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Active clinical trials for "Prostatic Neoplasms"

Results 3131-3140 of 5298

MR-Guided Laser Interstitial Thermal Therapy in Treating Patients With Prostate Cancer

Stage I Prostate CancerStage II Prostate Carcinoma

This phase II trial studies how well magnetic resonance (MR)-guided laser interstitial thermal therapy works in treating patients with prostate cancer. Laser therapy uses intense, narrow beams of light to cut and destroy tissue and may help treat prostate cancer

Completed24 enrollment criteria

[F-18] Fluorothymidine PET/CT Imaging for Pelvic Cancers

Uterine Cervical NeoplasmsEndometrial Neoplasms3 more

[F-18] Fluorothymidine PET imaging will be used to create a radiation therapy treatment plan to avoid active bone marrow in the pelvis. This will be done to evaluate if sparing bone marrow will help maintain blood counts. This would impact chemotherapy administration.

Completed15 enrollment criteria

Dovitinib(TKI258) in Patients With Castration-resistant Prostate Cancer

Hormone Refractory Prostate Cancer

The aim of this study is to evaluate efficacy and safety of Dovitinib(TKI258) in patients with castration resistant prostate cancer after failure of docetaxel-based chemotherapy. Further correlative study for metabolic response using PET image and change in serum fibroblast growth factor 23(FGF23) will be conducted.

Completed18 enrollment criteria

One Month Degarelix/Comparator Treatment for Prostate Cancer in Chinese Population

Prostate Cancer

One month degarelix/comparator treatment for prostate cancer in Chinese population

Completed8 enrollment criteria

Itraconazole in Treating Patients With Biochemically Relapsed Prostate Cancer

Prostate AdenocarcinomaRecurrent Prostate Carcinoma3 more

This phase II trial studies how well itraconazole works in treating patients with biochemically relapsed prostate cancer. Itraconazole may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Completed45 enrollment criteria

Abiraterone Acetate Plus LHRH Agonist and Abiraterone Acetate Plus LHRH Agonist and Enzalutamide...

Prostate Cancer

The goal of this clinical research study is to learn if adding the combination of abiraterone acetate and prednisone with or without enzalutamide to hormonal therapy can help to control prostate cancer when given before surgery. The safety of the drug combination will also be studied.

Completed50 enrollment criteria

Open Label Phase Two Trial of Radium Ra 223 Dichloride With Concurrent Administration of Abiraterone...

Prostate Cancer

This is an open label study designed to examine the effects on concurrent administration of Radium Ra 223 dichloride and Abiraterone Acetate plus Prednisone in subjects with symptomatic castrate resistant prostate cancer and with bone metastases, in both the pre- and post- chemotherapy setting. Both medications are approved by the US Food and Drug Administration for this indication.

Completed54 enrollment criteria

F-choline PET in Early Response Assessment for Castration Resistant Prostatic Cancer

Castration-resistant Prostate Cancer

Until today no current diagnostic tool exists to identify an early objective response when patients with castration-resistant prostate cancer were treated by abiraterone acetate or enzalutamide. According to the Prostate Cancer Working Group, the investigators have to wait 12 weeks before the first evaluation. To know soon that the treatment is effective will be decisive for the oncologist, even more in palliative situation where second effects can't be imposed to patients. In post-docetaxel, the F-choline PET-CT could be used to assess the response of this new therapy. Moreover, the investigators suppose that we can assess an early stage if there is an objective therapeutic response, at 6 weeks of treatment, in order to avoid unnecessarily and expansive treatment. The aim of this study is to assess if it is possible to determine early (6 weeks of treatment)if a F-choline PET-CT could predict the response to abiraterone acetate or enzalutamide in post-docetaxel.

Terminated18 enrollment criteria

Novel Window of Opportunity Trial to Evaluate the Impact of Statins to Oppose Prostate Cancer

Prostate Cancer

This research study provides a novel opportunity to examine the intra-prostatic tumour inhibitory effects of statins in men with prostate cancer undergoing surgery.

Completed29 enrollment criteria

A Study to Assess the Effect of Abiraterone Acetate in Male Participants With Mild or Moderate Hepatic...

Prostate Cancer

The purpose of this study is to evaluate the safety and pharmacokinetics (study of what the body does to a drug) of 1000 mg oral dose of abiraterone acetate and its major metabolite(s) with mild or moderate hepatic impairment and matched control Participants with normal hepatic function.

Completed23 enrollment criteria
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