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Active clinical trials for "Primary Ovarian Insufficiency"

Results 41-50 of 133

Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy

Primary Ovarian InsufficiencyPremature Ovarian Failure

This is a multi-centers of long term safety and efficacy follow up study for patients with premature ovarian failure (the women aged younger than 40 years, who present with amenorrhoea, hypergonadotropic hypogonadism, and infertility) who have been treated with ex vivo gene therapy drug product in Institute of Bio-Stem Cell Rehabilitation UAB - sponsored clinical studies. After completing the parent clinical study (approximately 6 month), eligible subject will be followed for additional 2 years for total of 2 years and 6 month post drug product infusion. No investigation drug product will be administered in the study

Active8 enrollment criteria

Study of Oral Dehydroepiandrosterone(DHEA) to Treat Previously Unexplained Infertility

Primary Ovarian InsufficiencyUnexplained Infertility

The experimental focus of this project is on the interaction of DHEA treatment on pregnancy in women with otherwise unexplained infertility and evidence of premature ovarian aging (POA).

Terminated15 enrollment criteria

Dehydroepiandrosterone (DHEA) Treatment and Premature Ovarian Failure (POF)

Premature Ovarian Failure

The experimental focus of this project is on the interaction of DHEA treatment on pregnancy in women with open tubes, fertile male partners and evidence of premature ovarian failure.

Terminated14 enrollment criteria

In Vitro Follicle Activation

Primary Ovarian InsufficiencyInfertility

The purpose of this study is to evaluate the effectiveness of an experimental treatment, known as in vitro activation (IVA) of dormant ovarian follicles, for infertility in women diagnosed with primary ovarian insufficiency (POI).

Terminated3 enrollment criteria

Autologous Bone Marrow Transplantation for Premature Ovarian Insufficiency

Premature Ovarian Failure

Currently, There is no treatment for Premature ovarian insufficiency (POI). Very small embryonic-like stem cells (VSELs) are found in the ovary. VSELs are able to regenerate the affected ovary. Stimulation was achieved by injection of mesenchymal stem cells that is supposed to secrete trophic factors. Numerous studies in mice have proved the efficacy of bone marrow transplantation (BMT) in resuming the ovarian function after chemotherapy-induced ovarian insufficiency. Allogeneic BMT raised the moral conflict about the origin of the newly developed oocytes. Several small studies examined the use of autologous BMT both in animal and in human. The results of these studies were promising. Intravenous injection is simpler and less invasive than ovarian injection as the later involves the use of laparoscopy. However, intravenous injection has not tested until now.

Terminated5 enrollment criteria

Rejuvenation of Premature Ovarian Failure With Stem Cells

Primary Ovarian InsufficiencyLow Ovarian Reserve1 more

The ROSE-1 study is designed to determine the efficacy of bone marrow derived stem cell therapy on ovarian function recovery in subjects with idiopathic and other types of premature or primary ovarian failure (POF or POI) and low ovarian reserves.

Completed28 enrollment criteria

Chinese Medicine(Hu Yang Yang Kun Formula) for Primary Ovarian Insufficiency

Primary Ovarian Insufficiency

The purpose of this research is providing valuable traditional chinese medicine theory and formula in treating Primary Ovarian insufficiency.

Completed17 enrollment criteria

Ovarian Rejuvenation for Premature Ovarian Insufficiency and Poor Ovarian Response

Ovarian FailureInfertility1 more

The objective of this study is to perform a prospective randomized controlled trial seeking to characterize the effects of intra-ovarian injection of platelet rich plasma (PRP) on biomarkers of ovarian reserve as well as IVF outcomes in women with primary ovarian insufficiency (POI) and poor ovarian response (POR) who decline the use of an egg donor to establish a pregnancy.

Completed25 enrollment criteria

Primary Ovarian Insufficiency: Phenotype and Optimal Treatment

Primary Ovarian Insufficiency

This pilot study will observe the progression of newly diagnosed POI patients physical and psychology outcomes after initiating standard of care HRT treatment in comparison to healthy female control participants' physical and psychology health over 24 months.

Completed24 enrollment criteria

Comparison of Transdermal and Oral Estrogens in Adolescent Girls With Ovarian Failure

Ovarian FailurePremature

To directly compare the safety (by laboratory evaluation) and efficacy (feminization and growth) of three commonly used estrogen preparations in adolescent patients with ovarian failure, either due to congenital causes (Turner syndrome) or medical therapies. We hypothesize that transdermal estrogen will have equivalent efficacy and a more favorable safety profile in comparison with conventional oral estrogen replacement.

Completed7 enrollment criteria
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