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Active clinical trials for "Peripheral Nervous System Diseases"

Results 51-60 of 918

A Study to Evaluate the Effect of Spinal Cord Stimulation (SCS) on Painful Diabetic Peripheral Neuropathy...

Chronic Pain

The purpose of the study is to evaluate the effects of stimulation parameters on clinical outcomes of Spinal Cord Stimulation (SCS) in the treatment of chronic, intractable limb pain resulting from painful Diabetic Peripheral Neuropathy (pDPN).

Recruiting10 enrollment criteria

Pain and Neurological Function Improvements With 10 kHz Spinal Cord Stimulation Treatment of Painful...

Painful Diabetic Neuropathy

The purpose of this post-market study is to evaluate changes in pain and neurological function with high frequency, 10 kHz spinal cord stimulation (SCS) therapy in patients with chronic, intractable lower limb pain associated with diabetic peripheral neuropathy, a condition known as painful diabetic neuropathy (PDN). This is a multi-center, prospective, randomized controlled study to evaluate improvement in pain and neurological function in PDN patients, with neurological function assessed via objective measures. Patients will be randomized to conventional medical management (CMM) or 10 kHz SCS plus CMM.

Recruiting32 enrollment criteria

A Study to Investigate the Safety and Efficacy of Ricolinostat

Peripheral Nervous System Diseases

This is a double-blind, placebo-controlled study during which patients will receive ricolinostat or placebo.

Recruiting18 enrollment criteria

Implementation of Telemedicine for Patient With Lower Extremity Wounds

Peripheral Arterial DiseasePeripheral Artery Disease5 more

The objective of this study is to determine if patients with lower extremity wounds in rural communities who undergo specialty referral through telemedicine have expedited care compared to patients who are treated through standard in person referral.

Recruiting4 enrollment criteria

Wearable Focal Vibration for Chemotherapy-Induced Peripheral Neuropathy

Chemotherapy-induced Peripheral Neuropathy

This study will perform an early Phase I feasibility study with single-arm, double-baseline repeated measured design. The investigators will test the feasibility of using focal vibration to improve symptoms of persistent CIPN.

Recruiting11 enrollment criteria

Stem Cell Ophthalmology Treatment Study II

Retinal DiseaseAge-Related Macular Degeneration17 more

This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.

Recruiting12 enrollment criteria

EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy

Painful Diabetic Neuropathy

This is a Platform Protocol to perform Phase II clinical trials in The Early Phase Pain Investigation Clinical Network (EPPIC-Net), under The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, related to the treatment of Painful Diabetic Peripheral Neuropathy (PDPN) in a platform setting to test multiple assets under a single protocol.

Recruiting63 enrollment criteria

The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)...

Chemotherapy-Induced Peripheral Neuropathy

The purpose of this study is to test whether yoga can reduce nerve pain caused by cancer treatment (chemotherapy-induced peripheral neuropathy, or CIPN). Participants will take one of three approaches: Yoga classes Educational sessions on the causes and impacts of CIPN, how yoga may help with CIPN, and how different therapies may help with CIPN Usual care with standard-of-care medications for CIPN The researchers will compare how these different approaches affect participants' balance, their risk of falls, and their quality of life. This study will also measure how much yoga can help the reduced sense of touch caused by CIPN. The functional assessments TUG and CTS can be safely completed either virtually and in-person and will be mandatory for all patients. The functional assessment FRT and QST assessments that can only be completed in-person are optional at these time points.

Recruiting10 enrollment criteria

External Shoe Lift to Improve Healing and Adherence in Patients With Diabetic Foot Ulcers

Diabetic Foot UlcerPeripheral Neuropathy1 more

Previous researches hipothesize that imposed limb-length discrepancies may discourage adherence in patients with active diabetic foot ulcer and using offloading devices. Our hipothesis is that the use of an external shoe lift contralaterally to the affected foot may improve adherence to offloading devices and improve healing.

Recruiting10 enrollment criteria

Effects of Cryotherapy on Taxane-Induced Neuropathy in Patients With Breast Cancer

CIPN - Chemotherapy-Induced Peripheral NeuropathyBreast Cancer

Due to well-proven survival benefit, paclitaxel and other taxane-based chemotherapies are first-line agents for both the adjuvant and neoadjuvant treatment of early stage breast cancer. Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and disabling side effect of taxane anticancer agents. No established strategy exists for CIPN prevention. This study is designed to assess the efficacy and safety of cryotherapy for the prevention of paclitaxel-induced peripheral neuropathy in patients with breast cancer in a prospective randomized controlled trial.

Recruiting2 enrollment criteria
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