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Active clinical trials for "Primary Ovarian Insufficiency"

Results 81-90 of 133

A Study To Compare The Amount Of Premarin Components That Is Absorbed Into The Blood Of Japanese...

Primary Ovarian InsufficiencyVaginitis2 more

The purpose of this study is to assess the bioequivalence and food effect for a new Premarin formulation compared with a Premarin reference tablet in Japanese healthy postmenopausal women.

Completed4 enrollment criteria

Human Amniotic Epithelial Cells Treatment for Ovarian Insufficiency

Premature Ovarian Failure

This project will investigate the safety and effectiveness of human amniotic epithelial cells in primary ovarian insufficiency patients and provide a new cell therapy against infertility.

Unknown status6 enrollment criteria

Effects of ADSC Therapy in Women With POF

Premature Ovarian Failure

The purpose of this study is to determine whether Adipose Derived Stem Cells are effective in the treatment of Premature Ovarian Failure (POF). Stem cell transplantation has been reported to rescue ovarian function in a pre-clinical mouse model of chemotherapy-induced POF; however, maintaining the survival of transplanted cells in human ovarian tissues to enable the POF patients regain ovary function over the long-term and achieving a successful pregnancy remain a troublesome issue. In this study the investigators are aiming to determine whether the CD29+/CD44+ human Adipose Derived Stem Cells could later enable ovaries produce mature oocytes.

Unknown status16 enrollment criteria

Autologous Adipose Derived Mesenchymal Stromal Cells Transplantation in Women With Premature Ovarian...

Premature Ovarian Failure

The goal of this study is to determine safety and tolerability and of intra-ovarian injection of adipose derived stromal cell in women with premature ovarian failure and to study the preliminary efficacy ADSCs intra ovarian injection on ovarian function improvement.

Unknown status9 enrollment criteria

Stem Cell Therapy Combined Hormone Replacement Therapy in Patients With Premature Ovarian Failure...

Premature Ovarian Failure,

Premature ovarian failure (POF) refers the occurrence of amenorrhoea, elevated serum gonadotrophins and hypoestrogenism levels in female before the age of 40. It has important physical and psychological consequences/impact in those patients. Premature ovarian failure (POF) is currently managed by non-physiological sex steroid regimens which are inadequate at optimizing uterine characteristics. Human umbilical cord mesenchymal stem cells (hUCMSCs) and human cord blood mononuclear cells (hCBMNCs) have been shown to have the ability to modulate the immune response and enhance angiogenesis, suggesting the novel and promising therapeutic strategy for POF. In this study, the safety and efficacy of hUCMSCs and hCBMNCs transplantation combined with Hormone Replacement Therapy will be evaluated in patients with Premature Ovarian Failure. Participants will be followed for an expected average of 48 weeks.

Unknown status11 enrollment criteria

Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation

MenopauseMenopause Ovarian Failure25 more

SEGOVA procedure includes - Stem cell therapy, G - Growth factor Platelet Plasma Rich therapy and in Vitro Activation of the ovaries.

Unknown status15 enrollment criteria

Effect of Testosterone Treatment on Embryo Quality

Primary Ovarian InsufficiencyFemale Infertility Due to Diminished Ovarian Reserve

The purpose of this study is to determine the effect of treatment with trans-dermal testosterone cream compared to placebo on measures of ovarian reserve, oocyte and embryo quality, and pregnancy rates among women with evidence of diminished ovarian reserve that have persistently low serum testosterone and free testosterone after completing six previous weeks of DHEA supplementation.

Unknown status10 enrollment criteria

Autologous Bone Marrow-Derived Stem Cell Transplantation in Patients With Premature Ovarian Failure...

Premature Ovarian Failure

This is an open label, single arm, single center investigation to assess the safety and efficacy of purified adult autologous bone marrow derived specific populations of stem cells and mesenchymal stem cells injected into the ovaries (intraovarian injection), through a 12 week follow-up period. The investigators' chosen model of study is based on increasing the efficiency of the approach by choosing an autologous model which preserves the genetic composition of an individual that is vital in infertility conditions. Additionally the approach involves transplanting a combination of specific purified stem cell types which all aid in ovarian function recovery.

Unknown status10 enrollment criteria

Ovarian Fragmentation Study (Crespo Medical Team)

Ovarian FailurePremature Ovarian Failure1 more

This is a study designed to validate Kawamura´s theory and investigation of activation of primordial follicles through ovarian cortex fragmentation. Our aim is to evaluate embryo quality following this procedure in poor ovarian responders and patients with decreased ovarian reserve. Secondary objectives are to assess potential association with the number of oocytes retrieved and pregnancy rates after IVF.

Unknown status16 enrollment criteria

Mesenchymal Stem Cells (MSCs) - Like Cell Transplantation in Women With Primary Ovarian Insufficiency...

Primary Ovarian Insufficiency

There is a high incidence of women suffering from Primary Ovarian Insufficiency (POI). So far, there was no treatment sufficient enough to cure POI. Cell therapy is a rapidly developing field and have shown immense promise in the treatment of ovarian dysfunction. In this study, the investigator will evaluate the safety of MSC-like cell therapy in women suffering from POI.

Unknown status23 enrollment criteria
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