Metabolic Liver Disease (NIMBLE) Study 1.2
Nonalcoholic Fatty LiverThis study is a prospective, observational, single-center, short-term cross-sectional study to assess the repeatability and reproducibility of a set of specified MRI quantitative biomarkers.
Ultrasound Quantification of Liver Fat
Non-Alcoholic Fatty Liver DiseaseThe investigators plan a prospective study designed to evaluate the accuracy of a new ultrasound method for quantification of liver fat content.
The Role of Immune Semaphorins in NAFLD
Non-Alcoholic Fatty Liver DiseaseImmune Response3 moreTo goal is to identify semaphorins that are associated with NAFLD and to investigate their relationship with variable degrees of steatosis and fibrosis.
Barriers to MASLD Management in Europe: Findings From a Multidisciplinary HCP-survey
Non-alcoholic Steatohepatitis (MASH)Non-alcoholic Fatty Liver Disease (MASLD)The purpose of this study is to better understand the main barriers to earlier diagnosis and better management of MASLD/MASH patients and to understand the key barriers to adoption of guidelines. This study is a cross-sectional design, conducted across 5 countries in Europe- France, Germany, Spain, United Kingdom (UK), Italy. Study participants, Hepatologists and other metabolically focused healthcare providers (HCPs), will be recruited to complete a 15 minute self-administered online survey.
Assessing Kids for Liver Inflammation and Fibrosis Using Non-invasive MRI
Non-alcoholic SteatohepatitisLiver Diseases3 moreThis is a prospective observational study which will recruit up to 100 paediatric participants over a period of 30 months to determine whether MRI is as accurate at detecting, distinguishing, and monitoring liver disease as current standard of care techniques such as liver biopsy and fibroscan.
Dietary Determinants in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)
Dietary IntakeNAFLDPatients with NAFLD and matched controls will be asked about their demographic status, and their previous year dietary intakes using a validated FFQ.
Seum Bile Acid Profile in Type 2 Diabetes and Association Between Bile Cid Profile and Adipokine...
Type 2 DiabetesPrediabetes2 more"The goal of this work is to critically test the hypothesis that there exists a different profile of bile acids (BAs) in patient with type 2 diabetes mellitus (T2DM) compared with normal controls. Through confirmation of different profile of BAs in T2DM, investigator will suggest modulation of specific bile acids as a new possible treatment target in patients with T2DM. Investigator also expect the specific BAs signature will be used to screen T2DM before hyperglycemia. In addition, investigator will evaluate the association between each BA species and serum total glucagon like peptide-1 (GLP-1) or fibroblast growth factor-19 (FGF-19) concentrations to determine if the specific BAs profile is related with total GLP-1 or FGF-19 concentration in serum. Investigatr also evaluates the correlation between each BA species and metabolic profiles and oxidative stress marker to find possible roles of each BA component in glucose metabolism.
Study of the Association of Nonalcoholic Fatty Liver Disease With Colorectal Malignant Neoplasm...
Colorectal NeoplasmsNonalcoholic Fatty Liver DiseaseThe aim of this sudy is to investigate the prevalence of colorectal cancer (CRC) in patients with nonalcoholic fatty liver disease (NAFLD) and evaluate whether NAFLD is a risk factor for CRC.
A Case Control Study Evaluating the Prevalence of Non-Alcoholic Fatty Liver Disease Among Patients...
PsoriasisNonalcoholic Fatty Liver DiseaseMain objectives 1. Establish the association of psoriasis and the presence of NAFLD in the patients with psoriasis attending dermatologic clinic center. Secondary objective Evaluate for the presence of other components metabolic syndrome in this group of patients including hypercholesterolemia, hypertension, obesity, and insulin resistance Determine if there is an association between the extent and severity of psoriasis and the presence of NAFLD. Identify an association between BMI and presence of NAFLD in people with psoriasis and use it as a predictive index for primary screening of NAFLD in psoriatic patients.
Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors...
DyslipidemiaDiabetes6 moreFructose-containing sugars have been implicated in the epidemics of obesity, diabetes and related cardiometabolic disorders. This view is supported by lower quality evidence from ecological observations, animal models, and select human trials. Higher level evidence from controlled trials and prospective cohort studies have been inconclusive. Whether sugars contribute to cardiometabolic complications independent of their calories remains unclear. To address the uncertainties, the investigators propose to conduct a series of systematic reviews and meta-analyses of the totality of the evidence from controlled trials to distinguish the contribution of fructose-containing sugars from that of energy in the development of markers of cardiometabolic risk. The findings generated by this proposed knowledge synthesis will help improve the health of consumers through informing evidence-based guidelines and improving health outcomes by educating healthcare providers and patients, stimulating industry innovation, and guiding future research design.