Long Term Study of Canakinumab (ACZ885) in Patients With Gout
Gouty ArthritisThis 24-week open-label extension study is designed to provide additional long-term safety data up to a total of 1-year for patients rolling over from the core study, and to collect further efficacy and tolerability data for all the patients, irrespective whether they have an acute flare of gout or not. Patients will be treated on demand with canakinumab (ACZ885) in this extension study.
Safety and Preliminary Efficacy of MOR103 in Patients With Active Rheumatoid Arthritis
Rheumatoid ArthritisGM-CSF is considered to have a key role in the initiation and progression of arthritic inflammation. The purpose of this study is to evaluate the safety, preliminary efficacy, pharmacokinetics, and immunogenicity of multiple doses of MOR103, a human antibody to GM-CSF, in patients with active rheumatoid arthritis.
A Study of Tocilizumab in Combination With an Oral Contraceptive in Patients With Rheumatoid Arthritis...
Rheumatoid ArthritisThis open-label, randomized, cross-over study evaluated the effect of tocilizumab (TCZ) on the pharmacokinetics and pharmacodynamics of a common oral contraceptive (OC) in female patients with active rheumatoid arthritis (RA) and in healthy female volunteers of child bearing age. The RA patients received OC in combination with TCZ, whereas the healthy volunteers received OC only. The RA patients received OC in 3 cycles of 21 days each; TCZ 8 mg/kg was administered once as an intravenous infusion on the first day of Cycle 2. The healthy volunteers received OC for only one 21-day cycle.
Study of LX3305 and Methotrexate in Subjects With Stable Rheumatoid Arthritis
Rheumatoid ArthritisThe purpose of the study is to evaluate the effect of LX3305 on methotrexate (MTX) pharmacokinetics and to evaluate the safety and tolerability of LX3305 given over 14 days in subjects with stable rheumatoid arthritis that are receiving stable doses of MTX.
Long-term Treatment Study of Certolizumab Pegol Without Coadministration of Methotrexate in Japanese...
Rheumatoid ArthritisThe objectives of this study are to evaluate the safety and efficacy of certolizumab pegol when administered without coadministration of methotrexate over the long term in Japanese RA patients who transferred from Study 275-08-003 (NCT00791921), and to evaluate the effects of different dosing regimens on the safety and efficacy of certolizumab pegol in American College of Rheumatology 20% (ACR20) responders who completed Study 275-08-003.
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
OsteoarthritisTraumatic Arthritis4 moreThe purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
Study to Evaluate SC Route of Administration of Ofatumumab in RA Patients
ArthritisRheumatoidThis study will examine the safety and tolerability, PK and PD of subcutaneously administered GSK1841157 in patients with RA on stable dose Methotrexate. The study comprises a single dose escalation/de-escalation phase to investigate the minimal efficacious dose based on PD markers with an acceptable safety profile.
Assessment of the Effectiveness of Low-Level Laser Therapy on the Hands of Patients With Rheumatoid...
Rheumatoid ArthritisThe purpose of the present study was to assess the effectiveness of low-level laser therapy on the reduction in pain and improvement in function in the hands of patients with rheumatoid arthritis
Follow-up of Rheumatoid Arthritis (RA) Moderate to Low Disease Activity Study
Rheumatoid ArthritisTo continue to assess the clinical safety and efficacy of Certolizumab Pegol as add-on therapy with stable-dose Disease Modifying Anti-Rheumatic Drugs (DMARDs)
An Open Label Extension Study in Participants With Rheumatoid Arthritis
Rheumatoid ArthritisTo evaluate the safety and tolerability of LY2127399 administered as subcutaneous injections for 48 weeks in participants with Rheumatoid Arthritis