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Active clinical trials for "Retinitis Pigmentosa"

Results 131-140 of 222

Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa

Retinitis PigmentosaRetinal Diseases4 more

The purpose of this study is to evaluate the efficacy and safety of oral valproic acid to slow the progression of visual function and/or to improve the visual function in patients with retinitis pigmentosa (RP). Enrolled subjects in valproic acid group will be treated with oral valproic acid 500mg daily for 48 weeks. Visual function and safety will be assess before and after treatment (48 weeks) between valproic acid and control groups.

Completed19 enrollment criteria

Safety/Proof of Concept Study of Oral QLT091001 in Subjects With Leber Congenital Amaurosis (LCA)...

LCA (Leber Congenital Amaurosis)RP (Retinitis Pigmentosa)

The purpose of this study is: to evaluate the safety of oral QLT091001 to evaluate whether 7-day treatment with oral QLT091001 can improve visual function in subjects with LCA or RP due to RPE65 or LRAT mutations to evaluate duration of visual function improvement (if observed)

Completed9 enrollment criteria

Management of Cystoid Macular Edema Secondary to Retinitis Pigmentosa Via Subliminal Micropulse...

Retinitis PigmentosaCystoid Macular Edema

Purpose: To investigate the effects of subliminal micropulse yellow laser application on central macular thickness and best corrected visual acuity in cystoid macular edema secondary to retinitis pigmentosa patients.

Completed9 enrollment criteria

Gene Therapy for X-linked Retinitis Pigmentosa (XLRP) - Retinitis Pigmentosa GTPase Regulator (RPGR)...

X-Linked Retinitis Pigmentosa

The Phase 1 part of the study is a dose escalation of subretinal administration of AAV2/5 vector to assess the safety of this vector in participants with XLRP caused by mutations in RPGR. The Phase 2 part of the study is a cohort expansion of subretinal administration of AAV2/5 vector to assess the safety and efficacy of this vector in participants with XLRP caused by mutations in RPGR.

Completed5 enrollment criteria

Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects...

Retinitis Pigmentosa

The primary objective of the study is to assess the safety of repeat injection of human retinal progenitor cells (jCell) in adult subjects with RP that have previously been treated with jCell.

Completed17 enrollment criteria

Nerve Growth Factor Eye Drops Treatment in Patients With Retinitis Pigmentosa and Cystoid Macular...

Retinitis PigmentosaCystoid Macular Edema

This study aims at investigating the therapeutic potential of recombinant human Nerve Growth Factor ( rhNGF ) eye drops treatment in patients with Retinitis Pigmentosa (RP) associated with cystoid macular edema (CME) in a phase II, randomized, double-masked, controlled clinical trial.

Completed26 enrollment criteria

Argus® II Retinal Stimulation System Feasibility Protocol

Retinitis Pigmentosa

Investigational Phase of the Study: The objective of this feasibility study is to evaluate the safety and utility of the Argus II Retinal Stimulation System in providing visual function to blind subjects with retinitis pigmentosa. Post-Approval Phase of the Study: To collect post-approval data in order to monitor the ongoing safety and reliability of the Argus II System

Completed34 enrollment criteria

Restoring Vision With the Intelligent Retinal Implant System (IRIS V1)in Patients With Retinal Dystrophy...

Retinitis PigmentosaCone Rod Dystrophy1 more

This study evaluates the safety and effectiveness of the Intelligent Retinal Implants System (IRIS V1)

Completed39 enrollment criteria

Transcorneal Electrostimulation for Therapy of Retinitis Pigmentosa

Retinitis Pigmentosa

The purpose of this study is to determine the long-term effects of transcorneal electrostimulation (TcES) in patients with retinitis pigmentosa (RP). In a prior study (NCT00804102) the results of short-term stimulation showed a positive effect on the visual field and other parameters. In this study, the patients will be stimulated with either 0%, 150% or 200% of the individually determined phosphene threshold.

Completed19 enrollment criteria

Transcorneal Electrical Stimulation - Multicenter Safety Study

Retinitis Pigmentosa

The purpose of this study is to expand the safety assessment of repeated applications of an electrical current from a DTL-like electrode in patients with RP.

Completed18 enrollment criteria
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