A Non-Comparative Study to Assess the Safety of MabThera (Rituximab) in Patients With Rheumatoid...
Rheumatoid ArthritisThis single arm study will assess the safety of MabThera plus methotrexate in patients with rheumatoid arthritis who have had a lack of response to 1-5 DMARDs or biological agents. Patients will receive MabThera (1g i.v.) on days 1 and 15, concomitantly with methotrexate >=15mg p.o./week. The anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals.
Rituxan With or Without Methotrexate in Psoriatic Arthritis
Psoriatic ArthritisThe purpose of this study is to help determine the effectiveness of rituxan (with or without methotrexate) in the treatment of psoriatic arthritis.
A Study of Oral SCIO-469 Pharmacokinetics (Study of a Drug in the Body to Watch How the Drug is...
Rheumatoid ArthritisThe purpose of this study is to assess the pharmacokinetics of two oral dosing regimens of SCIO-469, with and without methotrexate, in patients with active rheumatoid arthritis.
Tai Chi for Patients With Rheumatoid Arthritis
Rheumatoid ArthritisThe purpose of this study was to study the impact of Tai Chi group exercise on physical function, health and disease activity of patients with RA, and to examine the patients' experience and perception of Tai Chi.
Treatment of Arthritis With Syk Kinase Inhibition (TASKI-1)
Rheumatoid ArthritisThis is a Phase II, multicenter, randomized, double-blind, placebo-controlled, ascending dose, dose ranging study to evaluate up to three doses of R935788 (50 mg bid, 100 mg bid and 150 mg bid). Approximately 180 patients who have had rheumatoid arthritis for a minimum of 12 months and who have been receiving a weekly methotrexate (MTX) dose for a minimum of 6 months will be enrolled into the study.
Study of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-biologic...
Rheumatoid ArthritisThe purpose of this study is to summarize the safety and tolerability of abatacept during 6 months of combined treatment with one or more of the background non-biologic disease modifying anti-rheumatic drugs (DMARDs) approved for rheumatoid arthritis (RA) in subjects with active RA. Secondary objectives assessed the clinical efficacy of combination treatment, including disease activity, physical function, and quality of life outcomes.
A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss
CancerCancer Cachexia3 moreThe purpose of this study is to evaluate the safety and effectiveness of fish oil supplements in maintaining weight in people with disease-related weight loss and/or cachexia.
Efficacy, Safety and Tolerability of Denosumab in the Treatment of Rheumatoid Arthritis
Rheumatoid ArthritisThis study will determine the efficacy, safety, and tolerability of denosumab (AMG 162) in the treatment of Rheumatoid Arthritis (RA).
Activity and Safety of Oral Administration of SSR150106XB for the Reduction of Inflammation in Patients...
Rheumatoid ArthritisThe primary objective of this study is to assess the reduction of systemic inflammation as measured by serum levels of C-reactive protein (CRP). The secondary objectives are: to assess the reduction of systemic inflammation as measured changes in acute phase protein, serum amyloid A (SAA) and cytokine interleukin-6 (IL-6), and clinical American College of Rheumatology response rate, and morning stiffness duration; to assess the effect on pain relief within first 14 days; to obtain evidence of the safety and tolerability of SSR150106; to document trough plasma levels of SSR150106 and its first metabolite.
Study Comparing Perceptions and Satisfaction for Two Different Delivery Mechanisms for Etanercept...
Rheumatoid ArthritisThe purpose of this study is to explore and compare the perceptions and satisfaction for two different delivery mechanisms for Etanercept (Etanercept Autoinjector and the Etanercept Prefilled Syringe) in patients with rheumatoid arthritis (RA).