search

Active clinical trials for "Lymphohistiocytosis, Hemophagocytic"

Results 61-70 of 77

Ruxolitinib as a Salvage Therapy for Hemophagocytic Lymphohistiocytosis

Hemophagocytic Lymphohistiocytosis

This study aimed to investigate the efficacy and safety of different doses of ruxolitinib as a salvage therapy for refractory/relapsed hemophagocytic lymphohistiocytosis(HLH).

Unknown status17 enrollment criteria

Combination Chemotherapy Followed By Donor Stem Cell Transplant in Treating Patients With Hemophagocytic...

Nonneoplastic Condition

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of hemophagocytic lymphohistiocytosis cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more hemophagocytic lymphohistiocytosis cells. A donor stem cell transplant may be able to replace blood-forming cells that were destroyed by chemotherapy. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Cyclosporine and methotrexate may stop this from happening. PURPOSE: This phase III trial is studying how well combination chemotherapy followed by a donor stem cell transplant works in treating patients with hemophagocytic lymphohistiocytosis.

Unknown status33 enrollment criteria

Etoposide in the First-line Treatment of Adult EBV-HLH

Hemophagocytic Lymphohistiocytosis

his study aimed to investigate the efficacy of etoposide as the first line therapy for adult Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.

Unknown status12 enrollment criteria

Chidamide Combines With VP-16 and Methylprednisolone in the Treatment of HLH

ChidamideHemophagocytic Lymphohistiocytosis

Chidamide combines with VP-16 and methylprednisolone in HLH

Unknown status2 enrollment criteria

L-DEP as an Initial Treatment for EBV-HLH

Hemophagocytic Lymphohistiocytosis

This study aimed to investigate the efficacy and safety of Pegaspargase together with liposomal doxorubicin, etoposide and high dose methylprednisolone (L-DEP) as an initial treatment for Epstein Barr virus-induced hemophagocytic lymphohistiocytosis.

Unknown status12 enrollment criteria

Trial of DA-EPOCH Regimen for NHL With HLH

NHL With Hemophagocytic Lymphohistiocytosis

The major purpose of this clinical study is to assess clinical outcome of dose-adjusted EPOCH regimen for patients with non-Hodgkin's lymphoma(NHL)-associated hemophagocytic lymphohistiocytosis

Unknown status9 enrollment criteria

A Study of TQ05105 Tablets in Subjects With Hemophagocytic Lymphohistiocytosis(HLH)

Hemophagocytic Lymphohistiocytosis

This is a phase I study of TQ05105 tablets in subjects with Hemophagocytic Lymphohistiocytosis.TQ05105 is a JAK2 inhibitors and can be used to treat JAK2 target-related diseases. The activation of the JAK/STAT pathway is related to abnormal proliferation, obstruction of apoptosis, and differentiation disorder of leukemia cells which is caused by genetic abnormalities and viral infection.

Unknown status6 enrollment criteria

Ruxolitinib Combined With Dexamethasone for HLH

Hemophagocytic Lymphohistiocytosis

A protocol named as "HLH-DR" for patients with refractory and secondary hemophagocytic lymphohistiocytosismay.

Unknown status2 enrollment criteria

Study to Evaluate Interferon Gamma (IFNγ) and Other Inflammatory Mediators in Patients With Malignancy-Associated...

Hemophagocytic Lymphohistiocytosis

This observational study is designed to provide a better understanding of the potential use of IFNγ and IFNγ-inducible chemokines as markers of HLH disease activity and prognosis, and of the potential of IFNγ as a therapeutic target in M-HLH.

Completed4 enrollment criteria

Evaluation of IFNγ and Inflammatory Mediators in Patients With Hemophagocytic Lymphohistiocytosis...

Hemophagocytic Lymphohistiocytoses

This observational study is designed to provide a better understanding of the potential use of interferon gamma (IFNγ) and IFNγ-inducible chemokines as markers of HLH disease activity in adults, and the potential of IFNγ to represent a therapeutic target.

Completed5 enrollment criteria
1...678

Need Help? Contact our team!


We'll reach out to this number within 24 hrs