Evaluation of the Cardioblate CryoFlex Surgical Ablation System in Longstanding Persistent Atrial...
Longstanding Persistent Atrial FibrillationStudies have shown that taking drugs to stay out of AF has limited success. This research is designed to study heart rhythm after surgical therapy, namely by measuring if there are benefits to having surgery to treat Atrial Fibrillation (AF) with the Cardioblate CryoFlex Surgical Ablation System. The system is approved and commercially available with CE mark. The purpose of this study is to support clinical evidence that the Cardioblate System is safe and effective to treat AF.
Canadian EdoxAban(Lixiana®) Registry in Patients With ATrial Fibrillation/Flutter With Confirmed...
Atrial Fibrillation and FlutterValvular Heart DiseaseThe objective of this registry is the characterization of patients with atrial fibrillation (AF) and/ or atrial flutter (AFL) with confirmed VHD who are prescribed edoxaban in a real life clinical setting.
Definition, Quantification, and Utility of Biomarkers of Repetitive Brain Injury in Predicting Concussion...
Cognitive ChangeThis is a prospective clinical study designed to evaluate biomarkers of brain injury and dementia incidence and moderate cognitive decline rates in moderate- to high-risk atrial fibrillation patients that undergo standard of care atrial fibrillation management.
Real-world Study on Edoxaban Treatment for Patients With Non-valvular Atrial Fibrillation in China...
Non-valvular Atrial FibrillationThe safety of edoxaban treatment will be examined using real-world clinical evidence from adult patients with non-valvular atrial fibrillation (NVAF) indications in routine clinical practice.
Long Term Arrhythmia Risk and Cardiovascular Events in Hematopoietic Stem Cell Transplant
Hematopoietic Stem Cell TransplantAtrial Fibrillation1 moreThe purpose of this study is to better understand the following aims: Aim 1: To evaluate the rate of recurrent Atrial Fibrillation (AF)/Atrial Flutter (AFL) in hematopoietic stem call transplant (HCST) patients with incident AF/AFL identified during the initial 30 days of the transplant Aim 2: To evaluate incident episodes of 1) stroke/TIA; 2) other thromboembolic events (not stroke/TIA); 3) Heart failure events; 4) Ischemic heart events Aim 3: To evaluate overall implantation safety in this population
Effects of Dronedarone on Cardiac Geometry and Function in Patients With Atrial Fibrillation and...
Atrial FibrillationPrimary Objective: - Evaluate the effect of dronedarone versus placebo (standard therapy) in slowing the progression of adverse left atrial remodeling in patients with atrial fibrillation (AF) following 12 months of treatment. Secondary Objectives: Evaluate the effects of dronedarone versus placebo on left atrial function; Evaluate the effects of dronedarone versus placebo on left atrial dimension; Evaluate the effects of dronedarone versus placebo on left ventricular function (LVEF, E, E', A, E/E') Evaluate the safety and tolerability of dronedarone.
Atrial Fibrillation: Ablation or Surgical Treatment II: FAST II
Paroxysmal Atrial Fibrillation.The purpose of this study is to compare two invasive treatments of symptomatic paroxysmal atrial fibrillation: Percutaneous radiofrequency catheter ablation and mini invasive thoracoscopic radiofrequency ablation in patients referred for a first time invasive treatment for atrial fibrillation. The hypothesis is, that mini invasive thoracoscopic radiofrequency ablation as a first time invasive treatment is more effective compared to a percutaneous catheter based technique in patients with symptomatic paroxysmal atrial fibrillation refractory or intolerant to at least one antiarrhythmic drug.
Ranolazine for the Prevention of Atrial Fibrillation After Electrical Cardioversion
Atrial FibrillationThe investigators hypothesize that ranolazine would decrease the incidence of recurrence of Atrial Fibrillation (AF) after electrical cardioversion of persistent AF. Patients with persistent AF who are candidates for electrical cardioversion will be randomized to either placebo or ranolazine after successful electrical cardioversion.
Concomitant Epicardial Pulmonary Vein Isolation in Patients With Atrial Fibrillation Undergoing...
Atrial FibrillationRecent studies demonstrated that radiofrequency isolation of the pulmonary veins (PVI) is a superior alternative to antiarrhythmic drug therapy in patients with symptomatical paroxysmal atrial fibrillation (AF). A substantial proportion of patients undergoing elective cardiac surgery also suffer from atrial fibrillation. No evidence exists if epicardial PVI is beneficial in patients with a history of AF undergoing coronary bypass surgery (CABG) for the concomitant treatment of AF. The investigators aim to establish the effectiveness of incorporating epicardial pulmonary vein isolation into elective cardiac surgery.
Use of the Hansen Medical System in Patients With Paroxysmal Atrial Fibrillation
Paroxysmal Atrial FibrillationThe purpose of this study is to assess the safety and performance of the Hansen Medical Sensei Robotic System and Artisan Catheter when used to robotically manipulate RF ablation catheters for the treatment of paroxysmal atrial fibrillation (irregular heartbeats originating in the upper chambers of the heart).