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Active clinical trials for "Precancerous Conditions"

Results 121-130 of 244

Prostate Cancer Prevention Study for Men With High Grade PIN (Prostatic Intraepithelial Neoplasia)...

Preneoplastic ConditionsProstatic Intraepithelial Neoplasia

The purpose of this study is to determine if toremifene citrate is effective and safe in the prevention of prostate cancer in men who have been diagnosed with high grade prostatic intraepithelial neoplasia (PIN).

Completed29 enrollment criteria

S9917, Selenium in Preventing Cancer in Patients With Neoplasia of the Prostate

Precancerous/Nonmalignant ConditionProstate Cancer

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. The use of selenium may be an effective way to prevent prostate cancer in patients who have neoplasia of the prostate. PURPOSE: Randomized phase III trial to study the effectiveness of selenium in preventing prostate cancer in patients who have neoplasia of the prostate.

Completed37 enrollment criteria

Imiquimod in Preventing Cervical Cancer in Women With Cervical Neoplasia

Cervical CancerPrecancerous Condition

RATIONALE: Chemoprevention therapy is the use of certain substances to try to prevent the development of cancer. Applying topical imiquimod before abnormal cervical cells are removed may be effective in preventing cervical cancer. PURPOSE: Randomized phase II trial to study the effectiveness of applying topical imiquimod before abnormal cervical cells are removed in preventing cervical cancer in patients who have recurrent or persistent cervical neoplasia.

Completed21 enrollment criteria

Fenretinide in Treating Patients With Cervical Neoplasia

Cervical CancerPrecancerous Condition

RATIONALE: Chemoprevention uses drugs to try and prevent development of cancer. Fenretinide may be effective in treating cervical neoplasia and preventing cervical cancer. PURPOSE: Randomized double-blinded phase III trial to compare the effectiveness of fenretinide to placebo in treating patients with cervical neoplasia.

Completed3 enrollment criteria

Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With...

Anal CancerNeoplasm of Uncertain Malignant Potential2 more

RATIONALE: Infrared coagulator ablation may be effective in preventing the development of anal cancer in patients with anal neoplasia PURPOSE: This randomized phase III trial is studying infrared coagulator ablation to see how well it works compared to observation in preventing anal cancer in HIV-positive patients with anal neoplasia.

Completed35 enrollment criteria

Aspirin in Preventing Colorectal Cancer in Patients at Increased Risk of Colorectal Cancer

Colon CancerPrecancerous Condition1 more

This randomized phase II trial is studying how well aspirin works in preventing colorectal cancer in patients at increased risk of colorectal cancer. Chemoprevention is the use of certain drugs to keep cancer from forming. The use of aspirin may prevent colorectal cancer.

Completed36 enrollment criteria

Digital Colposcopy in Finding Cervical Intraepithelial Neoplasia

Cervical CancerPrecancerous Condition

RATIONALE: Diagnostic procedures, such as digital colposcopy, may help doctors find and diagnose cervical intraepithelial neoplasia. PURPOSE: This clinical trial is studying digital colposcopy to see how well it works in finding cervical intraepithelial neoplasia.

Completed12 enrollment criteria

Celecoxib in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia

Head and Neck CancerPrecancerous Condition

RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of celecoxib may prevent or treat head and neck cancer. PURPOSE: This randomized phase II trial is studying celecoxib to see how well it works compared to placebo in preventing head and neck cancer in patients with oral leukoplakia.

Completed56 enrollment criteria

Inositol in Preventing Lung Cancer in Patients With Bronchial Epithelial Dysplasia Who Are Current...

Lung CancerPrecancerous Condition

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Inositol may be effective in preventing the development of lung cancer in patients with bronchial epithelial dysplasia. PURPOSE: This phase I trial is studying the side effects and best dose of inositol in preventing lung cancer in current or former smokers with bronchial epithelial dysplasia.

Completed53 enrollment criteria

Chemoprevention of Oral Premalignant Lesions

Precancerous Conditions

Reduction in size and number of oral premalignant lesions

Completed2 enrollment criteria
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