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Active clinical trials for "Pituitary Neoplasms"

Results 131-140 of 140

Setting Benchmarks for Transsphenoidal Resection of Pituitary Adenomas

Pituitary AdenomaPituitary Tumor1 more

To conduct a retrospective multicenter cohort study to define benchmark values for best achievable outcomes following transsphenoidal resection of pituitary adenomas.

Unknown status3 enrollment criteria

Epidemiology of Pituitary Tumours: Prevalence of Associated Neoplasia

Pituitary TumorEndocrine Neoplasia3 more

The study aims to update current knowledge about the epidemiology of pituitary tumours (PiT), based on the wide body of scientific literature on new familial and/or syndromic forms. Although inherited predisposition is increasingly recognized, its clinical relevance in unselected series of PiT patients has not been specifically addressed. In addition, it is likely that further recognition of peculiar associations between PiT and other endocrine and/or non-endocrine neoplasia will further increase the spectrum of syndromic forms. Since the identification of inherited forms of PiT may have significant clinical implications in terms of patients management and familial screening, we aim to collect any relevant information in order to estimate their prevalence in a large unselected series of PiT patients and provide new clues for a modern clinical approach to these patients.

Unknown status5 enrollment criteria

Genome-wide Association Study of Pituitary Tumors

Pituitary Adenomas

Pituitary adenomas is a very common disease, but the cause and genetics hasn't been identified. The investigators are going to use genome-wide association study to identify genes that may be related to pituitary adenomas.

Unknown status2 enrollment criteria

The Observational Study of Growth Hormone-secreting Pituitary Tumors

AcromegalyPituitary Tumor

The major purpose of this study is to evaluate the changes of multiple organs in patients with growth hormone-secreting pituitary tumors before and after surgery. Plasma, DNA samples and pituitary tumor tissues will be kept for further analysis.

Unknown status2 enrollment criteria

Prevalence of Pituitary Incidentaloma in Relatives of Patients With Pituitary Adenoma

Pituitary Tumor

The purpose of the study is to determine genetic links among blood-relatives and between spouses of patients with pituitary tumors.

Unknown status2 enrollment criteria

A Pilot Study of 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Pituitary Adenomas

Pituitary Adenoma

5-Aminolevulinic Acid (5-ALA) was approved by the FDA as an intraoperative optical imaging agent in patients with suspected high-grade gliomas (HGGs) in 2017. The investigators plan to administer 5-ALA to patients with pituitary tumors to demonstrate whether it can be used as an intraoperative optical imaging agent for this pathology. Overall, this pilot study will afford the overall opportunity to improve surgical management and advancement of the science of neurological and neuroendocrine disease.

Unknown status7 enrollment criteria

Characterization of Receptors in Non-functioning Pituitary Macroadenomas

Pituitary Tumor

Characterization of receptors present in non-functioning pituitary macroadenomas by Reverse Transcriptase- Polymerase Chain Reaction (RT-PCR) would assist with targeted medical therapy based on the information obtained by immunohistochemistry and RT-PCR.

Unknown status6 enrollment criteria

Clinical Study of Structural and Functional Evaluation of the Visual Pathway

Pituitary AdenomaVisual Impairment2 more

Sellar area tumors such as pituitary adenoma, craniopharyngioma and meningioma, etc, commonly lead to visual impairment symptoms. Patients suffer from a loss of visual acuity (VA) and visual field defects (VF) due to a local compression on the optic chiasma by the tumor. In the management of these patients, it is an important goal to evaluate their visual function throughout the treatment, so as to predict the outcome of the visual function . Since the visual pathway contains a huge complex network of both structure and function, traditional simplex evaluation of VA and VF is obviously not enough. Former studies have revealed changes in the visual network and cortex structure in neurodegenerative diseases and optic neuritis, yet the functional and structural changes caused by local tumor compression and their relation to the visual cortex activity patterns needs further research. The objective of this research is to asses the visual function in patients with sellar area tumor 1 week preoperatively (baseline),72 hours postoperatively(checking point 1) and at 3 months follow up(checkpoint 2). By using multimodal evaluation including visual resting and task state fMRI, diffusion tensor imaging (DTI), etc. The investigators aim to reveal the changes in functional connectivity (FC), amplitude of low frequency fluctuation (ALFF), regional homogeneity (REHO) ,visual cortex activity patterns and tract-based spatial statistics (TBSS).

Unknown status9 enrollment criteria

The Impact of Endoscopic Pituitary Surgery on Nasal Function

Pituitary TumorEndoscopic Surgery2 more

The aim of this study is to determine the impact of endoscopic transsphenoidal pituitary surgery on nasal function using a numerical simulation and to compare the difference between two kinds of transsphenoidal approachese(single nostril approach and bilateral nostril approach).

Unknown status11 enrollment criteria

The Predictive Factors of Vision Recovery in Patients With Pituitary Tumor

Pituitary Adenomas

Pituitary adenomas can cause compression of optic nerves and chiasm, which will lead to damage of vision. This study aims to evaluate the predictive factors for recovery of vision in patients with pituitary adenomas following trans-sphenoidal surgery.

Unknown status4 enrollment criteria
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