The BCD-089 (aIL6R) in Patients With Active Rheumatoid Arthritis
Seropositive RAThe study is Phase II randomized, double-blind, placebo-controlled clinical trial to evaluate efficacy and safety, pharmacokinetics and pharmacodynamics of 2 dosing regimens (qw and q2w, s/c) of monoclonal antibody to IL6R (BCD-089) in patients with active rheumatoid arthritis and inadequate response to methotrexate.
Abatacept to Silence Anti-citrullinated Protein Antibody-expressing B Cells in Rheumatoid Arthritis...
Rheumatoid ArthritisRheumatic DiseasesTo investigate the effect of CTLA4-Ig (abatacept) on phenotype, transcriptional profile, B cell receptor usage and functional parameters of circulating B cells expressing anticitrullinated protein antibodies (ACPA) in patients with early, methotrexate-naïve, ACPA positive rheumatoid arthritis.
Phase IIb Study of Evobrutinib in Subjects With Rheumatoid Arthritis
Rheumatoid ArthritisThe purpose of this study was to determine the efficacy, dose response, and safety of M52951 in participants with Rheumatoid Arthritis (RA), and to consider a dose to took forward into Phase III development.
Mechanical Traction Force and Knee Joint Space
Knee Arthritisthe purposes of this crossover study are to Purpose To determine the most effective traction force for knee joint that can be used in the treatment of patients with KOA. To determine the influence of knee joint traction on ROM ok knee joint flexion and extension To determine the influence of knee joint traction on the flexibility of hamstring muscles
Randomized Controlled Trial of Total Hip Arthroplasty
Hip ArthritisTotal Hip Arthroplasty (THA)The purpose of this study is to compare the effect of total hip arthroplasty and conservative treatment to hip pain, to activities of daily life and to the quality of life in patients with hip osteoarthritis.
A Study to Investigate Efficacy, Tolerability and Safety of ABY-035 in Patients With Active Psoriatic...
Psoriatic ArthritisThis is a Phase II, prospective, multicenter, randomized, double-blind, placebo-controlled, dose finding trial in parallel-groups with primary endpoint at Week 16 (visit V9) to investigate the efficacy, tolerability, safety, pharmacokinetics and immunogenicity of ABY-035 in adult patients with PsA.
Study of Efficacy and Safety of Secukinumab in Chinese Subjects With Active PsA Compared to Placebo....
Psoriatic ArthritisThe purpose of this study was to assess the efficacy and safety of secukinumab in Chinese participants with active PsA compared to placebo
Role of Vitamin D3 Supplementation With Conventional Synthetic Disease Modifying Antirheumatic Drugs(csDMARD)...
Rheumatoid ArthritisSeveral studies suggested low serum level of vitamin D have been associated with rheumatoid arthritis. So, the present study was designed to investigate the effect of vitamin D supplementation along with CsDMARD in patients with rheumatoid arthritis.
A Proof-of-concept Study of the Efficacy and Safety of Nipocalimab in Participants With Active Rheumatoid...
ArthritisRheumatoidThe purpose of this study is to evaluate the efficacy and safety of nipocalimab versus placebo in participants with moderate to severe active rheumatoid arthritis (RA).
Effectiveness of Client-centered Intervention in After Total Knee Arthroplasty
Arthritis KneeThe current study was conducted to comparison of the Client-centered (CC) intervention with face-to-face (FF) and TR methods after Total Knee Arthroplasty (TKA). The pilot study was planned to examine the impact of the CC intervention on quality of life, perceived occupational performance and satisfaction. The current study was designed according to the CONSORT statement, which provides a standardized method for randomized controlled trial (RCT) design. Approval for the study was granted by the Local Ethics Committee. Written informed consent was obtained from all participants prior to the study.