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Active clinical trials for "Precancerous Conditions"

Results 111-120 of 244

Vaccine Therapy in Preventing Cervical Cancer in Patients With Cervical Intraepithelial Neoplasia...

Cervical CancerPrecancerous Condition

RATIONALE: Vaccines made from protein and DNA may help the body build an effective immune response to kill abnormal cells in the cervix. The use of vaccine therapy may prevent cervical cancer. PURPOSE: This phase I/II trial is studying the side effects and best dose of vaccine therapy and to see how well it works in preventing cervical cancer in patients with cervical intraepithelial neoplasia and human papillomavirus.

Completed8 enrollment criteria

Vitamin E, Selenium, and Soy Protein in Preventing Cancer in Patients With High-Grade Prostate Neoplasia...

Precancerous/Nonmalignant ConditionProstate Cancer

RATIONALE: Chemoprevention therapy is the use of certain substances to try to prevent the development or recurrence of cancer. Vitamin E, selenium, and soy protein may be effective in preventing the development of prostate cancer. PURPOSE: Randomized phase III trial to study the effectiveness of combining vitamin E, selenium, and soy protein in preventing prostate cancer in patients who have high-grade prostate neoplasia.

Completed47 enrollment criteria

Vaccine Therapy in Preventing Human Papillomavirus Infection in Young HIV-Positive Male Patients...

Anal CancerNonneoplastic Condition2 more

RATIONALE: Vaccines made from a gene-modified virus may help the body build an effective immune response to prevent viral infection. PURPOSE: This phase II trial is studying how well vaccine therapy works in preventing human papillomavirus (HPV) infection in young HIV-positive male patients who have sex with males.

Completed38 enrollment criteria

Combined Digital Colposcopy Analysis to Improve Cervical Precancer and Cancer Detection

Cervical CancerPrecancerous Condition

Precancerous lesions of the cervix occur frequently and are treatable. This justifies a population-based screening program. Following an abnormal Pap smear, patients are referred for a colposcopic exam to confirm the presence/stage of disease and select appropriate treatments. Unfortunately, these approaches do not detect all lesions or can sometimes give 'false positive' results (resulting in overtreatment). We are testing a device called a 'multispectral digital colposcope' to determine whether it is more effective at detecting precancerous cervical lesions than existing tools. Success in our study will make diagnoses more accurate and reduce the costs associated with unnecessary treatments.

Completed9 enrollment criteria

Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions...

Lip and Oral Cavity Squamous Cell CarcinomaOral Cavity Verrucous Carcinoma1 more

This randomized phase II trial studies how well vandetanib works in preventing head and neck cancer in patients with precancerous head and neck lesions. Chemoprevention is the use of certain drugs to keep cancer from forming. The use of vandetanib may keep cancer from forming in patients with premalignant lesions

Completed33 enrollment criteria

Detection of Early Gastric Cancers Using Confocal Laser Endomicroscopy

Stomach NeoplasmsPrecancerous Conditions

The purpose of this study is to determine whether endomicroscopy can improve the detection of Early Gastric Cancers (EGC).

Completed16 enrollment criteria

Optical Coherence Tomography in Tissue Samples From Women Undergoing Mastectomy for the Treatment...

Precancerous Condition

RATIONALE: New diagnostic procedures, such as optical coherence tomography, may be effective in finding tumor cells. PURPOSE: This clinical trial is studying optical coherence tomography in tissue samples from women undergoing mastectomy for the treatment or prevention of breast ductal intraepithelial neoplasia.

Completed6 enrollment criteria

Folic Acid Clinical Trial for the Prevention of Cervical Cancer

Cervical CancerPrecancerous Condition

RATIONALE: Supplements, such as folic acid, may stop or delay the development of cervical cancer in women infected with human papillomavirus. PURPOSE: This phase II trial is studying how well folic acid supplements work in preventing cancer in women infected with human papillomavirus.

Completed20 enrollment criteria

Lovastatin in Treating Patients At High Risk of Melanoma

Precancerous ConditionStage 0 Melanoma2 more

The use of lovastatin may slow disease progression in patients at high risk of melanoma. It is not yet known whether lovastatin is more effective than a placebo in treating patients at high risk of melanoma. This randomized phase II trial studies how well giving lovastatin or placebo works in treating patients at high risk of melanoma.

Completed32 enrollment criteria

Prostate Cancer Prevention Study for Men With High Grade PIN (Prostatic Intraepithelial Neoplasia)...

Preneoplastic ConditionsProstatic Intraepithelial Neoplasia

The purpose of this study is to determine if toremifene citrate is effective and safe in the prevention of prostate cancer in men who have been diagnosed with high grade prostatic intraepithelial neoplasia (PIN).

Completed29 enrollment criteria
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