Active clinical trials for "Propofol Infusion Syndrome"

Background: Propofol based sedated anesthesia was widely used in percutaneous radiofrequency ablation and hypoxia is one of the most frequent adverse events during this procedure. No effective methods have been found to prevent hypoxia so far. The aim of this study was to evaluate whether the incidence of hypoxia was different under high-flow nasal cannula (HFNC) therapy, which can provide heated and humidified oxygen up to 60L/minute. Methods: In a randomized, prospective and double-blind study, 318 patients undergo percutaneous radiofrequency ablation based on propofol sedation were assigned into two groups: the nasal cannula group (O2 [6 L/minute] was supplied via an HFNC) and the HFNC group (O2 [40 L/minute] was supplied via an HFNC). The primary outcome is the incidence of hypoxia during surgery. Other adverse events were also recorded.

Propofol causes injection pain is still a common clinical unsolved problem. Mixing a small amount of lidocaine with propofol or injecting lidocaine in advance can reduce the pain caused by propofol injection. Using an air warmer to warm the arm can also reduce the pain caused by propofol injection. Investors suspect that treatment with a warming patch (covering the injection site) can also reduce the pain caused by propofol injection.

Propofol injection pain will be surfed by up to 70-80 percentage by the Patients who induced by propofol. Temperature of Operating room was set to a certain range in normal clinical practice, which is 22- 26 centigrade. Warm feeling will make skin vassal dilated and more blood will pass through to bring more heat out of our body. It had been reported that a bigger venous vessels will get less propofol injection pain. The investigators hypothesis that Patients who stayed in a warmer room temperature will surf less injection pain while compare to a normal setting room temperature.