Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders
PSPCBD10 moreThe investigators aim to learn more about symptoms suggestive of a neurodegenerative process.
Impact of Walking Practice on Persons With PD
Parkinson's DiseaseThe purpose of this study is to investigate the impact of a specifically designed leg brace on walking endurance in individuals with Parkinson's disease.
Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
Idiopathic Parkinson's DiseaseDrug Induced DyskinesiaThe study will involve an eighteen-week, double-blind, placebo-controlled parallel designed comparison between add-on topiramate and add-on placebo to stable treatment with amatadine in the treatment of Parkinson's disease (PD) patients who continue to have dyskinesia on amantadine.
NET-PD LS-1 Creatine in Parkinson's Disease
Parkinson's DiseaseThe purpose of this trial is to determine if the nutritional supplement creatine slows the progression of Parkinson's disease over time.
Binding of Foliglurax to Regions in the Brain in Healthy Participants and in Patients With Parkinson's...
HealthyParkinson DiseaseA study to learn how foliglurax binds in regions of the brain
Advancing Pre-operative Targeting for Deep Brain Stimulation in the Globus Pallidus Internus
Parkinson DiseaseIn the proposed pilot project, MRI data will be prospectively collected to show the feasibility of the segmentation algorithm and the potential relation to final lead positioning. Patients will be selected from those undergoing GPi DBS placement. This pilot data will serve as a basis for pursuing funding for a larger trial evaluating the prospective ability of the 3T targeting study to improve outcomes and decrease complications in GPi DBS placement. Improved outcomes and patient experience would be expected to further contribute to our facility as a center of excellence for treatment of movement disorders.
North American Prodromal Synucleinopathy Consortium
REM Sleep Behavior DisorderParkinson Disease4 moreThis study will enroll participants with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD), for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity
Alzheimer DiseaseEarly Onset1 moreThe aim of the NODAL clinical trial is to demonstrate the feasibility of new, low-cost, non-invasive biomarkers of neurodegenerative pathologies as early Alzheimer and Parkinson, based on the estimation of the multimodal connectome.
Assessment of Perampanel (E2007) on Synaptic Dopamine in Mild-moderate PD Patients: A Pilot Study...
Parkinson's DiseaseThis is a two-arm, double-blind, placebo-controlled study.
A Study of E2007 In Patients With Parkinson's Disease
Parkinson's DiseasePhase IIb open-label extension study for patients with Parkinson's Disease. All patients will receive active study drug. The study will involve outpatient visits only. Patients who completed Study E2007-A001-214 (Cohorts I and II) and who meet inclusion/exclusion criteria will be enrolled and enter the 12-week Titration Phase (from "Dispense Study Drug" at Week 0 [Visit 2] through Week 12 [Visit 7]) followed by the Maintenance Phase (from Week 12 [Visit 7] to end of study).