search

Active clinical trials for "Onychomycosis"

Results 101-110 of 141

Alpha-bisabolol for Onychomycosis Treatment

Onychomycosis

Clinical, interventional, longitudinal study with random sampling. 60 patients will be divided into three groups, group A: control group, drug recommended by the Brazilian Society of Dermatology, group B: alpha bisabolol-based product associated with low-level laser therapy, and group C: alpha bisabolol based product. The topical application will be performed twice a day, while the laser application and photographs of the lesions, every 15 days. Areas of the lesions will be compared.

Completed6 enrollment criteria

Early Feasibility Study to Evaluate the Efficacy of the RenewalNail™ Plasma Treatment System in...

Onychomycosis of ToenailOnychomycosis

A study to determine if a three-treatment protocol with the RenewalNail™ plasma treatment system over a week will result in mycological cure and/or clear nail growth on the treated hallux toe.

Completed25 enrollment criteria

Bioequivalency Study of Terbinafine Tablets Under Fed Conditions

Onychomycosis

The objective of this study was the bioequivalence of a Roxane Laboratories' terbinafine tablets, 250 mg, to Lamisil® Tablets, 250 mg (Novartis Pharmaceutical Corporation.) under fed conditions using a single-dose, randomized, 2-treatment, 2-period, 2-sequence crossover design.

Completed4 enrollment criteria

Effectiveness of Podiatry Care on Onychomycosis (EPOCAON)

Onychomycosis

Onychomycosis occurs in more than 50% of all pathologies unguinal, affecting the health and quality of life of the patient. Although the investigators have a wide therapeutic arsenal, there is still a disparity when carrying out an effective processing. Hypothesis/Objectives: To analyze if the use of the podiatric technique of aggressive unguinal abrasion with micrometer sports, in combination with topical treatment with amorolfin 5% in hairspray, significantly increases the effectiveness clinically as well as mycology. The investigators will analyze the relationship between this intervention and the quality perception of life related to the health of the nails and the foot. The investigators will Use results for next validation study in Spanish of the questionnaire NailQoL, as well as validation and reliability of the index SCIO and cost study-effectiveness of the processing. Method: The investigators will design a randomized control trial. The town will be recruited, informed prior consent will be obtained from patients of 5 Spanish centers of chiropody, with sample size of 313 patients. There will be a screening of 4 weeks to select patients with onychomycosis infections (clinic and mycology both positives); later the patients will be distributed randomly in 2 groups: GROUP AM+AU: Will be administered aggressive unguinal abrasion, weeks 0 (baseline), 12 and 24, followed by standard treatment of amorolfin 5%, two weekly applications during 36 weeks. GROUP AM: Will be administered exclusively standard treatment of amorolfin 5%, according to common format. The duration will be 48 weeks.

Withdrawn11 enrollment criteria

Study to Evaluate the Efficacy and Safety of P-3058 Nail Solution in the Treatment of Onychomycosis...

Onychomycosis of Toenail

The aim of this phase III study is to establish the efficacy and safety of P-3058 (terbinafine 10% nail solution) topically administered once weekly in patients with onychomycosis in comparison to the Vehicle in a double-blind fashion. The overall treatment period will be of 48 weeks.

Withdrawn30 enrollment criteria

A Study to See if Low Level Laser Light Can Help to Treat Toenail Fungus

Onychomycosis of Toenail

The purpose of this study is to determine whether low level laser therapy (LLLT) using the Erchonia LunulaLaser device is effective in clearing toenails with onychomycosis.

Withdrawn33 enrollment criteria

TDT 067 Open Label Multi-Dose Onychomycosis Study

Onychomycosis

The aim of this study is to establish a clinical bridge to Lamisil® tablets by conducting a clinical pharmacokinetic (PK) study comparing the systemic exposure of a Lamisil® tablet with that of with TDT 067 under maximal use conditions. Under maximal use conditions in onychomycotic subjects, the aim is to confirm that there are significantly lower plasma levels of terbinafine and its major metabolites after a topical administration of TDT 067 for 28 days in comparison with a single oral 250 mg Lamisil® tablet.

Completed27 enrollment criteria

Single-blind Evaluation of Device to Nail Micro-drilling in Onychomycosis

Onychomycosis

Based on manufacturer testing, no major difference in drilling condition is expected in this study compared to the drilling conditions previously established. However clinical testing is needed to establish optimal drilling conditions to be used for further development in both unaffected and affected parts of the nail. The aim of this study is to determine the optimal drilling condition that could be used in future studies of this device in combination with topical treatment for onychomycosis.

Completed17 enrollment criteria

An Open,Single-centre Pilot Study of Efficacy and Safety of Topical MOB015B in the Treatment of...

Distal Subungual Onychomycosis

Assess efficacy and safety of topical MOB015B, applied daily during 48 weeks, in adults with fungal nail infection.

Completed21 enrollment criteria

A Study of the Effects of Increasing Doses of a Drug for the Treatment of Nail Fungus

Onychomycosis

The purpose of this study is to determine an upper dose of albaconzole to be administered in a Thorough QTc study.

Completed27 enrollment criteria
1...101112...15

Need Help? Contact our team!


We'll reach out to this number within 24 hrs