search

Active clinical trials for "Optic Neuropathy, Ischemic"

Results 1-10 of 43

ENDOTHELION Study Group: Effect of Bosentan in NAION Patients

Ischemic Optic Neuropathy

Acute ischemic optic neuropathy are the second leading cause of optic neuropathy after glaucoma in the population aged over 50 years. The visual prognosis of the condition is unfavorable in the great majority of cases, with significant effects on the visual field and vision. The severity of the unilateral condition is also associated with bilateralization in 15% at 5 years. There is no effective treatment for the acute phase of the disease or to reduce the rate of bilateralization. In this context, it is essential to develop new therapeutic strategies in the acute phase of the disease to reduce the anatomical optic nerve damage.

Recruiting20 enrollment criteria

Stem Cell Ophthalmology Treatment Study II

Retinal DiseaseAge-Related Macular Degeneration17 more

This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.

Recruiting12 enrollment criteria

Efficacy of Tocilizumab for the Treatment of Acute AION Related to GCA

Giant Cell ArteritisOptic Ischaemic Neuropathy

AION is the main cause of blindness in patients with GCA. High dose steroid is the reference treatment of this condition, but medical unmet need remains. Subcutaneous tocilizumab, a targeted biotherapy, recently received marketing authorization for the treatment of GCA, but only demonstrated at yet that it can allow steroid dose sparing. The aim of this study is to assess the benefit of tocilizumab and IV steroids combination or IV steroids alone, in the treatment of AION due to GCA.

Recruiting25 enrollment criteria

New Non-invasive Modalities for Assessing Retinal Structure and Function

Ischemic Optic NeuropathyBranch Retinal Artery Occlusion3 more

This study investigates a new technology to assess the structure and function inside the eye. Retinal imaging of subjects with inner and outer retinal defects to detect areas of abnormal structure and function compared to other visual function tests.

Recruiting16 enrollment criteria

Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.

Ischemic Optic NeuropathyOptic Neuritis4 more

The aim of the project is to create a new, non-invasive and safe protocol for the early diagnosis of various types of optic neuropathies with the use of diffusion magnetic resonance imaging

Recruiting2 enrollment criteria

NA-AION Risk Factors: New Perspectives

Non-arteritic Ischemic Optic NeuropathyOptic Disk Drusen

The purpose of the study is to use new diagnostic methods (OCT and OCT-A) to shed light on risk factors for the development of NA-AION. The risk factors we are focusing on are comorbidities along with anatomical and vascular characteristics of the optic nerve.

Recruiting10 enrollment criteria

Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic...

Nonarteritic Anterior Ischemic Optic Neuropathy

This study is designed as a double-masked, randomized, placebo-controlled, clinical study to evaluate the efficacy and safety of subcutaneous (SC) administration of RPh201 in participants with previous NAION. All participants enrolled in Cohort A of the study will have a documented history of NAION for at least 12 months and at most, five years prior to enrollment. Participants enrolled in Cohort B of the study will have a documented history of NAION for at least 6 months and at most, three years prior to enrollment.

Terminated57 enrollment criteria

Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic...

Non Arteritic Anterior Ischemic Optic Neuropathy

This study will determine the effect of QPI-1007 on visual function in subjects with recent-onset NAION and assess the safety and tolerability of intravitreal injections of QPI-1007 in this population. This study will also evaluate the structural changes in the retina following administration of QPI-1007.

Terminated10 enrollment criteria

NT-501 CNTF Implant for Ischemic Optic Neuropathy: Safety, Neuroprotection and Neuroenhancement...

Ischemic Optic Neuropathy/Optic Nerve Stroke

Ciliary Neurotrophic Factor (CNTF) has been demonstrated in multiple preclinical models to enhance survival and regeneration of retinal ganglion cells, the retinal neurons injured in diseases like ischemic optic neuropathy/optic nerve stroke. We hypothesize that CNTF delivery to the human eye will provide neuroprotection (prevent loss of vision) and neuroenhancement (improve vision indices) in ischemic optic neuropathy. Patients in the trial will receive an NT-501 CNTF implant (made by Neurotech) into one eye, and will be carefully followed to evaluate safety and efficacy.

Completed11 enrollment criteria

Neurotomy of Optic Nerve in Non-Arthritic Anterior Ischemic Optic Neuropathy

Non Arthritic Anterior Ischemic Optic Neuropathy

Non-arthritic anterior ischemic optic neuropathy is the most common cause of sudden visual loss due to optic nerve involvement in patients above 50 years old. As this problem can be considered as a sclera out let syndrome an there is no effective and successful treatment for it, we decided to do a neurotomy procedure and relax the involved optic nerve in order to achieve acceptable treating outcome.

Completed7 enrollment criteria
12...5

Need Help? Contact our team!


We'll reach out to this number within 24 hrs