Efficacy of Perindopril to Prevent Recurrence of Atrial Fibrillation in Patients With Essential...
Essential HypertensionAtrial FibrillationThe purpose of this 7- to 13-month study is to determine the efficacy of 8 mg/day oral perindopril to prevent the recurrence of atrial fibrillation (AF) in patients with essential hypertension.
Efficacy & Safety of Dronedarone Versus Amiodarone for the Maintenance of Sinus Rhythm in Patients...
Atrial FibrillationThe objective of this study is to compare the efficacy and safety of dronedarone to that of amiodarone for the treatment of patients with atrial fibrillation.
RAte Control Efficacy in Permanent Atrial Fibrillation
Persistent Atrial FibrillationThe investigators hypothesis is that in patients with permanent AF lenient rate control is not inferior to strict rate control in terms of cardiovascular mortality, morbidity, neurohormonal activation, NYHA class for heart failure, left ventricular function, left atrial size, quality of life and costs. Lenient rate control is defined as a resting heart rate <110 bpm.Strict rate control is defined as a mean resting heart rate < 80 beats per minute (bpm) and heart rate during minor exercise < 110 bpm. Patients will be seen after 1, 2, 3 months (for titration of rate control drugs) and thereafter yearly.
Study of Ablation Versus antiaRrhythmic Drugs in Persistent Atrial Fibrillation
Atrial FibrillationThe purpose of this study is to compare the effectivity and safety of atrial fibrillation ablation, in comparison to antiarrhythmic drug therapy in patients with refractory, persistent atrial fibrillation.
Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation...
Atrial FibrillationThe optimal strategy to restore sinus rhythm in patients with atrial fibrillation (AF) of less than 48 hours' duration is still controversial. The investigators performed a controlled single-center trial to compare electrical and pharmacological (propafenone) cardioversion to restore the sinus rhythm in selected patients with acute atrial fibrillation.
Randomized Trial of Two Different Strategies to Treat Paroxysmal Atrial Fibrillation
Atrial FibrillationThe purpose of this study is to investigate the significance of complete versus incomplete electrical isolation of pulmonary veins by radiofrequency-induced linear lesions in patients with paroxysmal atrial fibrillation. The study hypothesis ist that the complete linear PV isolation ablation is superior to the non-complete linear PV isolation on the outcome of patients with idiopathic drug-refractory atrial fibrillation. As a second hypothesis in this adaptive study design, the non-inferiority of the complete linear PV isolation strategy will be tested.
Study of RSD1235 to Evaluate Safety in Patients With Atrial Fibrillation
Atrial FibrillationThis study is designed to determine the safety of RSD1235 in patients with atrial fibrillation.
RATe Control in Atrial Fibrillation
Atrial FibrillationThe purpose of this study is to compare the effect of metoprolol, verapamil, diltiazem and carvedilol on ventricular rate, working capacity and quality of life in patients with chronic atrial fibrillation.
STAR-AF:Substrate Versus Trigger Ablation for Reduction of Atrial Fibrillation Trial
Atrial FibrillationPatient Population: Patients with AF that is symptomatic and refractory to at least one antiarrhythmic medication. Patients must have AF that is paroxysmal (>4 episodes within 6 months, two episodes >6 hours within 1 year) or persistent (sustained episode <6 months terminated by cardioversion or drug). Purpose: To compare a trigger-based technique (pulmonary vein isolation) to a substrate-based technique (high-frequency, fractionated EGMs) to a combined approach for AF ablation
To Evaluate the Impact of Oral Flecainide on Quality of Life in Patients With Paroxysmal Atrial...
Atrial FibrillationThe purpose of this study is to evaluate the management of paroxysmal atrial fibrillation with controlled release flecainide on patient's quality of life.