Emotion, Mood and Executive Function in Parkinson's Disease (PD)
Parkinson DiseaseThe current study aims to assess the effect of an 8 week Azilect treatment (as adjunct therapy to levodopa) on affect perception and emotional expressiveness in a double-blind placebo-controlled study.
Vitamin B6, B12, Folic Acid and Exercise in Parkinson's Disease
Parkinson's DiseaseThis experiment seeks to determine whether individuals with PD will benefit from vitamin B6 (pyridoxine hydrochloride), B12 (cyanocobalamin), and Folic Acid supplementation, whether they will benefit from a 6-week circuit training program, or whether they will benefit from a combination of the two interventions. The outcome variables will include: plasma homocysteine, GSH:GSSG ratio, cognitive function, balance, strength, functional activities, kinematic gait analysis, and a quality of life questionnaire.
A Randomised Controlled Trial (RCT) to Evaluate Use of an Individual Auditory Cueing Device's (IACD's)...
Parkinson's DiseaseThe primary aim of the study is to evaluate the effect of an IACD i.e. Apple iPod-shuffle, on freezing and gait speed in people with a diagnosis of PD through the implementation of a randomised controlled trial. A secondary aim of the study is to evaluate the impact of such a device on the quality of life of people with stroke through the administration of a self-report questionnaire. The IACD will be pre-loaded with an individualised auditory cueing frequency (metronome sound) matched to the walking speed of the individual with PD.
Botulinum A Toxin in Patients With Parkinson's Disease
Parkinson's DiseaseMultiple System Atrophy1 moreThe researchers investigated the effectiveness and safety of BoNT/A injected into the detrusor muscle in patients with PD and MSA all of whom had detrusor muscle overactivity unresponsive to conventional medical therapy.
Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders....
Movement DisordersParkinson Disease3 moreThe purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
Randomized Study of Fetal Neurotransplantation for the Treatment of Parkinson's Disease
Parkinson DiseaseOBJECTIVES: I. Assess the safety and efficacy of embryonic mesencephalic dopamine cell implants into the putamen of patients with Parkinson's disease.
Safety and Initial Effectiveness of Transcranial MR Guided Focused Ultrasound for the Treatment...
Parkinson DiseaseSafety and Effectiveness in ExAblate Neuro treatment of medication-refractory tremor in subjects with idiopathic Parkinson's disease.
A Study of Efficacy and Safety of Idebenone vs. Placebo in Prodromal Parkinson Disease
REM Sleep Behavior DisorderParkinson DiseaseTo investigate whether 24 months of idebenone may reduce the progression from Prodromal Parkinson disease (PPD) to Parkinson disease (PD).
Parkinson's Disease Therapy Using Cell Technology
Transplantation:Mesenchymal Stem Cell TransplantationTreatment of patients with Parkinson's disease using mesenchymal stem cells is a perspective method to influence on the pathogenesis of the disease. At the same time, this is a complex and still insufficiently explored process. Autologous mesenchymal stem cells will be transplanted to 30 patients with Parkinson's disease. The results of the effectiveness of the combined and intravenous routes of mesenchymal stem cells administration on the motor and non-motor symptoms in these patients will be evaluated and compared with the results of control group that received placebo therapy
Cerebellar rTMS Theta Burst for Dual-task Walking in Parkinson's Disease
ParkinsonParkinson Disease5 moreObjective of the study: To test the efficacy of theta burst cerebellar stimulation on dual task walking in Parkinson's disease using a cross-over design and wearing sensors technology Design: Twenty Parkinson's disease patients with no dementia will be recruited for a cross-over sham-controlled study. Each patient will undergo a sham stimulation or a single session of cerebellar theta burst stimulation with a wash out period of at least 14 days. Each patient will be evaluated before and after stimulation by a battery of gait and movement tests using wearing sensors technology .