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Active clinical trials for "Fetal Membranes, Premature Rupture"

Results 111-120 of 122

mtDNA as Novel Biomarker for Intra-amniotic Infection

Preterm Premature Rupture of Membrane

Finding a predictive biomarker for IAI could improve the clinical outcome for the mother and the neonate. The aim of this study is to quantify the copy number of circulating cell-free mitochondrial DNA in maternal serum and the placenta compared to controls.the investigators hypothesise that circulating cell-free mitochondrial DNA levels could help predict the likelihood of early inflammation in IAI. In addition, mitochondrial DNA could be a promotor triggering the pathogenesis of systemic inflammation.

Unknown status7 enrollment criteria

Hospital Admission Versus Home Management in Women With Premature Rupture of Membranes :RCT

Management of Women With PROM at Term

According to high tendency for admission of cases of premature rupture of membranes (PROM) for fear of maternal & fetal complications, we compare here between cases managed at hospital with other managed at home for if there any difference between in maternal and neonatal outcome.

Unknown status4 enrollment criteria

Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management

Preterm Premature Rupture of Membranes

This study is to compare the maternal and neonatal outcomes in the patients with PPROM who are managed at home versus those managed at hospital, half the patients will be managed at home and the other half will be managed inpatient.

Unknown status12 enrollment criteria

The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes...

Preterm Premature Rupture of Membranes

To study the association between maternal serum vitamin C concentration in women with preterm premature rupture of membranes (PPROM) and women without PPROM.

Unknown status9 enrollment criteria

PROMComplete for Determination of Rupture of Fetal Membranes

Fetal MembranesPremature Rupture

Premature rupture of membranes refers to the rupture of the fetal membranes prior to the onset of labor. Premature rupture of membranes is associated with a number of neonatal and maternal complications including an increased incidence of perinatal mortality and intra-amniotic infection. There is a need for improved diagnostic testing because of limitations of the current methods. PRO-MComplete is an immunochromatographic test that detects insulin growth factor binding protein 1 and alpha-fetoprotein in vaginal fluid as an indicator of membrane rupture.

Unknown status11 enrollment criteria

Myometrial Thickness as a Predictor for the Latency Interval in PPROM

Fetal MembranesPremature Rupture

100 women divided into 3 groups: Group I: included 50 women with preterm premature rupture of membranes (PPROM, n=50) with gestational age from 24 to 34 weeks. Group II: included 25 term non-labor control (T-CTR, n=25) with gestational age from 37 to 41 weeks. Group III: included 25 preterm non-labor control (P-CTR, n=25) with gestational age from 24 to 34 weeks.The myometrial thickness at 4 different sites9: a) The lower uterine segment (LUS): 2cm above the reflection of the full urinary bladder (b)The anterior wall: 1cm above the maternal umbilicus. (c)Fundus: by placing the scan probe perpendicularly above the uterine fundus so that the entire curvature of the uterus was visualized. (d)The posterior wall: through using the maternal abdominal aortic pulsation as an anatomic marker. At least 3 measurements were obtained at each site and averaged. The latency interval is determined in each of the 3 groups.

Unknown status10 enrollment criteria

Prediction of the Onset of Term and Preterm Labour

Preterm PregnancyPreterm Birth3 more

This study will collect samples from pregnant women in order to identify biomarkers that relate to onset of spontaneous preterm labour.

Unknown status26 enrollment criteria

Predictive Score for Neonatal Mortality for Women With Premature Rupture of Membranes Between 22...

Perinatal MortalityPremature Rupture of Fetal Membranes

Pretern premature rupture of the membranes (PPROM) remains the leading cause of preterm deliveries and neonatal mortality and morbidity. PPROM is defined as rupture of the fetal membranes prior to 37 weeks' gestation. PPROM complicates 2-4% of all pregnancies and accounts for approximately 30 % of preterm births. The etiology of PPROM remains elusive. PPROM is one of the main causes of prematurity and its complications, such as newborn respiratory distress syndrome, neonatal sepsis, necrotizing enterocolitis, intraventricular hemorrhage, perventricular leucomalacia, varying degrees of lung hypoplasia and bronchopulmonary dysplasia. All these factors contribute greatly to an increase in neonatal morbidity and mortality Management of PPROM followed actual guidelines. Conservative management to prolong a pregnancy is a classical approach to treat PPROM before 34 weeks' gestation in association with antibiotic therapy and corticosteroids. Maternal and neonatal data were collected from maternal and newborns medical records.

Unknown status5 enrollment criteria

Rapid Immunoassay Tests for the Detection of Ruptured Membranes

Premature Rupture of Membranes

The aim of the study is to demonstrate substantial equivalence of IGFBP-1/AFP tests with the "predicate device" Amnisure® in detecting pre labor rupture of membranes. 4 test kits are compared against a common referent standard (gold standard), which is clinical assessment.

Unknown status3 enrollment criteria

Pancreatic Stone Protein (PSP) in Pregnant Women

PregnancyHELLP Syndrome2 more

This prospective, single centred cohort study evaluates the physiological course of the potentially novel biomarker PSP in pregnant women as well as its predictive role in the development of inflammatory complications during pregnancy.

Unknown status5 enrollment criteria
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