Evaluation of Lofexidine for Treatment of Opiate Withdrawal - 10
Opioid-Related DisordersThe purpose of this study is to assess the safety of lofexidine in the treatment of opiate-dependent individuals.
Evaluation of Lofexidine for Treatment of Opioid Withdrawal - 3
Opioid-Related DisordersSubstance-Related DisordersThe purpose of this study is to determine the safety of lofexidine in the treatment of opiate withdrawal. Preliminary data will also be obtained to assess the ability of lofexidine to alleviate opiate withdrawal signs and symptoms.
Effects of Buprenorphine and Naloxone in Opiate Addicts - 4
Opioid-Related DisordersSubstance-Related DisordersThe purpose of this study is to evaluate the behavioral and physiological effects of buprenorphine and naloxone, both alone and in combination.
Alternate-Day Buprenorphine Administration. Phase VI - 7
Opioid-Related DisordersThe purpose of this study is to determine if four times a subject's daily maintenance dose will hold for 96 hours without changes in agonist and antagonist effects.
Alternate-Day Buprenorphine Administration. Phase VII - 8
Opioid-Related DisordersThe purpose of this study is to determine if four times a subjects daily maintenance dose will hold for 96 hours without changes in agonist and antagonist effects under open dosing conditions.
Rapid Opiate Detoxification and Naltrexone Induction Using Buprenorphine - 2
Opioid-Related DisordersThe purpose of this study is to develop a clinical protocol to detoxify patients from opiates to naltrexone using buprenorphine and to develop pilot data for a grant application for a controlled study of the efficacy of the new clinical protocol for outpatients.
Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3
Cocaine-Related DisordersOpioid-Related DisordersThe purpose of this study is to evaluate dextroamphetamine sulfate (sustained release) as an adjunct in concurrent cocaine and opiate dependent patients.
Combining Behavioral Treatment With Agonist Maintenance - 1
Cocaine-Related DisordersOpioid-Related Disorders1 moreThe purpose of this study is to evaluate whether the community reinforcement approach (CRA) plus contingency management (CM) is more effective overall than CRA only in reducing illicit opioid and cocaine use during agonist maintenance treatment and at 3 and 6 month follow-up after completion of study protocol, and to compare the efficacy of maintenance on buprenorphine to methadone when maintenance is combined with CRA only or CRA plus CM.
Translation and Validation of the COMM and ASI-SR
Opioid UseOpioid Use Disorder3 moreThe goal of this observational study is to translate the COMM form and validate it using the ASI-SR in a Swedish population of pain patients treated with opioids. The secondary aim is to investigate acceptability of the instrument in a Swedish population of pain patients with long-term opioid treatment (LOT). The tertiary aim is to investigate the prevalence of alcohol and illicit substance use in a Swedish population of pain patients with LOT.
Friendship Bench Adaptation to Improve Mental Health & HIV Care Engagement Outcomes Among PLWH and...
HIV InfectionsBehavioral Symptoms6 moreThis project will adapt and pilot a feasible and effective problem-solving therapy designed for low-resource settings to address common mental disorders like depression and anxiety - the Friendship Bench- in a Vietnamese population of individuals living with HIV who also have opiate use disorder. The Friendship Bench approach has the potential to make an important contribution to address CMDs and reduce barriers to HIV treatment success among people living with HIV (PLWH) with Opioid Use Disorder (OUD), a critical population driving the HIV epidemic in Vietnam and many Southeast Asian countries. This proposal will generate critical evidence for designing a fully powered clinical trial to test the investigation team's adapted FB protocol in improving HIV, mental health, and drug use treatment outcomes for this vulnerable population.