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Active clinical trials for "Pleural Effusion, Malignant"

Results 51-60 of 125

Ultrasound-guided Biopsy of the Pleura as a Supplement to Extraction of Fluid in Patients With One-sided...

Malignant Pleural EffusionExudative Pleural Effusion

The research group will investigate the diagnostic effect of early introduction of ultrasound guided pleural biopsy in the work-up of patients with one-sided pleural effusion, suspected of malignant pleural effusion.

Terminated9 enrollment criteria

Intrapleural Instillation of the Nivolumab in Cancer Patients With Pleural Effusion.

Renal Cell Cancer MetastaticNon-small Cell Lung Cancer Metastatic2 more

Patients with advanced cancers who have pleural effusion, especially those requiring pleural evacuation, experienced poorer survival when treated with immunotherapy. The pleura also acts as a natural barrier that can limit the penetration of immune checkpoint inhibitors. In this multicenter phase 2 study, the preliminary efficacy and toxicity of intrapleural instillation of the nivolumab in patients with immune-sensitive metastatic cancers will be accessed.

Completed6 enrollment criteria

Endostar and/or Cisplatin for Treatment of Malignant Pleural Effusion or Ascites

Malignant Pleural EffusionMalignant Ascites

The objective of this study is to compare the efficacy of Endostar/cisplatin with cisplatin alone or Endostar alone in patients with malignant pleural effusion or ascites.

Completed14 enrollment criteria

Video-assisted Hyperthermic Pleural Chemoperfusion vs Talc Pleurodesis for Refractory Malignant...

Safety of InterventionEfficacy of Intervention1 more

Aim of this study is to compare two methods of pleurodesis for refractory malignant pleural effusions, in terms of safety and efficacy.

Completed5 enrollment criteria

Tunneled Pleural Catheter in Partially Entrapped Lung

Malignant Pleural Effusion

An open randomized, prospective, single center; parallel group trial to compare efficiency and safety of PleurX-Pleural Catheter versus standard surgical treatment in patients with malignant pleural effusion and partial entrapment of the lung.

Completed17 enrollment criteria

Surgery and Intrapleural Docetaxel in Treating Patients With Malignant Pleural Effusion

Metastatic Cancer

RATIONALE: Giving drugs, such as docetaxel, directly into the pleura after surgery to drain the pleural effusion may help keep fluid from building up again. PURPOSE: This phase I trial is studying the side effects, best way to give, and best dose of intrapleural docetaxel given after surgery in patients with malignant pleural effusion.

Completed42 enrollment criteria

Non-small Cell Lung Cancer Registry

Non-Small-Cell Lung CancerPleural Effusion1 more

This trial will evaluate two separate groups of patients with stage IIIB/IV non-small cell lung cancer. The objective of Group 1 is to investigate an FDA-approved drug in stage IIIB/IV non-small cell lung cancer patients that has spread to the bones. The objective of Group 2 is to see if a blood test can be used to predict when cancer-related bone lesions develop. This trial is seeking patients 18 years or older that have been diagnosed with Stage IIIB or Stage IV non-small cell lung cancer that cannot be treated by surgery.

Completed12 enrollment criteria

Bortezomib Plus Gemcitabine and Carboplatin in Treating Patients With Advanced or Recurrent Non-Small...

Malignant Pleural EffusionRecurrent Non-small Cell Lung Cancer2 more

Bortezomib may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug and bortezomib may kill more tumor cells

Completed40 enrollment criteria

Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small...

Malignant Pleural Effusion

To determine the efficacy and Safety of intrapleural Bevacizumab and cisplatin as a treatment for malignant pleural effusions (MPE) in patients with non-small cell lung cancer (NSCLC).

Completed10 enrollment criteria

Talc Pleurodesis in Patients With Recurrent Malignant Pleural Effusion

Recurrent Malignant Pleural Effusion.

The purpose of this study is to analyze and compare radiological lung expansion after talc pleurodesis performed either by videothoracoscopy or chest tube and correlate it with clinical outcome. Secondary endpoints evaluated were: clinical efficacy, safety, quality of life and survival.

Completed10 enrollment criteria
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