Safety & Effectiveness on Vascular Structure and Function of ACZ885 in Atherosclerosis and Either...
Diabetes MellitusType 22 moreThis study will evaluate the effect of ACZ885 on vascular function in patients with documented atherosclerotic disease and T2DM or IGT.
Physical Exercise Versus Rosiglitazone in CAD and Prediabetes
Impaired Glucose ToleranceThe aim of this study is to prospectively assess the relative benefits of either treatment with rosiglitazone or physical exercise on endothelial function in patients with impaired fasting glucose or impaired glucose tolerance and coronary artery disease (CAD).
Treating the Endothelium to Restore Insulin Sensitivity
ObesityInsulin Resistance2 moreA study of 12 weeks' treatment with losartan or placebo, to test the hypothesis that RAS inhibition will improve insulin' vascular actions and therefore improve insulin sensitivity in skeletal muscle.
Effective Treatment of Sleep Apnea in Prediabetes to Reduce Cardiometabolic Risk
DiabetesSleep ApneaAlthough obstructive sleep apnea (OSA) is associated with impaired glucose tolerance and diabetes, it remains unclear whether OSA treatment with continuous positive airway pressure (CPAP) has metabolic benefits. The objective of this study is to determine the effect of 8-hour nightly CPAP treatment on glucose metabolism in individuals with prediabetes and OSA.
A Study to Evaluate the Effects of Vildagliptin on the Insulin Response to Glucose in Subjects With...
Pre-diabetesThis is an exploratory study to assess whether vildagliptin, an unapproved drug, can increase insulin secretion in subjects with pre-diabetes who have a defect in the insulin response and elevated levels of fasting glucose.
Chromium Picolinate for the Treatment of Metabolic Syndrome
Metabolic Syndrome XPrediabetic State3 moreThe purpose of this study is to determine whether chromium supplements can reduce symptoms of metabolic syndrome, a collection of symptoms that increase one's risk for developing heart disease, stroke, and diabetes.
Efficacy and Safety of Vildagliptin in Subjects With Impaired Glucose Tolerance
Prediabetic StateThe purpose of this study is to assess the safety and effectiveness of vildagliptin, an unapproved drug, compared to placebo in lowering post-meal blood glucose levels in people with pre-diabetes who have high blood sugar levels after meals.
Emotional Awareness and Expression Therapy for Prediabetes
PreDiabetesThis feasibility study seeks to develop and pilot test Emotional Awareness and Expression Therapy as a possible treatment for people with prediabetes.
Stanford Kids CAMP Study
Pre-diabetesObesity1 moreThe Stanford Kids CAMP study aims to evaluate the feasibility of enrolling minority participants in school age children (5-13 years old) in a community summer camp setting along with the efficiency by which each participant's biologic specimens are collected. Using remote monitoring technologies and through partnering with community-based organizations, the investigators hypothesize that an increase in underrepresented minority participation in a clinical trial that is greater than the national average is possible.
Assessing the Effects of HbA1c Reduction on Alleviating Nonspecific Back Pain
Back Pain Lower Back ChronicBack Pain4 morePrediabetes, characterized by elevated HbA1c levels, is a common precursor to type 2 diabetes mellitus. Recent studies have suggested a potential link between prediabetes and nonspecific back pain. This randomized controlled trial aimed to assess whether reducing HbA1c levels through lifestyle interventions and, along with the correction of vitamin D and magnesium, can alleviate nonspecific back pain in prediabetic patients.