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Active clinical trials for "Opioid-Related Disorders"

Results 61-70 of 1134

Buprenorphine Treatment Engagement and Overdose Prevention

Opioid-use Disorder

Office-based buprenorphine could be expanded to treat many of the opioid users who are not in treatment and who are at great risk for opioid overdose, but effective approaches are needed to help individuals with opioid use disorder initiate and remain in office-based buprenorphine treatment. Investigators propose to develop and pilot test a novel intervention that will combine video-based directly observed therapy and incentives to promote buprenorphine treatment engagement and adherence in out-of-treatment opioid users.

Recruiting3 enrollment criteria

Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy...

Opioid Use Disorder (OUD)

This is a two phase study investigating combinations of pharmacological and behavioral interventions to optimize the treatment of Opioid Use Disorder (OUD). The Retention Phase will assess strategies for improving retention on buprenorphine (BUP) and extended-release injectable naltrexone (XR-NTX). The Discontinuation Phase will assess which approaches are most likely to lead to long-term success (absence of relapse), and what characteristics of participants distinguish those who can safely discontinue Medications for Opioid Use Disorder (MOUD) from those who remain at risk of relapse and should not discontinue.

Recruiting42 enrollment criteria

Neuroimaging and CBD for Opiod Use Disorder

Heroin AbuseOpioid Use Disorder2 more

The investigators propose an imaging study to investigate the neurobiological effects of CBD (vs placebo) in participants with opioid use disorder who are maintained on methadone. The purpose of the study is to determine the neural circuits and transmitters associated with the effects of CBD on to reduce craving and anxiety. The neuroimaging will be conducted in participants immediately following their first administration of CBD (800mg or placebo) and one week after the last administration (3 daily doses). This CBD administration protocol was shown in previous studies by the investigators to reduce craving and anxiety in abstinent heroin users.

Recruiting19 enrollment criteria

Culturally Centering Medications for Opioid Use Disorder With American Indian and Alaska Native...

Opioid-use Disorder

This is a formative research study to test a culturally-centered, program-level implementation intervention to increase the use of medications for opioid use disorder in four healthcare and addiction specialty treatment sites serving American Indian and Alaska Native communities.

Recruiting8 enrollment criteria

Pilot Study of reSET-O to Treatment-as-usual in Acute Care Settings

Opioid-use Disorder

This randomized controlled pilot study will evaluate feasibility, acceptability, and potential efficacy of an app, reSET-O, for patients being started on buprenorphine in acute care settings.

Recruiting6 enrollment criteria

Optimization of NIBS for Treatment of Addiction

Opioid-use DisorderChronic Pain

The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug use and improved psychosocial assessments with active stimulation, when compared to sham stimulation.

Recruiting20 enrollment criteria

Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid...

Sleep DisorderRestless Legs Syndrome2 more

The investigators propose to test the use of pramipexole in patients being treated for Opioid Use Disorder to test its ability to reduce symptoms of both Restless Legs Syndrome and protracted opioid withdrawal and thereby promote initiation, engagement, and retention in treatment.

Recruiting19 enrollment criteria

Coordinating Opioid Use Treatment Through Medical Management With Infection Treatment (Project COMMIT)...

Opioid-use Disorder

This study seeks to test a new model of care (ID/LAB) in which opioid use disorder (OUD) is managed by infectious disease (ID) specialists and hospitalists concurrent with management of the OUD-related infections, using long-acting injectable buprenorphine (LAB), followed by referral as soon as possible after hospital discharge to community resources for long term treatment of OUD.

Recruiting10 enrollment criteria

Long-acting Buprenorphine vs. Naltrexone Opioid Treatments in CJS-involved Adults

Opioid-use Disorder

This study seeks to compare the effectiveness of two medications used to treat opioid use disorder, extended-release buprenorphine (XR-B) vs. extended-release naltrexone (XR-NTX), among adults currently incarcerated in U.S. jails and prisons at 5 distinct trial sites. This open-label, non-inferiority, head-to-head study design will offer providers, correctional and public health authorities, payers and policy makers' timely and relevant data to assess the effectiveness of XR-B (and XR-NTX) as potentially useful re-entry and relapse prevention treatment options. It is hypothesized that XR-B is non-inferior to XR-NTX when comparing retention-in-study-medication treatment options.

Recruiting16 enrollment criteria

Cognitive-Behavioral Therapy for Opioid Use Disorder: A Manualized Pilot Study

Opioid Use Disorder

The goal of this pilot clinical trial is to test the feasibility of a 12-week manualized cognitive-behavioral therapy treatment for opioid use disorder in reducing or stopping illicit opioid use in a community setting. Participants will complete 12 weeks of therapy with a behavioral health counselor and will complete assessments at baseline and 12 weeks. Other outcomes include changes in mood and perceptions of recovery-related support after 12 weeks of therapy.

Recruiting7 enrollment criteria
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