Population Pharmacokinetics and Dosage Individualization of Oral Pulmonary Vasodilators in PPHN...
Persistent Pulmonary Hypertension of the NewbornThe use of bosentan, sildenafil and tadalafil in neonates with persistent pulmonary hypertension (PPHN) depends mostly on the empirical experience of pediatricians. Moreover, the recommended dose of those three drugs in treating PPHN remains controversial. Therefore, our aim is to study the pharmacokinetics and pharmacodynamics of bosentan, sildenafil and tadalafil in neonates of PPHN then dose a tailor-made therapeutic regimen.
Doppler Ultrasonographic Assessment of Fetal Internal Thoracic Artery Indexes
Pregnancy RelatedFetal; CirculationThe aim of this study is to assess the feasibility of visualizing the internal thoracic artery (ITA), establishing the normogram for ITA pulsatility index (PI), resistance index (RI) and acceleration/ejection time (AT/ET) at 24-32 weeks.
Plethismographic Perfusion Index in Neonates
Patent Ductus ArteriosusPersistent Pulmonary Hypertension of the NewbornPhotoplethismography will be measured and compared in newborns suffering from patent ductus arteriosus and normal controls.
