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Active clinical trials for "Carcinoma, Non-Small-Cell Lung"

Results 5081-5090 of 5094

Acquired Resistant Mechanism of the First-generation EGFR TKIs

Non-small Cell Lung CancerAquired Resistance1 more

Patients with advanced non-small-cell lung cancer (NSCLC) harboring sensitive epithelial growth factor receptor (EGFR) mutations invariably develop acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). Identification of actionable genetic mutations can be helpful for guiding the subsequent treatment. This study aimed to analyze the genetic profile of NSCLC harboring acquired resistance to the first-generation EGFR TKIs using next generation sequencing (NGS).

Unknown status7 enrollment criteria

The Role of Microbiota on the Development of Lung Cancer

NSCLCStage I6 more

Relationship between human microbiota and epidemiology of lung cancer

Unknown status2 enrollment criteria

Circulating Tumor DNA Detection in Surveillance of Surgical Lung Cancer Patients

CarcinomaNon-small-cell Lung Cancer1 more

Conduct a prospective study to confirm blood and urine ctDNA detection value in non-small-cell lung cancer patients.

Unknown status13 enrollment criteria

The Value Of Circulating Tumor Cells In Patient With NSCLC In Postoperative Recurrence Monitoring...

Non-small-cell Lung Carcinoma

The purpose of this study is to assess the value of circulating tumor cells (CTC)for non-small cell lung cancer in the postoperative recurrence monitoring by comparing the CTCs, CT and tumor markers at different time points.The time of CTC and carcinoembryonic antigen(CEA) detection is baseline, 2~7 days, 3 months, 6 months, 12 months, 24 months, 36 months after the surgery. And the time of CT detection is 6 months, 12 months, 24 months, 36 months after the surgery.

Unknown status10 enrollment criteria

Gene Mutations in Non-Small Cell Lung Cancer Cells

CarcinomaNon-Small-Cell Lung

To compare the frequency of individual genetic abnormality between tumor cells and blood specimens.

Unknown status8 enrollment criteria

Establishment and Characterization of Patient-Derived Non-Small Cell Lung Cancer Xenografts and...

Non Small Cell Lung Cancer

Xenografts and cell cultures provide sufficient material for analyses at the protein, RNA and DNA level. Patient derived NSCLC xenografts and cell lines are available but none however are Asian in origin. Given the emerging evidence to suggest inter-ethnic differences in NSCLC biology, new models of preclinical drug evaluation should be designed and validated using Asian tumors. Furthermore, such models will allow studies of biological mechanisms of sensitivity and/or resistance and also the study of dynamic regulations under standardized conditions in the Asian context.

Unknown status3 enrollment criteria

Prognostic Role of Primary Non Small Cell Lung Carcinoma Standardized F18-FDG Uptake Values (SUV...

Non Small Cell Lung Carcinoma

The primary aim of this non interventional study is to assess the independent prognostic role on overall survival of primary tumour 18F-FDG uptake value (SUVmax) measured on 18fluorodeoxyglucose positron emission tomography (18F-FDG-PET) in patients with non-metastatic non-small cell lung cancers treated with curative intent, taking into account the other conventional prognostic factors (performance status, age, sex, disease stage).

Unknown status14 enrollment criteria

Mutations in the Epidermal Growth Factor Receptor(EGFR) Gene in Non-Small Cell Lung Carcinoma (NSCLC)...

Non-Small Cell Lung Cancer

Recently it has been suggested that specific mutations in the EGFR gene in lung cancer patients is associated with response to a novel drug targeting the EGF system. Recent research also indicates that there is a possible association to the degree of aggressiveness of the disease. The importance of these mutations is controversial, because the data are based on small studies with highly selected patients. In this project the investigators want to study the types and frequencies of EGFR mutations in both untreated and treated patients in a systematic manner and relate this to survival. The thorough registration of patient data in DK enables us to create a strong The investigators expect this knowledge to be of greatest importance for future rational use of drugs targeting the EGF receptors.

Unknown status2 enrollment criteria

CT-based Radiomic Signature Can Identify Adenocarcinoma Lung Tumor Histology

Nonsmall Cell Lung Cancer

Lung cancer remains the leading cause of cancer related mortality worldwide, with more than 1.5 million related deaths annually. Lung cancer is divided into two main groups: Small Cell Lung Carcinoma (SCLC) and Non-Small Cell Lung Carcinoma (NSCLC), with prevalence of ~20% and 80% respectively. NSCLC is further subdivided into adenocarcinoma (the most common), squamous cell carcinoma (SCC), and large cell carcinoma. Furthermore, each subtype is likely to have specific mutations, which could be targeted for treatment. Medical imaging and radiomics feature extraction represent a candidate alternative to conventional tissue biopsy, a theory that is investigated in this study.

Unknown status3 enrollment criteria

A Study to Explore Treatment Regimens and Clinical Outcomes of the NSCLC Patients With Different...

Non-small Cell Lung Cancer

A single-center, non-interventional prospective observational study in the NSCLC patients with different driver genes

Unknown status4 enrollment criteria
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