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Active clinical trials for "Ovarian Neoplasms"

Results 31-40 of 2005

huCART-meso + VCN-01 in Pancreatic and Ovarian Cancer

Pancreatic CancerSerous Ovarian Cancer

This is a Phase I study evaluating the safety and feasibility of lentiviral transduced huCART-meso cells when given in combination with VCN-01 in a 3+3 dose (de)escalation design.

Recruiting36 enrollment criteria

GEN1047 for Solid Tumors - First in Human (FIH) Trial

Breast CancerBreast Neoplasms5 more

The drug investigated in the study is an antibody, GEN1047. Since this is the first study of GEN1047 in humans, the main purpose is to evaluate safety. Besides safety, the study will determine the recommended GEN1047 dose to be tested in a larger group of participants and assess preliminary clinical activity of GEN1047. GEN1047 will be studied in a broad group of cancer participants, having different kinds of solid tumors. All participants will get GEN1047. The study consists of two parts: Part 1 tests increasing doses of GEN1047 ("escalation"), followed by Part 2 ("expansion") which tests the recommended GEN1047 dose from Part 1.

Recruiting24 enrollment criteria

A Study of ZN-c3 and Niraparib in Subjects With Platinum-Resistant Ovarian Cancer

Ovarian CancerPlatinum-resistant Ovarian Cancer2 more

This is a Phase 1/2 study to evaluate the safety, clinical activity, pharmacokinetics (PK), and pharmacodynamics (PD) of ZN-c3 in combination with niraparib in subjects with platinum-resistant ovarian cancer.

Recruiting25 enrollment criteria

Niraparib With beVAcizumab After Complete cytoreductioN in Patients With ovArian Cancer

Ovarian Cancer

Randomized, open label, phase II multicenter study to assess the efficacy niraparib versus niraparib +bevacizumab maintenance in patients with newly diagnosed stage IIIA/B/C high-grade epithelial ovarian cancer with no residual disease after frontline surgery and treatment by adjuvant platinum-basedchemotherapy +/-bevacizumab.

Recruiting53 enrollment criteria

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent...

Ovarian Cancer

This study will evaluate the efficacy and safety of multiple biomarker-selected treatments in patients with persistent or recurrent rare epithelial ovarian, fallopian tube, or primary peritoneal tumors. Enrollment will take place in two phases: a preliminary phase followed by a potential expansion phase.

Recruiting24 enrollment criteria

A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha...

Ovarian CancerOvarian Neoplasms23 more

This study, ELU- FRα-1, is focused on adult subjects who have advanced, recurrent or refractory folate receptor alpha (FRα) overexpressing tumors considered to be topoisomerase 1 inhibitor-sensitive based on scientific literature, and, in the opinion of the Investigator, have no other meaningful life-prolonging therapy options available. ELU001 is a new chemical entity described as a C'Dot drug conjugate (CDC), consisting of payloads (exatecans) and targeting moieties (folic acid analogs) covalently bound by linkers to the C'Dot particle carrier. ELU001 will be the first drug-conjugate of its kind to be introduced into the clinic, a first in class, and a novel molecular entity.

Recruiting23 enrollment criteria

Dose Escalation of Lapatinib With Paclitaxel in Ovarian Cancer

Ovarian Cancer

This trial will be a phase I dose-escalation study of lapatinib and paclitaxel for platinum-resistant ovarian cancer, which will establish the phase II dose for subsequent efficacy trials.

Recruiting11 enrollment criteria

CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors

HER2-positiveAdenocarcinoma37 more

Phase 1, first-in-human, open label study of CAR macrophages in HER2 overexpressing solid tumors.

Recruiting17 enrollment criteria

D9319C00001- 1L OC Mono Global RCT

Ovarian Cancer

This is a Phase III, randomised, double-blind, placebo-controlled, multicentre, international study assessing the efficacy and safety of maintenance olaparib compared with placebo in BRCAwt participants with Stage III to IV high grade serous or endometroid ovarian cancer (including fallopian tube cancer or primary peritoneal cancer) who are in complete or partial response following treatment with standard first-line platinum-based chemotherapy.

Recruiting28 enrollment criteria

A Phase III Study of BD0801 Combined With Chemotherapy in Recurrent, Platinum-resistant Epithelial...

Ovarian Cancer

The standard systemic treatment for ovarian cancer is platinum-based chemotherapy. However, majority of patients relapse and eventually progress to platinum resistance. In patients with platinum-resistant or refractory ovarian cancer, effective treatment options are limited and the prognosis is very poor. Angiogenesis is essential for tumor growth and metastasis, and VEGF/VEGF receptor(VEGFR) signaling pathway is the most promising angiogenic target. This study aim to assess the efficacy and safety of the combination BD0801 and chemotherapy in patients with platinum-resistant recurrent ovarian cancer.

Recruiting8 enrollment criteria
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