mtDNA as Novel Biomarker for Intra-amniotic Infection
Preterm Premature Rupture of MembraneFinding a predictive biomarker for IAI could improve the clinical outcome for the mother and the neonate. The aim of this study is to quantify the copy number of circulating cell-free mitochondrial DNA in maternal serum and the placenta compared to controls.the investigators hypothesise that circulating cell-free mitochondrial DNA levels could help predict the likelihood of early inflammation in IAI. In addition, mitochondrial DNA could be a promotor triggering the pathogenesis of systemic inflammation.
Hospital Admission Versus Home Management in Women With Premature Rupture of Membranes :RCT
Management of Women With PROM at TermAccording to high tendency for admission of cases of premature rupture of membranes (PROM) for fear of maternal & fetal complications, we compare here between cases managed at hospital with other managed at home for if there any difference between in maternal and neonatal outcome.
Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management
Preterm Premature Rupture of MembranesThis study is to compare the maternal and neonatal outcomes in the patients with PPROM who are managed at home versus those managed at hospital, half the patients will be managed at home and the other half will be managed inpatient.
The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes...
Preterm Premature Rupture of MembranesTo study the association between maternal serum vitamin C concentration in women with preterm premature rupture of membranes (PPROM) and women without PPROM.
PROMComplete for Determination of Rupture of Fetal Membranes
Fetal MembranesPremature RupturePremature rupture of membranes refers to the rupture of the fetal membranes prior to the onset of labor. Premature rupture of membranes is associated with a number of neonatal and maternal complications including an increased incidence of perinatal mortality and intra-amniotic infection. There is a need for improved diagnostic testing because of limitations of the current methods. PRO-MComplete is an immunochromatographic test that detects insulin growth factor binding protein 1 and alpha-fetoprotein in vaginal fluid as an indicator of membrane rupture.
Myometrial Thickness as a Predictor for the Latency Interval in PPROM
Fetal MembranesPremature Rupture100 women divided into 3 groups: Group I: included 50 women with preterm premature rupture of membranes (PPROM, n=50) with gestational age from 24 to 34 weeks. Group II: included 25 term non-labor control (T-CTR, n=25) with gestational age from 37 to 41 weeks. Group III: included 25 preterm non-labor control (P-CTR, n=25) with gestational age from 24 to 34 weeks.The myometrial thickness at 4 different sites9: a) The lower uterine segment (LUS): 2cm above the reflection of the full urinary bladder (b)The anterior wall: 1cm above the maternal umbilicus. (c)Fundus: by placing the scan probe perpendicularly above the uterine fundus so that the entire curvature of the uterus was visualized. (d)The posterior wall: through using the maternal abdominal aortic pulsation as an anatomic marker. At least 3 measurements were obtained at each site and averaged. The latency interval is determined in each of the 3 groups.
Prediction of the Onset of Term and Preterm Labour
Preterm PregnancyPreterm Birth3 moreThis study will collect samples from pregnant women in order to identify biomarkers that relate to onset of spontaneous preterm labour.
Predictive Score for Neonatal Mortality for Women With Premature Rupture of Membranes Between 22...
Perinatal MortalityPremature Rupture of Fetal MembranesPretern premature rupture of the membranes (PPROM) remains the leading cause of preterm deliveries and neonatal mortality and morbidity. PPROM is defined as rupture of the fetal membranes prior to 37 weeks' gestation. PPROM complicates 2-4% of all pregnancies and accounts for approximately 30 % of preterm births. The etiology of PPROM remains elusive. PPROM is one of the main causes of prematurity and its complications, such as newborn respiratory distress syndrome, neonatal sepsis, necrotizing enterocolitis, intraventricular hemorrhage, perventricular leucomalacia, varying degrees of lung hypoplasia and bronchopulmonary dysplasia. All these factors contribute greatly to an increase in neonatal morbidity and mortality Management of PPROM followed actual guidelines. Conservative management to prolong a pregnancy is a classical approach to treat PPROM before 34 weeks' gestation in association with antibiotic therapy and corticosteroids. Maternal and neonatal data were collected from maternal and newborns medical records.
Rapid Immunoassay Tests for the Detection of Ruptured Membranes
Premature Rupture of MembranesThe aim of the study is to demonstrate substantial equivalence of IGFBP-1/AFP tests with the "predicate device" Amnisure® in detecting pre labor rupture of membranes. 4 test kits are compared against a common referent standard (gold standard), which is clinical assessment.
Pancreatic Stone Protein (PSP) in Pregnant Women
PregnancyHELLP Syndrome2 moreThis prospective, single centred cohort study evaluates the physiological course of the potentially novel biomarker PSP in pregnant women as well as its predictive role in the development of inflammatory complications during pregnancy.